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B6.129s2 ighmtm1cgn j mt

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B6.129S2-Ighmtm1Cgn/J (µMT) is a strain of genetically modified mice that lack functional B cells. The mutation in the Igh gene prevents the expression of functional immunoglobulin heavy chains, which are essential for B cell development. This mouse strain is commonly used in research as a model to study the role of B cells in various biological processes.

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Lab products found in correlation

B6.129s7 ifngtm1ts j, by Jackson ImmunoResearch (1 mentions) B6 sjl ptprca pepcb boyj, by Jackson ImmunoResearch (1 mentions) B6.129s7 ifngr1tm1agt j, by Jackson ImmunoResearch (1 mentions) B6.129p2 cxcr3tm1dgen j, by Jackson ImmunoResearch (1 mentions) B6.129p2 ccr5tm1kuz j, by Jackson ImmunoResearch (1 mentions) B6 pl thy1a cyj, by Jackson ImmunoResearch (1 mentions) C57bl 6j, by Jackson ImmunoResearch (1 mentions) Isoflurane, by Baxter (1 mentions)

2 protocols using b6.129s2 ighmtm1cgn j mt

1

Genetically Modified Mouse Strains

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C57BL/6J, B6.PL-Thy1a/CyJ (CD90.1), B6.SJL-Ptprca Pepcb/BoyJ (CD45.1), B6.129S2-Ighmtm1Cgn/J (µMT), B6.129S7-Ifngtm1Ts/J (IFNγ−/−), B6.129S7-Ifngr1tm1Agt/J (IFNγR−/−), B6.129P2-Ccr5tm1kuz/J (CCR5−/−), and B6.129P2-Cxcr3tm1Dgen/J (CXCR3−/−) were purchased from The Jackson Laboratory (Bar Harbor, ME). NR1 transgenic mice expressing a TCR transgene specific for the C. trachomatis antigen Cta1133–152 have been described previously (25 (link)). CXCR3−/−CCR5−/− mice were generated by crossing CXCR3−/− and CCR5−/− mice. Mice were maintained within the Harvard Medical School Center for Animal Resources and Comparative Medicine. All experiments in this report were approved by Harvard’s Institutional Animal Care and Use Committee.
Nogueira C.V., Zhang X., Giovannone N., Sennott E.L, & Starnbach M.N. (2015). Protective immunity against Chlamydia trachomatis can engage both CD4+ and CD8+ T cells and bridge the respiratory and genital mucosae. Journal of immunology (Baltimore, Md. : 1950), 194(5), 2319-2329.
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2

Mouse Model Study Protocol

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Six- to eight-week-old female C57BL/6 mice (Harlan Laboratories, Inc, Indianapolis, IN, USA) and B-cell knock-out (KO) mice, B6.129S2-Ighmtm1Cgn/J, (µMT) [16 (link)] (The Jackson Laboratory Bar Harbor, ME, USA) were used in all experiments. Isoflurane (Baxter, Kista, Sweden) was used as anesthesia.
Görander S., Ekblad M., Bergström T, & Liljeqvist J.Å. (2014). Anti-Glycoprotein G Antibodies of Herpes Simplex Virus 2 Contribute to Complete Protection after Vaccination in Mice and Induce Antibody-Dependent Cellular Cytotoxicity and Complement-Mediated Cytolysis. Viruses, 6(11), 4358-4372.
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