Compound 3

Manufactured by Cayman Chemical

Compound 3 is a chemical compound manufactured by Cayman Chemical. It serves as a laboratory reagent for research purposes. The core function of Compound 3 is to facilitate specific chemical reactions and analyses in a controlled laboratory environment. Further details on the intended use of this product are not available.

Automatically generated - may contain errors

Lab products found in correlation

Poly 1 c, by Merck Group (2 mentions) Sagm small airway epithelial cell growth medium, by Lonza (1 mentions) Compound 1, by Cayman Chemical (1 mentions) Small airway epithelial cell growth medium, by Lonza (1 mentions)

2 protocols using compound 3

Immortalized hSAEC Culture Protocol

Cited 1 time

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Immortalized hSAECs were previously described.^{37 (link),38 (link)} hSAECs were grown in SAGM small airway epithelial cell growth medium (Lonza, Walkersville, MD) in a humidified atmosphere of 5% CO₂. Poly(I:C) was obtained from Sigma (St. Louis, MO) and used at 10 μg/mL in the cell culture. Compound 1 was purchased from Tocris and compound 3 was either purchased from Cayman Chemical (Ann Arbor, Michigan) or resynthesized in house. Compounds were dissolved in DMSO and added at the indicated concentrations.

Liu Z., Chen H., Wang P., Li Y., Wold E.A., Leonard P.G., Joseph S., Brasier A.R., Tian B, & Zhou J. (2020). Discovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation. Journal of medicinal chemistry, 63(10), 5242-5256.

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Immortalized Human Small Airway Epithelial Cell Culture

Cited 1 time

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Immortalized human small airway epithelial cells (hSAECs) were previously described.^{9 (link)} hSAECs were grown in small airway epithelial cell growth medium (Lonza, Walkersville, MD) in a humidified atmosphere of 5% CO₂. Poly(I:C) was obtained from Sigma (St. Louis, MO) and used at 10 μg/mL in cell culture. Compound 1 was purchased from Tocris, and compound 3 was purchased from Cayman Chemical (Ann Arbor, Michigan). Compounds were solubilized in DMSO and added at the indicated concentrations.

Liu Z., Li Y., Chen H., Lai H.T., Wang P., Wu S.Y., Wold E.A., Leonard P.G., Joseph S., Hu H., Chiang C.M., Brasier A.R., Tian B, & Zhou J. (2022). Discovery, X‑ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site. Journal of medicinal chemistry, 65(3), 2388-2408.

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