Her2 antibody ab 17

Manufactured by Thermo Fisher Scientific

The HER2 antibody (Ab-17) is a laboratory reagent used for the detection and analysis of the human epidermal growth factor receptor 2 (HER2) protein in biological samples. It is a monoclonal antibody that specifically binds to the HER2 protein.

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Lab products found in correlation

Ki 67 clone mib 1, by Agilent Technologies (1 mentions) Phospho akt ser473, by Merck Group (1 mentions) Afatinib, by Selleck Chemicals (1 mentions) Tucatinib, by Selleck Chemicals (1 mentions) Poziotinib, by Selleck Chemicals (1 mentions) Pyrotinib, by MedChemExpress (1 mentions)

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HER2 antibody (3 citations)

2 protocols using her2 antibody ab 17

Antibody Reagents for Western Blot and IHC

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Antibodies for western blots were purchased from Cell Signaling Technologies: phospho PLCγ (Tyr783), PLCγ, phospho EGFR (Tyr1173), EGFR, phospho p44/42 MAPK (Thr202/Tyr204), p44/42 MAPK, phospho Akt (Ser473), and Akt; Millipore: phospho HER2 (pY1248); and Thermo Fisher: HER2 antibody (Ab-17). Antibodies for immunohistochemistry were purchased from Cell Signaling Technology (phospho-S6 Ser235/236, clone D57.2.2E; phospho-ERK1/2 Thr202/Tyr204, clone D13.14.4E) or Dako (Ki-67, clone MIB-1). Cetuximab, panitumumab, trastuzumab, and lapatinib were obtained from the hospital pharmacy. Afatinib was obtained from Selleckchem (Houston, TX). Neratinib was provided by Puma Biotechnology, Inc. under a Materials Transfer Agreement.

Kavuri S.M., Jain N., Galimi F., Cottino F., Leto S.M., Migliardi G., Searleman A.C., Shen W., Monsey J., Trusolino L., Jacobs S.A., Bertotti A, & Bose R. (2015). HER2 activating mutations are targets for colorectal cancer treatment. Cancer discovery, 5(8), 832-841.

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HER2-targeting Antibody Immunoblotting

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Antibodies used for immunoblotting were purchased from Cell Signaling Technologies: phospho-HER2 (1248), phospho-p44/42 MAPK (Thr202/Tyr204), p44/42 MAPK, phospho-Akt (Ser473), Akt, phospho-S6 (240-44 (link)), phospho-S6 (235-236), phospho-MTOR, phospho-S6 (Thr 389), E-Cadherin (24E10); from Millipore: phosphoHER2 (pY1248); from Sigma: monoclonal Anti-β-Actin; and from Thermo Fisher: HER2 antibody (Ab-17). Poziotinib and tucatinib were obtained from Selleckchem. Pyrotinib was obtained from MedChem Express. Neratinib was provided by Puma Biotechnology, Inc., under a Materials Transfer Agreement.

Kalra R., Chen C.H., Wang J., Salam A.B., Dobrolecki L.E., Lewis A., Sallas C., Yates C.C., Gutierrez C., Karanam B., Anurag M., Lim B., Ellis M.J, & Kavuri S.M. (2022). Poziotinib Inhibits HER2-Mutant–Driven Therapeutic Resistance and Multiorgan Metastasis in Breast Cancer. Cancer Research, 82(16), 2928-2939.

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