B6 c h2d bbyj b6 h2d mice

Mice were housed in the Center for Comparative Physiology at the Feinstein Institutes for Medical Research. C57BL/6 (B6) and B6.C-H2d/bByJ (B6.H2^d) mice were purchased from The Jackson Laboratory. RAGE KO mice were a generous gift from Kevin Tracey, MD, of the Feinstein Institutes for Medical Research. LAIR-1 cKO mice were generated by crossing B6.129P2-Lyz2^tm1(cre)Ifo/J with B6.Cg-Lair1^tm1Jco/J (The Jackson Laboratory) after backcrossing onto the B6.H2^d background. B6.Cg-Tg(Camk2a-cre)T29–1Stl/J and Hmgb1^tm1.1Rshw/J (Jackson Laboratories) were crossed with in house B6.H2^d mice to generate Camk2a-cre HMGB1^fl/fl B6.H2^d mice. All procedures using mice were conducted using protocols approved by The Feinstein Institutes of Medical Research IACUC (Protocols 2009–048 and 2022–023).

B6.C-H2^d/bByJ (B6.H2^d) mice (Cat# 000359) (44 ) and B6(Cg)-C1qa^{tm1d(EUCOMM)Wtsi}/TennJ (C1qa^−/−) mice (Cat# 031675) (22 (link)) originated from the Jackson Laboratory. B6-background mice were bred with B6.H2^d mice and progeny were crossed to produce mice with homozygous expression of H2^d MHC antigens for use in experiments (6 (link)). B6.ConK^d-on and B6.Tg(CD2-Tcra,-Tcrb)75Bucy (TCR75) mice were provided by J. Zimring (21 (link), 45 (link)). BALB/c mice were from Charles River Laboratories (Cat# 028). B6;SJL-Tg(FCGR2A)11Mkz/J mice (expressing human FCGR2A isoform R131, Jackson Laboratory Cat# 003542) (27 ) were backcrossed to B6 congenicity (46 (link)). Male mice were used as female mice are not susceptible to 34-1-2S-mediated injury (5 (link)). Mice were studied at 8-16 weeks of age after maintenance in the UCSF specific pathogen-free animal facility for at least 2 weeks. Procedures received ethical approval from the UCSF IACUC committee.