Spirometry was performed by three well-trained pulmonary technicians following the 1994 ATS recommendations [15 (link)], using a spirometer(Vmax-229, Sensor-Medics, Yorba Linda, CA, USA) for all subjects. The predicted forced expiratory volume in one second (FEV1) and forced vital capacity (FVC) were measured using the method of Morris [16 (link)]; the patients performed forced expiratory maneuvers until three measurements met the ATS guideline recommendations. The subjects performed a maximum of eight forced expirations; those who were unable to perform three expiratory maneuvers that met ATS guidelines were excluded. Two doses of fenoterol hydrobromide (Berotec®, Boehringer Ingelheim, Ingelheim, Germany) 200 μg were administered 1–2 min apart. The forced expirations were repeated 15 min after administration of the bronchodilator.
Berotec
Manufactured by Boehringer Ingelheim
Sourced in Germany
Berotec is a laboratory equipment product manufactured by Boehringer Ingelheim. It is a device used for specific medical or scientific applications. The core function of Berotec is to perform certain tasks or measurements in a laboratory setting.
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Lab products found in correlation
2 protocols using berotec
1
Spirometry Procedure for Lung Function Assessment
2
Pulmonary Function Testing Protocol
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Pulmonary functions were measured using spirometry (Spirolab II®; Medical International Research, Roma, Italy) following the ATS/ERS recommendations,17 (link) and 3 acceptable tests were recorded. The highest forced vital capacity (FVC) and forced expiratory volume in the first second (FEV1) were documented, and percentages of the predicted values were calculated.
For bronchodilator reversibility tests, the children received 200 μg of fenoterol (Berotec®, 100 μg per puff, metered-dose inhaler; Boehringer Ingelheim, Germany) through a valved spacer with a face mask. Two separate doses were delivered at 30-second intervals. FEV1 and FVC values were recorded by spirometry after 2 doses of bronchodilator.
Methacholine challenge tests were performed according to the 2017 ERS technical standard.18 Provocative concentrations causing a 20% fall in FEV1 (PC20) were calculated. PC20 ≤ 4 mg/mL was defined as airway hyperresponsiveness according to the ERS technical standard.
For bronchodilator reversibility tests, the children received 200 μg of fenoterol (Berotec®, 100 μg per puff, metered-dose inhaler; Boehringer Ingelheim, Germany) through a valved spacer with a face mask. Two separate doses were delivered at 30-second intervals. FEV1 and FVC values were recorded by spirometry after 2 doses of bronchodilator.
Methacholine challenge tests were performed according to the 2017 ERS technical standard.18 Provocative concentrations causing a 20% fall in FEV1 (PC20) were calculated. PC20 ≤ 4 mg/mL was defined as airway hyperresponsiveness according to the ERS technical standard.
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