Perfluorohexanoic acid pfhxa

Manufactured by Merck Group

Sourced in United States, Germany, Switzerland

Perfluorohexanoic acid (PFHxA) is a fluorinated organic compound with the chemical formula C6HF11O2. It is a colorless, odorless, and dense liquid used in various industrial and research applications. PFHxA serves as a building block for the synthesis of other fluorinated compounds and is commonly employed as a surfactant and chemical intermediate.

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4 protocols using perfluorohexanoic acid pfhxa

Fluorinated Compounds Characterization

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Perfluorobutanoic acid (PFBA; CAS# 375–22-4, 98%) and perfluorobutane sulfonic acid (PFBS; CAS# 375–73-5, 98% purity) were purchased from TCI America. Perfluorooctanoic acid (PFOA; CAS# 335–67-1, 98%) was purchased from AIKE Reagent. Sodium perfluorooctanoate (Na-PFOA; CAS# 335–95-5, 97%) was purchased from Manchester Organics. Potassium perfluorooctane sulfonate (K-PFOS; CAS# 1763–23-1, 98%) was purchased from Matrix Scientific. Perfluorohexanoic acid (PFHxA; CAS# 307–24-4, 97%), perfluoroheptanoic acid (PFHpA; CAS#375–85-9, 99%), potassium perfluorohexane sulfonate (K-PFHxS; CAS# 3871–99-6, >98%), and perfluorooctane sulfonic acid (PFOS; CAS# 1763–23-1, 98%), were purchased from Sigma Aldrich.Perfluorononanoic acid (PFNA; CAS#375–95-1, 97%) was purchased from Shanghai Macklin Biochemical Co., Ltd. Perfluorodecanoic acid (PFDA; CAS#335–76-2, 98%) was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.
All background solutions were prepared with distilled, deionized water. Measurements were conducted with background solutions of 0.01 M NaCl or SGW. The SGW pH is 7.7 and ionic strength is 0.01 M, and it is comprised of the cations (concentration in mg/L) Na⁺¹ (50), Ca⁺² (36), and Mg⁺² (25), and anions NO₃⁻¹ (6), Cl⁻¹ (60), CO₃⁻²/HCO₃⁻¹ (133), and SO₄⁻² (99).

Brusseau M.L, & Van Glubt S. (2021). THE INFLUENCE OF MOLECULAR STRUCTURE ON PFAS ADSORPTION AT AIR-WATER INTERFACES IN ELECTROLYTE SOLUTIONS. Chemosphere, 281, 130829.

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Binding of PFCAs to Human Serum Albumin

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All chemicals and reagents were of analytical grade, including fatty acid-free HSA (A1887, lyophilized powder, Sigma-Aldrich, St. Louis, MO, USA), perfluorobutanoic acid (PFBA, 98%, Sigma-Aldrich, St. Louis, MO, USA), perfluorohexanoic acid (PFHxA, 98%, Sigma-Aldrich, St. Louis, MO, USA), PFOA (98%, Chemical Industry, Tokyo, Japan), perfluorodecanoic acid (PFDA, 98%, Sigma-Aldrich, St. Louis, MO, USA). The stock solution of each PFCA was prepared in phosphate-buffered saline (PBS, pH 7.4 ± 0.1). HSA solution was freshly prepared in PBS (pH 7.4 ± 0.1) 15 min before use. In order to prevent PFCAs from adsorbing to glass surface, polypropylene containers were used.

Chen H., Wang Q., Cai Y., Yuan R., Wang F, & Zhou B. (2020). Investigation of the Interaction Mechanism of Perfluoroalkyl Carboxylic Acids with Human Serum Albumin by Spectroscopic Methods. International Journal of Environmental Research and Public Health, 17(4), 1319.

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Characterizing Pharmaceutical Standards for Research

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Perfluorooctanoic acid (PFOA) (purity ≥ 95%), perfluorooctanesulfonic acid (PFOS) (purity ≥ 98%), perfluorohexanoic acid (PFHxA) (purity ≥ 97%), perfluorohexanesulfonic acid (PFHxS) (purity ≥ 98%), perfluorobutanoic acid (PFBA) (purity ≥ 99%), perfluorobutanesulfonic acid (PFBS) (purity ≥ 97%), perfluorononanoic acid (PFNA) (purity ≥ 97%) and perfluorodecanoic acid (PFDA) (purity ≥ 98%) were obtained from Sigma-Aldrich (Taufkirchen, Germany). Ammonium perfluoro-(2-methyl-3-oxahexanoate) (HFPO-DA, also known as GenX) (purity 99%) was obtained from Apollo Scientific (Cheshire, UK). 3H-perfluoro-3-[(3-methoxypropoxy) propanoic acid] (PMPP, also known as Adona) (purity > 98%) was obtained from Campro Scientific (Berlin, Germany).
Cyclosporine A (purity of 99%) was obtained from Biomol (Hamburg, Germany). Nefazodone (purity ≥ 98%), sodium deoxycholate (purity ≥ 97%), glycocholic acid hydrate (purity ≥ 97%), sodium glycochenodeoxycholate (purity ≥ 97%), sodium chenodeoxycholate (purity ≥ 97%), and sodium glycodeoxycholate (purity ≥ 97%) were purchased from Sigma-Aldrich (Taufkirchen, Germany). Dimethyl sulfoxide (DMSO), GW7647, SR12813 and CITCO were purchased from Merck (Darmstadt, Germany). Rosiglitazone (purity ≥ 98%) was obtained from Cayman (Ann Arbor, USA).

Sadrabadi F., Alarcan J., Sprenger H., Braeuning A, & Buhrke T. (2023). Impact of perfluoroalkyl substances (PFAS) and PFAS mixtures on lipid metabolism in differentiated HepaRG cells as a model for human hepatocytes. Archives of Toxicology, 98(2), 507-524.

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PFAS Quantification in Aqueous Samples

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Barium stock solution was prepared from barium nitrate, BaNO 3 salt (BDH, UK). Seven PFAS standards were examined in this study including perfluorohexanoic acid (PFHxA) (Sigma-Aldrich, Switzerland), perfluoroheptanoic acid (PFHpA) (Sigma-Aldrich, Rusia), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA) (Sigma-Aldrich, USA), perfluorooctanesulfonic acid (PFOS) (Wellington, Canada) and methyl perfluorooctanoate (Me-PFOA) (Alfa-Aesar, UK). Oasis WAX (6 cc, 150 mg, 30 µm) solid-phase extraction (SPE) were purchased from Waters, UK. HPLC grade of methanol and acetonitrile were from Honeywell Riedel-de Haen, Germany, ammonium acetate was from Sigma-Aldrich, Germany, formic acid from Fluka, USA and ammonium hydroxide solution from Sigma-Aldrich, UK. Deionised water (18 MΩ cm, Smart2Pure, Thermo Fisher Scientific) was used throughout the study.

Jamari N.L.A., Dohmann J.F., Raab A., Krupp E.M, & Feldmann J. (2019). Novel non-targeted analysis of perfluorinated compounds using fluorine-specific detection regardless of their ionisability (HPLC-ICPMS/MS-ESI-MS). Analytica chimica acta, 1053.

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