Female sprague dawley rats

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The Female Sprague Dawley rats are a widely used laboratory animal model. They are a strain of albino rats that originate from the Sprague Dawley company. These rats are commonly used in various types of scientific research and studies.

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Lab products found in correlation

Male sprague dawley rats, by Inotiv (2 mentions) Placebo pellet, by Innovative Research (1 mentions) 8640 teklad 22 5 rodent diet, by Inotiv (1 mentions) Tamoxifen, by Merck Group (1 mentions) Naproxen, by Merck Group (1 mentions) 3 0 vicryl, by Johnson & Johnson (1 mentions) 4 0 nylon suture, by Johnson & Johnson (1 mentions) Td 88238, by Inotiv (1 mentions) Td 88239, by Inotiv (1 mentions)

Close spelling variants of this product

Sprague-Dawley rats (506 citations) Sprague-Dawley (8 citations) Adult female Sprague-Dawley rats (3 citations)

25 protocols using female sprague dawley rats

Inducing PCOS in Female Rats

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All procedures for animal use complied with the Guidelines for the Care and Use of Laboratory Animals, 11^thedition by the National Institutes of Health, and were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Mississippi Medical Center (#1495).
Female Sprague Dawley (SD) rats (50–75 g) at 3 weeks of age (Envigo, Indianapolis, IN) were housed and maintained throughout the study on standard chow in a room on 12/12-h light/dark cycle at 25°C and 50–60% humidity with ad libitum access to food and water. After one week of acclimatization to the vivarium, rats were implanted subcutaneously with continuous-release dihydrotestosterone (DHT) pellets (7.5 mg/90 days; daily dose of 83 μg; Innovative Research, Sarasota, Florida) or 7.5 mg placebo pellets (Innovative Research, Sarasota, Florida). The dose of DHT induces a hyperandrogenic state similar to women with PCOS [23 ]. The HAF or placebo control rats were aged to 14 −15 weeks before study and body weight was measured weekly.

, & MOULANA M. (2019). Immunophenotypic Profile of Leukocytes in Hyperandrogenemic Female Rat an Animal Model of Polycystic Ovary Syndrome. Life sciences, 220, 44-49.

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Hyperandrogenemic Female Rat Model

Cited 1 time

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Female Sprague–Dawley (SD) rats were obtained at 3 weeks of age from the vendor (Envigo, Indianapolis, IN) and allowed to equilibrate in a temperature-controlled environment with 12-h:12-h light:dark cycle for 1 week. As shown in Figure S1A and S1B, rats were randomly selected to be implanted with either 5α-dihydrotestosterone (DHT) or placebo pellets to generate hyperandrogenemic females (HAF) or controls, respectively, as we previously described ^{19 (link),22}. All protocols followed the ARRIVE Guidelines, and were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Mississippi Medical Center and complied with the Guidelines for the Care and Use of Laboratory Animals by the National Institutes of Health.

Shawky N.M., Patil C.N., Dalmasso C., Maranon R.O., Romero D.G., Drummond H, & Reckelhoff J.F. (2020). Pregnancy protects hyperandrogenemic female rats from postmenopausal hypertension.. Hypertension (Dallas, Tex. : 1979), 76(3), 943-952.

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Female Rat Euthanasia Protocol

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All experimental procedures were approved by the University of Pittsburgh Institutional Animal Care and Use Committee. Female Sprague Dawley rats (250–300 g; Envigo) were used throughout. Rats were housed under a 12/12 h light/dark cycle with free access to food and water. Animals were randomized to blinded treatment and control groups. The stage of the estrous cycle was not monitored. Animals were euthanized by CO₂ inhalation, followed by a thoracotomy.

Montalbetti N., Rued A.C., Taiclet S.N., Birder L.A., Kullmann F.A, & Carattino M.D. (2017). Urothelial Tight Junction Barrier Dysfunction Sensitizes Bladder Afferents. eNeuro, 4(3), ENEURO.0381-16.2017.

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Sprague–Dawley Rat Housing Protocol

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Female Sprague–Dawley rats were purchased from Envigo, housed on a 12/12 h light/dark cycle, and given food ad libitum. Animal experiments were approved by the Animal Care and Use Committee at the University of Virginia and conformed to the National Institutes of Health guidelines for the use of animals in research.

Mead B.P., Kim N., Miller G.W., Hodges D., Mastorakos P., Klibanov A.L., Mandell J.W., Hirsh J., Suk J.S., Hanes J, & Price R.J. (2017). Novel Focused Ultrasound Gene Therapy Approach Noninvasively Restores Dopaminergic Neuron Function in a Rat Parkinson’s Disease Model. Nano letters, 17(6), 3533-3542.

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Sprague Dawley Rat Dural Cannulation

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Female Sprague Dawley rats (200–250 g), purchased from Envigo (Indianapolis, IN), were housed in a climate-controlled room on a regular 12 h light/dark cycle with lights on at 7:00 am with food and water available ad libitum. Animals were initially housed 3 per cage but were individually housed after dural cannulation. All procedures were performed during the 12-hour light cycle according to the policies/recommendations of the International Association for the Study of Pain and the NIH guidelines for laboratory animals, and with IACUC approval from the University of Arizona.

Liktor-Busa E., Blawn K.T., Kellohen K.L., Wiese B.M., Verkhovsky V., Wahl J., Vivek A., Palomino S.M., Davis T.P., Vanderah T.W, & Largent-Milnes T.M. (2020). Functional NHE1 expression is critical to blood brain barrier integrity and sumatriptan blood to brain uptake. PLoS ONE, 15(5), e0227463.

