1 1 1 3 3 3 hexafluoro 2 propanol hfip

Manufactured by Fluorochem

Sourced in United Kingdom

1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) is a colorless, volatile organic compound. It is a versatile solvent commonly used in various laboratory applications, including polymer synthesis, organic chemistry reactions, and analytical techniques. HFIP has a high polarity and a low surface tension, making it an effective solvent for a wide range of materials. Its chemical formula is C₃H₂F₆O.

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Lab products found in correlation

5 protocols using 1 1 1 3 3 3 hexafluoro 2 propanol hfip

Fabrication of PVP-based Biomaterials

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PVP (M w =360,000 and 1,300,000) was purchased from Sigma-Aldrich, UK. Sebacic acid (≥98%, M w = 202.20) and glycerol (≥99.5%, M w M w = = 92.09) were purchased from Alfa-Aesar, UK. Other chemicals and solvents such as absolute ethanol (99.8%) Acros Organics, dimethylformamide (DMF) (99%) Alfa Aesar and 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) (99%) Fluorochem were utilized without further processing.
Immortalized human skin fibroblast cells (HDF-hTERT) were donated from the MRC Centre for Reproductive Health, Edinburgh, UK. High glucose, pyruvate, Dulbecco's Modified Eagle Medium (DMEM), fetal bovine serum albumin (FBS), non-essential amino acids (NEAA), penicillin-streptomycin and Hanks' Balanced Salt Solution (HBSS) were purchased from Thermo-Fisher Scientific, UK. Glutaraldehyde (GA), hexamethyldisilazane (HDMS), and sucrose were purchased from Alfa-Aesar, UK.

Keirouz A., Fortunato G., Zhang M., Callanan A, & Radacsi N. (2019). Nozzle-free electrospinning of Polyvinylpyrrolidone/Poly(glycerol sebacate) fibrous scaffolds for skin tissue engineering applications. Medical engineering & physics, 71.

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Synthesis of Polylactic Acid Precursors

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Glycolic acid, chloroform, tetrahydrofuran (THF), diphenylether, 3 Å molecular sieves and two catalysts (tin(II) chloride dihydrate and methanesulfonic acid), were purchased from Sigma Aldrich (Seoul, Korea) and were used as received. dl-lactic acid (predominantly containing l-isomer) in 85% to 90% aqueous solutions were acquired commercially from Alfa Aesar (Fisher Scientific Ltd., Incheon, Korea). 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) with a 99% purity was purchased from Fluorochem Ltd. (Derbyshire, UK), and was used as received. The 3 Å molecular sieves was activated using microwave oven (Samsung, Seoul, Korea) prior to use.

Ayyoob M, & Kim Y.J. (2018). Effect of Chemical Composition Variant and Oxygen Plasma Treatments on the Wettability of PLGA Thin Films, Synthesized by Direct Copolycondensation. Polymers, 10(10), 1132.

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Silk Protein Extraction and Purification

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Ethanol, mEthanol, and calcium chloride (CaCl₂) were purchased from Kanto Chemical (Tokyo, Japan). Sodium carbonate (Na₂CO₃) and lithium chloride were purchased from FUJIFILM Wako Pure Chemical (Osaka, Japan). 1-Hexyl-3-methyl-imidazolium chloride ([HMIM][Cl], ≥95% purity) was purchased from Sigma-Aldrich (St. Louis, MO, USA) as the ionic liquid. 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) was purchased from Fluorochem (Derbyshire, UK). All chemical reagents were used without further purification.
Silkworm silk cocoons were kindly donated by Tsuruoka Silk (Yamagata, Japan). Marseilles soap (additive free) was purchased from Miyoshi Soap (Tokyo, Japan). A cellulose dialysis tubing (diameter, 21.4 mm; molecular weight cutoff (MWCO), 12,000–14,000 Da) was purchased from SERVA Electrophoresis (Heidelberg, Germany). Nitrogen (N₂) gas was purchased from Taiyo Nippon Sanso (Tokyo, Japan). Water purification systems (PURELAB flex 3, ELGA LabWater, High Wycombe, UK) were used to obtain ultrapure water.

Satoh R., Morinaga T, & Sato T. (2022). Novel Dry Spinning Process of Natural Macromolecules for Sustainable Fiber Material -1- Proof of the Concept Using Silk Fibroin. Materials, 15(12), 4195.

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Interfacial Polymerization of Sebacoyl Chloride and Ethylenediamine

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Sebacoyl chloride (SC) by Alfa Aesar and ethylene diamine (EDA) by Sigma Aldrich were used as monomers for interfacial polymerization. Dodecane (99%, anhydrous) by Sigma Aldrich, hexane (99%) by Merck and toluene (99.8%) by Fischer Chemicals were used as solvents for SC and water for EDA. Poly(vinyl alcohol) (PVA, 87–90% hydrolyzed,

\bar{M_{W}}

= 30,000–70,000 g mol⁻¹) was used as an emulsifier-stabilizer; 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) by Fluorochem was used as solvent for viscometry measurements. All reagents were commercially available and were used as received.

Mytara A.D., Chronaki K., Nikitakos V., Papaspyrides C.D., Beltsios K, & Vouyiouka S. (2021). Synthesis of Polyamide-Based Microcapsules via Interfacial Polymerization: Effect of Key Process Parameters. Materials, 14(19), 5895.

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Silk Fibroin-based Biomaterials for Tissue Engineering

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Bombyx mori silkworm cocoons were obtained from local sericulture (Oliver Twists Threads Ltd., Kirk Merrington, UK). Sebacic acid (≥98%, Mw = 202.20 g/mol), and glycerol (≥99%, Mw = 92.09 g/mol) were purchased from Alfa-Aeser, UK. Poly(caprolactone) PCL (C6H10O2)n (Mw = 80,000 g/mol) was purchased from Sigma-Aldrich, UK. 1,1,1,3,3,3-Hexafluoro-2-propanol (HFIP) was obtained from Fluorochem, UK. Solvents: absolute ethanol (≥99.5%, EtOH), chloroform (≥99.8%, CF), and formic acid (99%) were purchased from Acros Organics, UK, whereas salts: calcium chloride (CaCl2), sodium carbonate anhydrous (Na2CO3), and lithium bromide (LiBr) were purchased from Thermo-Fisher Scientific, UK.
Immortalized human skin fibroblasts (hTERT, MRC Centre for Cardiovascular Science, Edinburgh, UK) was used for the cell culture experiments. High glucose, pyruvate, Dulbecco's Modified Eagle Medium (DMEM), fetal bovine serum albumin (FBS), non-essential amino acids, penicillinstreptomycin, and Hanks' Balanced Salt Solution (HBSS) were purchased from Thermo-Fisher Scientific, UK. Glutaraldehyde, hexamethyldisilazane (HDMS), and sucrose were purchased from Alfa-Aesar, UK.

Keirouz A., Zakharova M., Kwon J., Robert C., Koutsos V., Callanan A., Chen X., Fortunato G, & Radacsi N. (2020). High-throughput production of silk fibroin-based electrospun fibers as biomaterial for skin tissue engineering applications. Materials science & engineering. C, Materials for biological applications, 112.

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