Src inhibitor 1

Manufactured by Santa Cruz Biotechnology

SRC-inhibitor-1 is a laboratory reagent that inhibits the activity of the SRC protein, a tyrosine kinase involved in various cellular processes. This compound can be used in research applications to study the role of SRC signaling in biological systems.

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Lab products found in correlation

Universal tyrosine kinase assay kit, by Takara Bio (1 mentions) Methylglyoxal, by Merck Group (1 mentions)

Close spelling variants of this product

SRC-1

2 protocols using src inhibitor 1

Tyrosine Phosphatase and Kinase Assays

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Methylglyoxal was from Sigma-Aldrich. SHP-2-inhibitor, NSC 87877 was from Tocris Bioscience, SRC-inhibitor-1 was from Santa Cruz Biotechnology. Protein tyrosine phosphatse activity assay kit was from Promega. Universal Tyrosine kinase assay kit was from Takara. RT-qPCR primers, hRPLO, hSHP-1, hSHP-2, mSHP-1, mSHP-2 were obtained from Sigma Aldrich.

Dorenkamp M., Müller J.P., Shanmuganathan K.S., Schulten H., Müller N., Löffler I., Müller U.A., Wolf G., Böhmer F.D., Godfrey R, & Waltenberger J. (2018). Hyperglycaemia-induced methylglyoxal accumulation potentiates VEGF resistance of diabetic monocytes through the aberrant activation of tyrosine phosphatase SHP-2/SRC kinase signalling axis. Scientific Reports, 8, 14684.

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Osteoblast and Osteocyte Src Inhibition

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MC3T3 osteoblasts and MLO-Y4 osteocytes were treated with Src Inhibitor 1 (Santa Cruz Biotechnology, Santa Cruz, CA) (10 µM) for 1 hour before experiments were conducted. Control samples were treated with DMSO.

Hum J.M., Day R.N., Bidwell J.P., Wang Y, & Pavalko F.M. (2014). Mechanical Loading in Osteocytes Induces Formation of a Src/Pyk2/MBD2 Complex That Suppresses Anabolic Gene Expression. PLoS ONE, 9(5), e97942.

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