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Way163909

Manufactured by Pfizer
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WAY163909 is a laboratory research tool produced by Pfizer. It functions as a selective agonist for the 5-HT2C serotonin receptor subtype. The product is intended for use in scientific research applications.

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Lab products found in correlation

Sb242084, by Merck Group (3 mentions) Citric acid, by Merck Group (2 mentions) Sb242084, by Bio-Techne (1 mentions) Ketamine, by Merck Group (1 mentions) 2 5 dimethoxy 4 iodoamphetamine, by Merck Group (1 mentions)

Close spelling variants of this product

WAY163909 (WAY) hydrochloride

8 protocols using way163909

1

Pharmaceutical Compound Preparation and Administration

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WAY163909 [(7b-R,10a-R)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta[b][1,4]diazepino[6,7,1hi]indole] was a gift from Pfizer, Inc. (New York, NY) and dissolved in 0.9% NaCl (vehicle employed for comparison to WAY163909). SB242084 [6-chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline dihydrochloride; Sigma Chemical Co., St. Louis, MO, USA] was dissolved in saline containing 10 mmol/L citric acid (Sigma Chemical Co.) and 8% 2-hydroxypropyl-β-cyclodextrin (Trappsol Hydroxpropyl Beta Cyclodextrin, pharmaceutical grade, Cyclodextrin Technologies Development Inc., High Springs, FL, USA) with the final pH of the solution adjusted to 5.6. SB242084, WAY163909, and compound 16 were injected intraperitoneally (ip) at a volume of 1 mL/kg.
Wild C.T., Miszkiel J.M., Wold E.A., Soto C.A., Ding C., Hartley R.M., White M.A., Anastasio N.C., Cunningham K.A, & Zhou J. (2018). Design, Synthesis, and Characterization of 4-Undecylpiperidine-2-carboxamides as Positive Allosteric Modulators of the Serotonin (5-HT) 5-HT2C Receptor. Journal of medicinal chemistry, 62(1), 288-305.
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2

Cocaine and WAY163909 Dissolution Protocol

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(−)-Cocaine (National Institute on Drug Abuse, Research Triangle Park, NC) was dissolved in 0.9% NaCl. WAY163909 [(7b-R,10a-R)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta[b][1,4] diazepino [6,7,1hi]indole] was a gift from Pfizer, Inc. (New York, NY) and was dissolved in 0.9% NaCl (vehicle).
Swinford-Jackson S.E., Anastasio N.C., Fox R.G., Stutz S.J, & Cunningham K.A. (2016). Incubation of cocaine cue reactivity associates with neuroadaptations in the cortical serotonin (5-HT) 5-HT2C receptor (5-HT2CR) system. Neuroscience, 324, 50-61.
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3

Selective 5-HT2C Receptor Modulation

Cited 1 time
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WAY163909 [(7b-R,10a-R)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta[b][1,4] diazepino [6,7,1hi]indole] was a gift from Pfizer, Inc. (New York, NY, United States) and was dissolved in 0.9% NaCl (vehicle, VEH). WAY163909 was tested at a dose range (0–2 mg/kg) that did not alter total horizontal ambulation in a motor activity monitor (3 mg/kg WAY163909 has been shown to significantly suppress total horizontal ambulation) but dose-dependently suppressed operant responding for self-administered sucrose pellets (Cunningham et al., 2011 (link)). These effects are completely blocked following pretreatment with the selective 5-HT2CR antagonist SB242084 (Dunlop et al., 2005 (link); Cunningham et al., 2011 (link)). All injections were administered intraperitoneally (i.p.) in a volume of 1 ml/kg.
Price A.E., Anastasio N.C., Stutz S.J., Hommel J.D, & Cunningham K.A. (2018). Serotonin 5-HT2C Receptor Activation Suppresses Binge Intake and the Reinforcing and Motivational Properties of High-Fat Food. Frontiers in Pharmacology, 9, 821.
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4

Pharmacological Evaluation of WAY163909

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WAY163909 [(7b-R,10a-R)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta[b][1,4] diazepino[6,7,1hi]indole] was a gift from Pfizer, Inc. (New York, NY) and was dissolved in 0.9% NaCl (vehicle employed for comparison to WAY163909). SB242084 [6-chloro-5-methyl-1-[[2-(2-methylpyrid-3-yloxy)pyrid-5-yl]carbamoyl]indoline dihydrochloride; Sigma Chemical Co., St. Louis, MO, USA] was dissolved in saline containing 10 mmol/L citric acid (Sigma Chemical Co.) and 8% 2-hydroxypropyl-β-cyclodextrin (Trappsol hydroxpropyl β cyclodextrin, pharmaceutical grade, Cyclodextrin Technologies Development Inc., High Springs, FL, USA) with the final pH of the solution adjusted to 5.6. SB242084, WAY163909, and compound 12 were injected ip at a volume of 1 mL/kg.
Wold E.A., Garcia E.J., Wild C.T., Miszkiel J.M., Soto C.A., Chen J., Pazdrak K., Fox R.G., Anastasio N.C., Cunningham K.A, & Zhou J. (2020). Discovery of 4-Phenylpiperidine-2-Carboxamide Analogues as Serotonin 5-HT2C Receptor-Positive Allosteric Modulators with Enhanced Drug-like Properties. Journal of medicinal chemistry, 63(14), 7529-7544.
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5

