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Topbp1 ab2402

Manufactured by Abcam
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Sourced in United Kingdom

TOPBP1 (ab2402) is a protein that plays a critical role in DNA repair and cell cycle regulation. It is an essential component of the DNA damage response pathway and is involved in the activation of the ATR kinase, which is a key sensor of DNA damage. The product is suitable for use in various research applications, including cell biology, molecular biology, and biochemistry.

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Lab products found in correlation

γh2ax, by Cell Signaling Technology (1 mentions) Caspase 8, by Cell Signaling Technology (1 mentions) Phospho plk1, by Cell Signaling Technology (1 mentions) Phospho wee1, by Cell Signaling Technology (1 mentions) Phospho brca1, by Cell Signaling Technology (1 mentions) Rad51 ab133534, by Abcam (1 mentions) Phospho cdc25c, by Cell Signaling Technology (1 mentions) Cleaved caspase 3, by Cell Signaling Technology (1 mentions) Beclin 1, by Cell Signaling Technology (1 mentions) Cleaved parp, by Cell Signaling Technology (1 mentions) Caspase 3, by Cell Signaling Technology (1 mentions) Caspase 9, by Cell Signaling Technology (1 mentions) Gapdh, by Cell Signaling Technology (1 mentions) Mcl 1, by Cell Signaling Technology (1 mentions) Bcl 2, by Cell Signaling Technology (1 mentions) E cadherin, by Cell Signaling Technology (1 mentions) Phospho cdc2, by Cell Signaling Technology (1 mentions) Phospho atr, by Cell Signaling Technology (1 mentions) Lc3a b, by Cell Signaling Technology (1 mentions) Gapdh, by Abcam (1 mentions)

Spelling variants of this product

Ab2402 (9 citations)

2 protocols using topbp1 ab2402

1

Comprehensive Cell Signaling Antibody Panel

Check if the same lab product or an alternative is used in the 5 most similar protocols
The antibodies used included cleaved-PARP (#5625), Bcl-2 (#3498), MCL-1 (#39224), caspase-8 (#9746), caspase-9 (#9502), Beclin 1 (#3738), P62 (#23214), LC3 A/B (#4108), phospho-Histono H3 (Ser10, #53348), PLK1 (#4513), phospho-PLK1 (Thr210, #9062), phospho-CDC25C (Ser216, #4901), CDC2 (#28439), phospho-CDC2 (Tyr15, #4539), WEE1 (#13084), phospho-WEE1 (Ser642, #4910), caspase-3 (#9665), cleaved caspase-3 (#9661),γH2AX (Ser139; #2577), phospho-BRCA1 (Ser1524, #9009), phospho-ATR (Ser428, #2853), E-cadherin (#14472), Ki-67 (#9027) and GAPDH (#51332), all of which were purchased from Cell Signaling Cytochrome C (ab13575), GSMDE (ab215191), CDC25C (ab32444), GSDMD (ab219800), TOPBP1 (ab2402), RAD51 (ab133534) and 53BP1 (ab36823) antibodies were purchased from Abcam (United Kingdom).
Wu M., Wang Y., Yang D., Gong Y., Rao F., Liu R., Danna Y., Li J., Fan J., Chen J., Zhang W, & Zhan Q. (2019). A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinoma. EBioMedicine, 41, 244-255.
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2

Investigating DNA Damage Response Signaling

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AR (sc-816) from Santa Cruz; c-Myb (ab109127), BRCA1 (ab16780) and TopBP1 (ab2402) from Abcam; GAPDH (#21188), ATR (#2790), P-ATR (Ser428) (#2853), Chk1 (#2360), P-Chk1 (Ser317) (#12302), P-Chk1 (Ser345) (#2348) from Cell Signaling.
Li L., Chang W., Yang G., Ren C., Park S., Karantanos T., Karanika S., Wang J., Yin J., Shah P.K., Takahiro H., Dobashi M., Zhang W., Efstathiou E., Maity S.N., Aparicio A.M., Tapia E.M., Troncoso P., Broom B., Xiao L., Lee H.S., Lee J.S., Corn P.G., Navone N, & Thompson T.C. (2014). Targeting Poly (ADP-Ribose) Polymerase and the c-Myb-TopBP1-ATR-Chk1 Signaling Pathway in Castration-Resistant Prostate Cancer. Science signaling, 7(326), ra47.
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