Ingenia 3.0 cx

In our study, a 3.0-T (Ingenia 3.0CX; Philips Healthcare, Best, The Netherlands) magnetic resonance imaging system and 16-channel coils of the head were used to perform MRI transection scans. Scan sequence: 3D T1W FFE, TR = 6.4 ms, TE = 3.0 ms, FOV = 240 × 240 × 180 mm, reconstruction voxel = 1.1 × 1.1 × 1.1, reconstruction matrix = 400 × 400, slice thickness = 1.1 mm; 3D T2 SE, TR = 2,500 ms, TE = 232 ms, FOV = 250 × 25 × 180 mm, reconstruction voxel = 1.1 × 1.1 × 1.1, reconstruction matrix = 512 × 512, slice thickness = 1.1 mm; 3D FLAIR, TR = 4,800 ms, TE = 244 ms, FOV = 240 × 240 × 173 mm, reconstruction voxel = 1.1 × 1.1 × 1.1, reconstruction matrix = 384 × 384, slice thickness = 1.2 mm; 3DAPTw sequence, TR = 6,300 ms, TE = 8.3 ms, FOV = 230 × 180 × 60 mm, reconstruction voxel = 1.8 × 1.8 × 6, reconstruction matrix = 256 × 256, slice thickness = 6 mm, TSE factor = 174. Each subject underwent the above MRI scan regimen, which took approximately 30 min.

Magnetic resonance images were acquired by a 32-channel 3.0-T MRI scanner (Philips, ingenia 3.0 CX), The T1-weighted three-dimensional images were obtained with the following parameter settings: repetition time (TR) = 6.6 ms, echo time (TE) = 3.0 ms, thickness = 1.0 mm, flip angle = 8°, the field of view (FOV) = 240 mm × 240 mm, matrix = 240 × 240; Functional MR images were acquired across 250 scans with a gradient echo EPI sequence: TR = 2,000 ms, TE = 30 ms, and flip angle = 90°. A total of 33 slices (FOV = 230 mm × 230 mm, matrix = 96 × 94, slice thickness = 3.6 mm, and 250 volumes) aligned along the anterior cingulate and posterior cingulate cortex line were acquired. During the rs-fMRI scans, all participants kept their eyes closed, relaxed, motionless, awake, and of nothing. Routine brain fluid-attenuated inverse recovery (FLAIR) sequence scanning was acquired to exclude other cerebral abnormalities.

The scans were performed using a 3.0 T MRI system (Ingenia 3.0 CX; Philips Healthcare, Best, The Netherlands) with a 16-channel phased-array body coil. The specific scan sequences used can be found in Table 1. During DWI sequence scanning, b values of 0, 100, 400, 800, and 1400 mm/s2 were used, with automatic calculation of the ADC map. Four Regional Saturation Technique slabs were used when APT scanning (9 (link)). A 2-second APT pre-pulse with a saturation power level of B1, rms=2 μT was achieved for APT imaging by transmitting dual radiofrequency channels in an interleaved manner. Nine frequency offsets (4.3 ppm, repeated 3 times at 3.5 ppm, 2.7 ppm, -2.7 ppm, -3.5 ppm, -4.3 ppm, -1560 ppm) relative to the water frequency were acquired for APT Z-spectrum. For the 3.5 ppm acquisition, a Dixon-based method was employed, and the acquisition window was shifted by ±0.4 ms and 0 ms, respectively. A B0 map was calculated from these three images and used for Z-spectrum correction.
The APT(%) calculation method was as follows:
APT(%) = MTRasym (3.5 ppm)(%) = 100%∗ (S − 3.5 ppm−S + 3.5 ppm)÷ S0.
Note: MTRasym (3.5 ppm) is the abbreviation of magnetization transfer ratio asymmetry at 3.5 ppm. S0 represent the signal intensities without saturation pulse.

MRI was performed using two 3T MR scanners. Our conventional brain MRI protocol included the following sequences: axial T2-weighted fast spin-echo imaging with the Dixon technique, axial T1-weighted fluid attenuation inversion recovery imaging (T1-FLAIR), axial T2-weighted fluid attenuation inversion recovery imaging (T2-FLAIR), diffusion-weighted imaging, and susceptibility-weighted imaging with or without contrast-enhanced 3D T1-weighted gradient-echo imaging. The examination of 25 patients was performed on a 3T MR scanner with a 48-channel head coil (Signa^™ Architect; GE Healthcare, Waukesha, WI, USA), whereas the other 20 patients underwent brain MRI using another 3T MR scanner with a 32-channel head coil (Ingenia 3.0 CX; Philips Healthcare, Best, The Netherlands).

Contrast-enhanced neck MR angiography was performed using two different 3T MR scanners. Our contrast-enhanced neck MR angiography was obtained by utilizing the following parameters: repetition time (TR)/echo time (TE), 4.3/1.5 ms; flip angle, 25°; field of view (FOV), 340 × 283 mm; slice thickness, 1.4 mm; voxel size, 1.1 × 1.3 × 1.4 mm; no acceleration, bandwidth, 391 Hz/pixel; and acquisition time, 31 s for Signa™ Architect (GE Healthcare, Waukesha, WI, USA); TR/TE, 3.9/1.5 ms; flip angle, 27°; FOV, 320 × 270 mm; slice thickness, 1.2 mm; voxel size, 0.6 × 0.7 × 1.2 mm; acceleration factor (SENSE), phase (3) and slice (1); bandwidth, 744 Hz/pixel; and acquisition time, 38 s for Ingenia 3.0 CX (Philips Healthcare, Best, The Netherlands). The contrast material used for all the patients was 6–7.5 mL of Gadovist and the flow rate was set at 1.5 mL/s. Immediately after completion of the contrast agent injection, 30 mL of sterile isotonic 0.9% saline solution was injected at a rate of 2 mL/s using a power injector.