Pharmacological Evaluation of Cocaine and WAY163909

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(–)-Cocaine (National Institute on Drug Abuse) was dissolved in 0.9% NaCl. WAY163909 ((7bR, 10aR)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta-[b][1,4]diazepino [6,7,1hi]indole; a gift from Pfizer, New York, NY, USA) was dissolved in 0.9% NaCl.
Anastasio N.C., Liu S., Maili L., Swinford S.E., Lane S.D., Fox R.G., Hamon S.C., Nielsen D.A., Cunningham K.A, & Moeller F.G. (2014). Variation within the serotonin (5-HT) 5-HT2C receptor system aligns with vulnerability to cocaine cue reactivity. Translational Psychiatry, 4(3), e369-.
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6

Protocol for In Vivo Drug Dissolution

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TAT-r3L4F (3; Ac-YGRKKRRPNPDQKPRRKKKEKR-NH2; pepMic Co., China), lorcaserin [(1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3 benzazepine; Hangzhou Trylead Chemical Technology Co., Ltd, Hangzhou, China], WAY163909 [(7b-R,10a-R)-1,2,3,4,8,9,10,10a-octahydro-7bH-cyclopenta[b][1,4] diazepino [6,7,1hi] indole; gift from Pfizer, Inc., New York, NY], and (-) cocaine (National Institute on Drug Abuse, Research Triangle Park, NC) were dissolved in 0.9% NaCl for in vivo studies.
Soto C.A., Du H.C., Fox R.G., Yang T., Hooson J., Anastasio N.C., Gilbertson S.R, & Cunningham K.A. (2019). In Vivo and In Vitro Analyses of Novel Peptidomimetic Disruptors for the Serotonin 5-HT2C Receptor Interaction With Phosphatase and Tensin Homolog. Frontiers in Pharmacology, 10, 907.
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7

Selective 5-HT2C Receptor Modulators

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SB 242084 (Tocris Bioscience, Bristol, UK) and WAY 163909 (Pfizer) were selected on the basis of their selectivity profiles and previous usage in the laboratory. SB 242084 exhibits 100-fold selectivity for the 5-HT2CR over the 5-HT2BR and 158-fold selectivity for the 5-HT2CR over the 5-HT2AR (Kennett et al. 1997 (link)). WAY 163909 exhibits 46- and 20-fold selectivity for the 5-HT2CR over the 5-HT2BR and 5-HT2AR respectively (Dunlop et al. 2005 (link)). SB 242084 and WAY 163909 were dissolved in 0.9% saline at the required concentrations and volumes and frozen at − 80 °C in aliquots until required. All injections were administered intraperitoneally with a 20-min delay between injection and start of behavioural testing. All injections were administered at an injection volume of 10 ml/kg.
Phillips B.U., Dewan S., Nilsson S.R., Robbins T.W., Heath C.J., Saksida L.M., Bussey T.J, & Alsiö J. (2018). Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice. Psychopharmacology, 235(7), 2101-2111.
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8

Pharmacological Modulation of 5-HT Receptors

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The injectable anesthetic (+/−)-ketamine and the mixed 5-HT2A/2C receptor agonist (+/−)2,5-Dimethoxy-4-iodoamphetamine (DOI) (Fantegrossi et al., 2008 (link)) were purchased from Sigma-Aldrich (St. Louis, MO) and dissolved in saline. The selective 5-HT2C receptor antagonist, SB-242084 (Kennett et al., 1997 (link)), was purchased from SigmaAldrich (St. Louis, MO) and dissolved in 5% Tween 80, 5% ethanol, and brought to final volume in saline. The selective 5-HT2C receptor agonist, WAY-163909 (Grauer et al., 2009 (link); Marquis et al., 2007 (link)), was provided as a gift from Pfizer (New York, NY) and dissolved in 5% Tween 80 and brought to final volume in saline. All injections were administered intraperitoneally at a volume of 0.01 ml of the drug solution per g body weight of each mouse. All doses are reported in the salt form.
Murphy T.J, & Murnane K.S. (2018). The serotonin 2C receptor agonist WAY-163909 attenuates ketamine-induced hypothermia in mice. European journal of pharmacology, 842, 255-261.
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