Levothyroxine sodium tablets

After total or near-total thyroidectomy, the control group received levothyroxine sodium tablets, and the experimental group received levothyroxine sodium tablets plus I 131.
Control group: 1 month after the operation, the patients took levothyroxine sodium tablets (approval number H20140052, Merck, Germany) 100 μg every day, and the dose was adjusted according to the actual thyroid function of the patients.
Experimental group: the patients were prohibited from thyroid hormone, iodine-containing diet, and iodine alcohol within 3-4 weeks after operation. Examinations such as neck ultrasonography and I 131 uptake rates for thyroid testing were performed. On the basis of the treatment plan of the control group, 3-4 weeks after the operation, I 131 (approval number H10983121, Chengdu China Qualcomm Isotope Co. Ltd.) was orally administered once when the surgical wound was healed. The dose was 3.7 GBq/d for patients without metastases and 5.55 GBq/d for patients with metastases. 131-iodine whole-body imaging was performed 5–7 days after dosing.

This is a prospective, randomized controlled clinical trial with three parallel arms. We will recruit 120 patients from The Longhua Hospital affiliated to Shanghai University of Chinese Medicine. All patients will be randomly assigned to the experimental group (Pingmu Decoction + acupuncture), control group 1 (Chinese medicine group) and control group 2 (acupuncture group). All patients will maintain basic treatment for thyroid-related eye disease: methimazole and levothyroxine sodium tablets (both from Merck & Co, LTD, Germany). Dosage will be adjusted every 28 days according to the patient's thyroid function level. Control group 1 (Chinese medicine group), Pingmu Decoction will be required to take orally twice a day, 1 bag each time., control group 2 (acupuncture group) will be treated with acupuncture alone. The experimental group was treated with pingmu Decoction combined with acupuncture. All treatments will be administered for 12 weeks.

All patients will maintain the basic treatment: methimazole and levothyroxine sodium tablets (both from Merck & Co, LTD, Germany). Dosage will be adjusted every 28 days according to the patient's thyroid function level.
Experimental group: Pingmu Decoction combined with acupuncture treatment.(Acupuncture points: Shangtianzhu, Fengchi, Sanyinjiao, Hegu, Waiguan and Yangbai are the main points, together with Cuanzhu on the head and face, Yuyao acupoints, Sizhukong acupoints, Toulinqi acupoints, Qiuhou acupoints, Qingming acupoints, Fengchi acupoints and opticoels. The index finger will be taken dajian acupoints, xiaojian acupoints wood acupoints;the pinkies will be taken Yanhuang acupoints, Huoxi acupoints;the legs will be taken Yichong acupoints. Erchong acupoints and Sanchong acupoints. Calvaria will select Baihui acupoint. All acupoints will be pierced vertically except Cuanzhu. Yuyao and Sizhukong acupoints. Frequency of acupuncture treatment: 45 minutes of needle retention twice a week). Control group 1: (Pingmu Decoction group): Patients will be given Pingmu decoction orally, 2 times a day, 1 bag each time. Control group 2 (acupuncture group): The patients will be treated only with acupuncture(acupuncture and moxibustion locations are the same as those of the experimental group). The course of treatment will be 12 weeks.