Magnetom sonata maestro class mri system

Subjects were scanned twice, on the 39^th day of each treatment stage, i.e. on the 11^th day of the 2^nd and of the 4^th month (Fig. 1). High-resolution images were obtained with a 1.5 T Siemens Magnetom Sonata Maestro Class MRI System (Siemens, Munich, Germany). Two higher order shimming procedures were completed: the first covering the whole brain, whereas the second covered the orbitofrontal region. Five functional time series of 100 whole-brain images functional scans were performed with an EPI T2*-weighted sequence (TR/TE = 2500/60 ms, flip angle = 90°; FOV = 22 cm, acquisition matrix = 64 × 64, slices thickness = 4 mm). An axial anatomic T1-weighted sequence (TR/TE = 1970/3.93 (ms), inversion time TI = 1100 ms, FOV = 256 mm, acquisition matrix = 256 × 256, slice thickness = 1mm, number of slices = 26) along the anterior commissure/posterior commissure (i.e., AC/PC) line and covering the whole brain was also acquired. For hormonal measures and fMRI data analyses, see Supplemental methods.

Functional images were acquired with a 1.5 T Siemens Magnetom Sonata Maestro Class MRI System (Siemens, Munich, Germany) at the CERMEP in the Groupement Hospitalier Est, Lyon, France. A higher order shimming procedure was completed covering the whole brain of each participant. The imaging parameters for the EPI T2*-weighted sequence were as follows: repetition time (TR), 2500 ms; echo time (TE), 60 ms; flip angle, 90°; FOV, 220 mm, acquisition matrix, 64 × 64, slice thickness = 4 mm. Contiguous slices were acquired in interleaved order. To acquire whole-brain images, the magnetic field was tilted with minus 20° from the anterior to posterior commissure line (AC-PC) of each participant. The imaging parameters for the T1-weighted anatomical scan were as follows: TR, 1970 ms; TE, 3.93 ms; FOV, 256 mm; matrix 256 x 256; slice thickness, 1 mm.
The stimuli were presented with a screen resolution of 1024 × 768 pixels, displayed at a visual angle of 24 × 18°, centered on a 500 × 500 pixel array, and surrounded by a black background. The participants were asked to use their index and middle fingers of both hands to answer by pressing a 4-button controller. Stimuli were presented, and the responses to the stimuli were collected using the software Presentation (Neurobehavioral Systems, CA, USA).