Paracetamol

Manufactured by Mallinckrodt

Sourced in United States

Paracetamol is a commonly used active pharmaceutical ingredient for the production of various pharmaceutical and healthcare products. It is a white, crystalline powder with a slightly bitter taste. Paracetamol is widely used as an analgesic (pain reliever) and antipyretic (fever reducer) in a variety of medical applications.

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Lab products found in correlation

2 protocols using paracetamol

Solubility and Physicochemical Profiling of Drugs

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Sodium taurocholate, cholesterol, sodium chloride (NaCl), sodium oleate, ammonium formate, formic acid, potassium hydroxide (KOH), hydrochloric acid (HCl), griseofulvin, furosemide, dipyridamole, and acyclovir were purchased from Merck Chemicals Ltd. Ibuprofen was obtained from BSAF chemical company, Paracetamol was from Mallinckrodt Pharmaceuticals and mefenamic acid from Sigma Aldrich. Phosphatidylcholine from soybean (PC S) was purchased from Lipoid company. See Table 1 for physicochemical properties and molecular structures. Chloroform was from Rathburn Chemical Company, FaSSIF media was purchased from Biorelevant.com, and sodium phosphate monobasic monohydrate (NaH₂PO₄·H₂O) was purchased from Fisher Scientific. All acetonitrile (ACN) and methanol (MeOH) solvents were HPLC gradient (VWR). All water is ultrapure Milli-Q water.Table 1

Physicochemical properties and molecular structures of drugs.

Compound	a/b/n	pKa	LogP
Ibuprofen	a	5.3	3.97

mefenamic acid	a	4.2	5.12

furosemide	a	3.9	2.03

dipyridamole	b	6.2	3.77

Paracetamol	n	–	0.46

griseofulvin	n	–	2.18

acyclovir	n	2.52/9.35	−1.56

Abuhassan Q., Khadra I., Pyper K., Augustijns P., Brouwers J, & Halbert G.W. (2022). Fasted intestinal solubility limits and distributions applied to the biopharmaceutics and developability classification systems. European Journal of Pharmaceutics and Biopharmaceutics, 170, 160-169.

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Polymer-based paracetamol formulation

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Pharmaceutical grade paracetamol was sourced from Mallinckrodt Inc. (Raleigh, USA). Hydroxypropyl methylcellulose grade Affinisol TM 15LV was kindly donated by Dow Inc. (The Dow Chemical Company, Michigan, USA). Crystalline 𝛾-polymorph indomethacin of purity ≥ 98.5% and polyvinylpyrrolidone grade PVP Kollidon ® 25 were purchased from Sigma-Aldrich (Dorset, UK). Skeletal structural formulae and repeat units of the chemicals used in the study are illustrated in Fig. S1 of the supplementary information.

Paladino E., Doerr F.J.S., Bordos E., Onyemelukwe I.I., Lamprou D.A., Florence A.J., Gilmore I.S, & Halbert G.W. (2022). High spatial resolution ToF-SIMS imaging and image analysis strategies to monitor and quantify early phase separation in amorphous solid dispersions. International journal of pharmaceutics, 628.

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