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Sprague-Dawley Rat Study Protocol

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Female Sprague–Dawley rats (200–250 g, 8–10 weeks old) (Envigo, Milan, Italy) were used in this research. The University of Messina Review Board for animal care (OPBA) approved the study (ethical approval number: 499/2018-PR). All animal experiments agree with the new Italian regulations (D.Lgs 2014/26), EU regulations (EU Directive 2010/63) and the ARRIVE guidelines.

Cordaro M., Trovato Salinaro A., Siracusa R., D’Amico R., Impellizzeri D., Scuto M., Ontario M.L., Interdonato L., Crea R., Fusco R., Cuzzocrea S., Di Paola R, & Calabrese V. (2021). Hidrox® and Endometriosis: Biochemical Evaluation of Oxidative Stress and Pain. Antioxidants, 10(5), 720.

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Female Rat Model for Headache Disorders

Cited 2 times

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Female Sprague Dawley rats (200–250 g) were purchased from Envigo and housed in a climate-controlled room on a regular 12/12 h light/dark cycle with lights on at 7 A.M. with food and water available ad libitum in the vivarium five floors below the lab. All procedures were performed during the light phase and according to the policies and recommendations of the International Association for the Study of Pain, the National Institutes of Health (NIH) guidelines for laboratory animals, and with approval from the Institutional Animal Care and Use Committee of the University of Arizona. For Number of Animals Consistent with NIH policy (NOT-OD-15-102) on relevant biological variables (e.g., strain, sex, and age) experiments were randomized to blinded treatment (topiramate, sumatriptan, or vehicle), injury (KCl or aCSF), and control groups, giving 80% power to detect a treatment effect size of 20% compared to a baseline response of 5% at a significance level of 0.05. Numbers required to achieve statistical power for each experiment were determined by G*Power 3.1. Female rats were used as headache disorders affect females to males at a nearly 3:1 ratio (Bolay et al., 2011 (link); Stucky et al., 2011 (link); Misra et al., 2013 (link); Chai et al., 2014 (link); Faria et al., 2015 (link)).

Cottier K.E., Galloway E.A., Calabrese E.C., Tome M.E., Liktor-Busa E., Kim J., Davis T.P., Vanderah T.W, & Largent-Milnes T.M. (2018). Loss of Blood-Brain Barrier Integrity in a KCl-Induced Model of Episodic Headache Enhances CNS Drug Delivery. eNeuro, 5(4), ENEURO.0116-18.2018.

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Sprague-Dawley Rat Care Protocol

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Female Sprague–Dawley rats (Envigo, Milan, Italy) were used in this research. The University of Messina Review Board for animal care (OPBA) approved the study. All animal experiments complied with the new Italian regulations (D.Lgs 2014/26), EU regulations (EU Directive 2010/63) and the ARRIVE guidelines.

Genovese T., Siracusa R., D’Amico R., Cordaro M., Peritore A.F., Gugliandolo E., Crupi R., Trovato Salinaro A., Raffone E., Impellizzeri D., Cuzzocrea S., Fusco R, & Di Paola R. (2021). Regulation of Inflammatory and Proliferative Pathways by Fotemustine and Dexamethasone in Endometriosis. International Journal of Molecular Sciences, 22(11), 5998.

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Dihydrotestosterone Exposure in Sprague Dawley Rats

Cited 1 time

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Female Sprague Dawley rats were obtained from Envigo (Indianapolis, IN) at 3 weeks of age. Rats were maintained throughout the study on standard rat chow diet (Teklad 22/5 Rodent Diet #8640; Envigo), housed in temperature-controlled rooms with a constant light/dark cycle (12 h/12 h) and free access to food and water. At 4 weeks of age, rats were randomly assigned to be implanted subcutaneously on the back of the neck with a continuous-release DHT (7.5 mg/90 days; Innovative Research of America, Sarasota, FL) or placebo pellets (n = 10 per group), as we previously reported [29 (link)]. Pellets were replaced every 90 days. After 6 months of DHT or placebo exposure, pellets were discontinued (ex-DHT), and animals were followed for an additional 6 months and compared with control groups. At the end of the study, blood samples and tissues were collected.
All experimental protocols were performed in accordance with the NIH Guide for the Care and Use of Laboratory Animals, 8th Edition, and were reviewed and approved by the Institutional Animal Care and Use Committee of the University of Mississippi Medical Center.

Torres Fernandez E.D., Adams K.V., Syed M., Maranon R.O., Romero D.G, & Yanes Cardozo L.L. (2018). Long-Lasting Androgen-Induced Cardiometabolic Effects in Polycystic Ovary Syndrome. Journal of the Endocrine Society, 2(8), 949-964.

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Rat Models for Bladder Obstruction

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Fe Male Sprague Dawley rats (≈200 g, 40–50 days, Envigo, USA) were used for BOO studies. Female rats are the standard for BOO based on ease of surgery, lack of tortuosity and short length of the urethra. Male Sprague Dawley rats (≈350 g, 70–80 days, Envigo, USA) were used for in vitro experiments. Animal use protocols were approved by the Institutional Animal Care and Use Committees (IACUC) at either Duke University Medical Center or East Carolina University.

Lütolf R., Hughes FM J.r., Inouye B.M., Jin H., McMains J.C., Pak E.S., Hannan J.L, & Purves J.T. (2017). NLRP3 / IL-1β mediates Denervation During Bladder Outlet Obstruction in Rats. Neurourology and urodynamics, 37(3), 952-959.

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