L100 55

Human recombinant insulin, SDS and dibutyl sebacate were acquired from Sigma-Aldrich (St. Louis, MO, USA). STI was bought from Thermo Fisher Scientific (Waltham, MA, USA) and SYLGARD™ 184 silicone elastomer kit from Dow Chemical Company (Midland, MI, USA). Eudragit ® L 100 and L100-55 were both obtained from Evonik (Essen, Germany).
Midazolam (5 mg mL -1 ) was procured from Hameln (Gloucester, UK) whereas Hypnorm (fentanyl, 0.315 mg mL -1 ; fluanisone 10 mg mL -1 ) was acquired from Skanderborg Pharmacy (Skanderborg, Denmark), and pentobarbital/Euthanimal (400 mg mL -1 ) from Alfasan (Woerden, Netherlands). All additional chemicals and solvents were at least of analytical grade and obtained from commercial suppliers. Ultrapure water was used throughout the studies purified by an Ultra Clear UV system (Evoqua Water Technologies, Pittsburgh, PA, USA).

Naproxen and Itraconazole were purchased from SRIS Pharmaceuticals (Hyderabad, India). Hydroxypropylmethylcellulose phthalate (HPMCP HP50) and hydroxypropylmethylcellulose acetate succinate fine grade (HPMCAS-LF) were obtained from Shin-Etsu (Tokyo, Japan). Copolymer of N-vinyl-2-pyrrolidone and vinyl acetate (PVPVA) was obtained from Ashland (Covington, KY, USA) and polyvinylpyrrolidone (PVPK30) was purchased from VWR (Heverlee, Belgium).
Copolymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer (Soluplus) was donated by BASF (Ludwigshafen am Rhein, Germany).
Copolymer of methacrylic acid and methyl methacrylate 1:1 (Eudragit L100) and copolymer of methacrylic acid and ethyl acrylate copolymer 1:1 (Eudragit L100-55) were donated by Evonik (Essen, Germany). The solvents used were of analytical or HPLC grade.