99mtc mdp

Manufactured by Fujifilm

Sourced in Japan

99mTc-MDP is a radiopharmaceutical used in nuclear medicine imaging. It is a technetium-99m (99mTc) labeled compound that binds to hydroxyapatite in bone, allowing visualization of skeletal structures through gamma camera imaging.

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Lab products found in correlation

Symbia intevo, by Siemens (1 mentions) Xspect quant, by Siemens (1 mentions) Symbia t or t6, by Siemens (1 mentions) Bonenavi version 2, by Fujifilm (1 mentions)

3 protocols using 99mtc mdp

Bone Scintigraphy Protocol for Calculating ANN and BSI

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Bone scintigraphy was performed by intravenously administering 99m Tc-MDP (Fujifilm RI Pharma Co., Tokyo, Japan) 370-925 MBq; 3 hours later, horizontal images (anterior and posterior) were taken using a scintillation camera (ECAM and GX7200, Toshiba Corp., Tokyo, Japan). The ECAM imaging rate was 18 cm/min and the image matrix size was 256 × 1024. The GX7200 imaging rate was 17.5 cm/min and image matrix was 256 × 1024. Both devices used a parallel multihole collimator. The data acquisition window was 10% of both ends of the 140 KeV gamma ray emitted by 99m Tc-MDP.
Both BONENAVI version 1 (Fujifilm RI Pharma) and BONENAVI version 2 (Fujifilm RI Pharma) were used to calculate artificial neural networks (ANN), bone scan index (BSI), and hot-spot values from the bone scintigraphy data (Fig. 1). F1 Fig. 1: Method case selection.

Okada Y., Matsushita S., Nakajima Y., Yamaguchi K., Okuda I., Kojima Y, & Tsugawa K. (2019). Comparison of diagnostic precision for bone metastasis of primary breast cancer between BONENAVI version 1 and BONENAVI version 2. Nuclear medicine communications, 40(11).

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Quantitative Bone SPECT/CT Imaging

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BS was performed approximately 3–4 h after intravenous injection of 740 MBq technetium-99m methylene diphosphonate (^99mTc-MDP, Fujifilm RI Pharma Co. Ltd., Tokyo, Japan). Whole-body images were obtained using a gamma camera (Symbia Intevo, Siemens Healthcare, Tokyo, Japan). Bone SPECT/CT was performed after taking whole-body images.
SPECT scans were acquired using low-energy high-resolution collimation, a 256 × 256 matrix of 2.4-mm pixel size, and a total of 120 projections over 360° with a duration of 10 s/view. CT scans were performed with 130 kV and 80 mAs using adaptive dose modulation (CARE Dose 4D). The CT data were reconstructed with 3-mm slice thickness using medium sharp and attenuation kernels (B50s and B31s, respectively).
Quantitative SPECT images were reconstructed using a Siemens “xSPECT Quant” [18 , 19 (link)], with an ordered subset conjugate gradient maximization (OSCGM) algorithm with one subset, thirty iterations, and 6 mm gaussian-filter.

Umeda T., Koizumi M., Fukai S., Miyaji N., Motegi K., Nakazawa S, & Takiguchi T. (2017). Evaluation of bone metastatic burden by bone SPECT/CT in metastatic prostate cancer patients: defining threshold value for total bone uptake and assessment in radium-223 treated patients. Annals of Nuclear Medicine, 32(2), 105-113.

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Technetium-99m Bone Scintigraphy Protocol

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^99mTc-bone scintigraphy was performed 3 h after intravenous injection of 200–290 MBq ^99mTc-HMDP (Nihon Medi-Physics Co., Ltd) or 200–290 MBq ^99mTc-MDP (FUJI FILM RI Pharma Co., Ltd). Anterior and posterior whole-body planar images and SPECT images were obtained using a dual-head gamma camera (Symbia T or T6, Siemens Healthcare, Erlangen, Germany). The low energy high resolution collimator (LEHR) was set on the SPECT equipment. Syngo MI Application 2009A was used as a reconstruction software.

Ishiguchi H., Ito S., Kato K., Sakurai Y., Kawai H., Fujita N., Abe S., Narita A., Nishio N., Muramatsu H., Takahashi Y, & Naganawa S. (2018). Diagnostic performance of 18F-FDG PET/CT and whole-body diffusion-weighted imaging with background body suppression (DWIBS) in detection of lymph node and bone metastases from pediatric neuroblastoma. Annals of Nuclear Medicine, 32(5), 348-362.

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