1 methylpiperazine

Manufactured by Merck Group

Sourced in United Kingdom

1-methylpiperazine is a chemical compound that serves as a key intermediate in the synthesis of various pharmaceutical and industrial products. It is a colorless, viscous liquid with a characteristic amine-like odor. The compound is widely used as a building block in the development of diverse chemical entities. Its core function is to provide a versatile platform for further chemical transformations and derivatization, enabling the creation of a wide range of end-use products.

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3 protocols using 1 methylpiperazine

Synthesis and Purification of Heterocyclic Compounds

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2-Aminobenzylamine,
phosphorus oxychloride, 1-methylpiperazine, and iron powder were purchased
from Sigma-Aldrich (St. Louis, MO), while isatin, 5-nitroisatin, and
2-pyridinecarboxaldehyde were purchased from Acros (Geel, Belgium).
All chemicals, as well as the synthesized precursors, were used without
further purification. 2-Amino-5-nitrobenzylamine hydrochloride was
synthesized according to a procedure published elsewhere.⁴⁶ The free amine was obtained by the dissolution
of the hydrochloride in a minimal amount of water, addition of 4 equiv
of aqueous ammonia, and collection of the formed precipitate by filtration.
Ethanol was dried over molecular sieves (3 Å), and tetrahydrofuran
(THF) was dried by using a standard procedure (Na/benzophenone).⁴⁷

Filak L.K., Kalinowski D.S., Bauer T.J., Richardson D.R, & Arion V.B. (2014). Effect of the Piperazine Unit and Metal-Binding Site Position on the Solubility and Anti-Proliferative Activity of Ruthenium(II)- and Osmium(II)- Arene Complexes of Isomeric Indolo[3,2-c]quinoline—Piperazine Hybrids. Inorganic Chemistry, 53(13), 6934-6943.

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Synthesis of Naphthalic Anhydride Derivatives

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4-Bromo-1,8-naphthalic anhydride, FA, ethanethiol, cysteamine hydrochloride, 2-mercapto ethanol, aldrithiol-2, 1-methylpiperazine, N,N-dimethylethylendiamine, 8-aminoquinoline, 2-hydroxyethyl disulfide, tris(2-carboxyethyl)phospine hydrochloride, potassium hydroxyde and triethylamine were purchased from Sigma-Aldrich (UK); ethanol, methanol, dichloromethane ethyl, acetate, acetone, acetonitrile and the low iron silica sand were purchased from Fluka (UK). Diethyl ether, n-hexane, dimethylformamide, tetrahydrofurane (HPLC grade) and the silica gel were purchased by VWR. Potassium carbonate was provided by Alfa Aeser (UK). Ultra-dry dimethyl sulfoxyde 99.7% and sodium hydroxide were obtained by Fisher scientific (UK). 2-Methoxyethanol from Honeywell Riedel-de Haen (UK). Chloroform-D and dimethyl sulfoxide-D6 by Cambridge Laboratories (UK). All the reagents were used without further purification.

Saito G., Velluto D, & Resmini M. (2018). Synthesis of 1,8-naphthalimide-based probes with fluorescent switch triggered by flufenamic acid. Royal Society Open Science, 5(6), 172137.

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Microfluidic Fluorescence Protein Fractionation

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Albumin–fluorescein isothiocyanate conjugate (FITC‐BSA), R‐Phycoerythrin (R‐PE), ethylenediamine (≥99.5 %), and 1‐Methylpiperazine (≥99.5 %) were purchased from Sigma‐Aldrich (Sigma‐Aldrich Chemie BV, Zwijndrecht, The Netherlands). 0.5 g/L of FITC‐BSA solution, 0.5 g/L of R‐PE solution, 1:100 diluted Source 15Q (∅ 15 μm particles based on rigid polystyrene/divinyl benzene polymer matrix, GE Healthcare Life Sciences, GE Healthcare Europe GmbH, Eindhoven, The Netherlands) suspension were prepare in 50 mM ethylenediamine buffer (pH 7.0). The FITC‐BSA solution and R‐PE solution were mixed in a 1:1 volume ratio before the experiment. 1‐Methylpiperazine buffer solutions (pH 5.0 and pH 4.0) were prepared for the generation of pH gradient of elution buffer solutions in the microfluidic device. After fractionation of proteins, fluorescence images of the 16 reactors were acquired by a Leica I3 filter cube (excitation: BP 450–490 nm; emission: LP 515 nm) to obtain FITC‐BSA fluorescence intensity and a Leica N 2.1 filter cube (excitation: BP 515–560 nm; emission: LP 590 nm) to monitor R‐PE fluorescence intensity.

Rho H.S., Hanke A.T., Ottens M, & Gardeniers H.J. (2018). A microfluidic chip with a staircase pH gradient generator, a packed column and a fraction collector for chromatofocusing of proteins. Electrophoresis, 39(8), 1031-1039.

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