400 mr spectrometer

Manufactured by Shimadzu

Sourced in Canada

The Shimadzu 400-MR spectrometer is a compact and versatile instrument designed for efficient spectroscopic analysis. It is capable of conducting precise measurements across a wide range of wavelengths, making it suitable for various applications in research and industrial settings.

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Lab products found in correlation

Agilent 6550 ifunnel quadrupole time of flight q tof mass spectrometer, by Agilent Technologies (2 mentions) Lcms 2020, by Shimadzu (2 mentions) Prominence hplc, by Shimadzu (2 mentions) Prominence hplc, by Phenomenex (1 mentions) C18 column, by Phenomenex (1 mentions)

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Spectrometers (2 citations)

3 protocols using 400 mr spectrometer

Characterization of Synthesized Compounds

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All reagents were purchased from Alfa Aesar (Ward Hill, MA) or
Aldrich (Milwaukee, WI). Compounds were characterized by ¹H NMR on a Varian (Palo Alto, CA) 400-MR spectrometer, and the purities
monitored by a Shimadzu Prominence HPLC with a Phenomenex C18 column
(4.6 mm × 250 mm, methanol/H₂O 60:40, monitored at
254 and 280 nm). The purities of all compounds were found to be >95%.

Liu Z., Yao Y., Kogiso M., Zheng B., Deng L., Qiu J.J., Dong S., Lv H., Gallo J.M., Li X.N, & Song Y. (2014). Inhibition of Cancer-Associated Mutant Isocitrate Dehydrogenases: Synthesis, Structure–Activity Relationship, and Selective Antitumor Activity. Journal of Medicinal Chemistry, 57(20), 8307-8318.

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Synthesis and Characterization of Potent Inhibitors

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All chemicals for synthesis were purchased from Alfa Aesar (Ward Hill, MA) or Aldrich (Milwaukee, WI). The identity of the synthesized compounds was characterized by ¹H and ¹³C NMR on a Varian (Palo Alto, CA) 400-MR spectrometer and mass spectrometer (Shimadzu LCMS-2020). The identity of the potent inhibitors was confirmed with high resolution mass spectra (HRMS) using an Agilent 6550 iFunnel quadrupole-time-of-flight (Q-TOF) mass spectrometer with electrospray ionization (ESI). The purities of the final compounds were determined to be >95% with a Shimadzu Prominence HPLC using a Zorbax C18 (or C8) column (4.6 × 250 mm) monitored by UV at 254 nm.

Wu F., Hua Y., Kaochar S., Nie S., Lin Y.L., Yao Y., Wu J., Wu X., Fu X., Schiff R., Davis C.M., Robertson M., Ehli E.A., Coarfa C., Mitsiades N, & Song Y. (2020). Discovery, Structure-Activity Relationship and Biological Activity of Histone-Competitive Inhibitors of Histone Acetyltransferases P300/CBP. Journal of medicinal chemistry, 63(9), 4716-4731.

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Characterization of Synthetic Compounds

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All chemicals for synthesis were purchased from Alfa Aesar (Ward Hill, MA) or Aldrich (Milwaukee, WI). The identity of the synthesized compounds was characterized by ¹H and ¹³C NMR on a Varian (Palo Alto, CA) 400-MR spectrometer and mass spectrometer (Shimadzu LCMS-2020). The identity the most potent compounds was confirmed with high resolution mass spectra (HRMS) using an Agilent 6550 iFunnel quadrupole-time-of-flight (Q-TOF) mass spectrometer with electrospray ionization (ESI). The purities of the final compounds were determined to be > 95% with a Shimadzu Prominence HPLC using a Zorbax C18 (or C8) column (4.6 × 250 mm) monitored by UV at 254 nm. Synthesis and characterization of compounds can be found in Supplemental Material.

Li X., Yao Y., Wu F, & Song Y. (2022). A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth. Journal of Hematology & Oncology, 15, 41.

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