We purchased tetrodotoxin (TTX) from Biotium (Hayward, CA, United States), and AP-5, CGP55845A and DNQX, U-50488, and nor-binaltorphimine from Tocris (Bristol, United Kingdom) for the electrophysiological recordings. Stock solutions of the drugs were prepared in either distilled water or dimethyl sulfoxide (DMSO) and added to the bath solution to achieve the desired concentration.
Tetrodotoxin ttx
Tetrodotoxin (TTX) is a potent neurotoxin that selectively blocks sodium channels, preventing the generation and propagation of action potentials in nerve and muscle cells. It is a naturally occurring compound found in various marine organisms, including certain species of pufferfish, newts, and some other animals. TTX is commonly used as a research tool to study the role of sodium channels in cellular physiology and neuroscience.
2 protocols using tetrodotoxin ttx
Pharmacological Evaluation of Novel Psychoactive Substances
We purchased tetrodotoxin (TTX) from Biotium (Hayward, CA, United States), and AP-5, CGP55845A and DNQX, U-50488, and nor-binaltorphimine from Tocris (Bristol, United Kingdom) for the electrophysiological recordings. Stock solutions of the drugs were prepared in either distilled water or dimethyl sulfoxide (DMSO) and added to the bath solution to achieve the desired concentration.
Modulation of Neuronal Activity
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