Optima mri scanner

MR imaging was performed using a 3T Achieva dStream MRI scanner (Philips Healthcare, Best, Netherlands), a 1.5 T Optima MRI scanner (General Electric Healthcare, Milwaukee, WI, USA), or a 1.5 T Magnetom Avanto Fit (Siemens Healthineers, Erlangen, Germany).
Briefly, standard imaging included diffusion-weighted imaging (DWI) (b0 and b1000 with apparent diffusion coefficient (ADC) map), T2-weighted fluid-attenuated inversion recovery (T2-FLAIR) sequence, and a 3D-T1-weighted MRI scan after injection (T1-GD) of a standard dose of contrast agent (Gd-DTPA; 0.1 mmol/kg body weight). For perfusion-weighted imaging, dynamic susceptibility-weighted contrast-enhanced T2* (PWI) was achieved. Parametric maps of relative cerebral blood volume corrected for contrast leakage (rCBV) and of a permeability estimation map (K2) were created from PWI using (v3.0 Olea Medical, La Ciotat, France) [18 (link),19 (link)].

MRIs were performed using a 1.5 T Optima MRI scanner (General Electric Medical Systems, Chicago, IL, USA) or a 1.5 T Magnetom Avanto Fit (Siemens healthineers, Knoxville, TN, USA) or a 3T Achieva dStream MRI (Philips Healthcare, Best, The Netherlands). Succinctly, diffusion-weighted imaging (DWI) with b0 and b1000 was performed. Apparent diffusion coefficient (ADC) maps were calculated. A T2-weighted fluid-attenuated inversion recovery (T2FLAIR) sequence was performed. A T1-weighted MRI (T1Gado) scan was acquired after injection of a standard dose of contrast agent (Gd-DTPA; 0.1 mmol/kg body weight). Perfusion-weighted imaging (PWI) was performed with dynamic susceptibility contrast MR perfusion. Maps depicting relative cerebral blood volume adjusted for contrast leakage (rCBV) and a map estimating permeability (k2) were produced from perfusion-weighted imaging (PWI) data using Olea software version 3.0 from Olea Medical, located in La Ciotat, France [20 (link),21 (link)]. The Supplementary Table S1 provides further details on MRI acquisition parameters for the mainly used MRI scanners.