4 dimethylaminopyridine

Manufactured by Energy Chemical

Sourced in China

4-dimethylaminopyridine is a chemical compound commonly used as a catalyst or reagent in organic chemistry reactions. It functions as a nucleophilic catalyst, assisting in the activation and conversion of various substrates.

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4-Dimethylaminopyridine (DMAP) (4 citations)

6 protocols using 4 dimethylaminopyridine

Multifunctional Dendritic Nanosensor

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Carboxyl PEG_2k‐N₃ and Methoxyl PEG_2k carboxyl were purchased from Ponsure Biological. Sodium ascorbate, Tri[(1‐benzyl‐1H‐1,2,3‐triazol‐4‐yl) methyl] amine (TBTA), and CuI were purchased from Accela ChemBio Co., Ltd. (Shanghai, China). N‐(3‐Dimethylaminopropyl)‐N’‐ethylcarbodiimide hydrochloride (EDC), 1‐Hydroxybenzotriazole (HOBt), N‐Hydroxysuccinimide (NHS), 4‐Dimethylaminopyridine (DMAP), and N,N‐Diisopropylethylamine (DIPEA) were purchased from Energy Chemical (Shanghai, China). PAMAM 5.0 was purchased from Weihai CY Dendrimer Technology Co., Ltd. (Shandong, China). 3‐Hydroxy‐4‐nitrobenzaldehyde was purchased from Shanghai Haohong Biomedical Technology Co., Ltd. (Shanghai, China). Propargyl bromide was purchased from Macklin Biochemical Co., Ltd. 4‐Nitrophenyl chloroformate and DPBF from Sigma–Aldrich. Antifade Mounting Medium with DAPI was purchased from Beyotime Biotech. Inc. (Shanghai, China). Resiquimod (R848) was purchased from Jiangsu Aikon (Jiangsu, China). Detailed information on the antibodies such as fluorescent antibody type, manufacturer, clone, and catalog number used in this study was provided in Tables S1–S3 (Supporting Information).

Wang Y., Li G., Su J., Liu Y., Zhang X., Zhang G., Wu Z., Li J., Zhang Y., Wang X., Yang Z., Wang R., Wang C., Wang L., Sun F., Zhao W., Wang X., Peng X, & Shao K. (2024). Spatiotemporal Controllable Sono‐Nanovaccines Driven by Free‐Field Based Whole‐Body Ultrasound for Personalized Cancer Therapy. Advanced Science, 11(14), 2307920.

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Synthesis and Characterization of PTX-S-MAL Conjugate

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Paclitaxel (PTX) was obtained from Nanjing Jingzhu Reagent Co., Ltd, Nanjing, China. p-Toluenesulfonic acid, thiodiglycolic anhydride, 4-dimethylaminopyridine (DMAP), 1-hydroxybenzotriazole (HOBT), 6-maleimidocaproic acid and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDCI) were acquired from Energy Chemical Reagent Co., Ltd, Shanghai, China. Methoxy-PEG_2k-amine (NH₂-PEG) and ethylene glycol were purchased from Aladdin Co., Ltd, Shanghai, China. Dopamine-HCl and Tris–HCl were obtained from Dalian Meilun Bio-Technology Corporation. Hoechst was obtained from Vector Laboratories, Burlingame, CA. All other reagents and solvents mentioned in this article were of analytical grade. PTX-S-MAL was synthesized according to our previous method.

Yang B., Wang K., Zhang D., Ji B., Zhao D., Wang X., Zhang H., Kan Q., He Z, & Sun J. (2019). Polydopamine-modified ROS-responsive prodrug nanoplatform with enhanced stability for precise treatment of breast cancer. RSC Advances, 9(16), 9260-9269.

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Synthesis and Characterization of Drug-Loaded Nanoparticles

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Ethyl acrylate, bromoacetic acid, adenine, uracil, N,N'-diisopropylcarbodiimide (DIC), and 4-dimethylaminopyridine (DMAP) were purchased from Energy Chemical Co., LTD. (Beijing, China). 3-(4,5-Dimethyl-thiazol-2-yl)−2,5-diphenyl tetrazolium bromide (MTT), and 4′,6-diamidino-2-phenylindole dihydrochloride (DAPI) were purchased from Sigma-Aldrich Co. LTD (Shanghai, China). 1,1-Dioctadecyl-l-3,3,3,3-tetramethylindodicarbocyanine perchlorate (DiD), Nile Red and PTX were purchased from Beijing J&K Co., LTD. (Beijing, China). Other organic solvents and chemical reagents were purchased from Sinopharm Chemical Reagent Co., LTD.

Dong S., Ma S., Chen H., Tang Z., Song W, & Deng M. (2022). Nucleobase-crosslinked poly(2-oxazoline) nanoparticles as paclitaxel carriers with enhanced stability and ultra-high drug loading capacity for breast cancer therapy. Asian Journal of Pharmaceutical Sciences, 17(4), 571-582.

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Synthesis of Fluorene-Based Heterocycles

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Methyl cyanoacetate (99%; Macklin; China), malononitrile (99%; Aladdin; China), methyl methanesulfonylacetate (95%; Bidepharm; China), dimethyl malonate (99%; CIVI; China), benzothiazole-2-acetonitrile (98%; CIVI; China), phenylacetonitrile (99%; Jiudingchem; China), ethyl dimethylphosphonoacetate (95%; Energy Chemical; China), fluorene (98%; CIVI; China), benzyl dichloride (98%; Macklin; China), 1,2-bis(2-chloroethoxy)ethane (98%; Energy Chemical; China), 1,4-dibromobutane (98%; Energy Chemical; China), acrylyl chloride (98%; Aladdin; China), lithium aluminium hydride (97%; Energy Chemical; China), trimethylolpropane triacrylate (TMPTA; 99%; AlibabaSJ.com; China), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU; 98%; CIVI; China) and 4-dimethylaminopyridine (DMAP; 98%; Energy Chemical; China) were used as received. Ethylene glycol (EG; Sinopharm Chemical Reagent; China), triethylamine (TEA; Sinopharm Chemical Reagent; China) and dichloromethane (DCM; Sinopharm Chemical Reagent; China) were used after removing water using a molecular sieve. N,N-dimethylformamide (DMF) was purchased from Sinopharm Chemical Reagent and used as received. All other reagents were obtained from Shanghai Chemical Reagent and used as received.

Jiao C., Gao L., Yu B., Cong H, & Shen Y. (2019). Mild polyaddition and polyalkylation based on the carbon–carbon bond formation reaction of active methylene. RSC Advances, 9(69), 40455-40461.

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Synthesis and Cytotoxic Evaluation

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All starting materials were obtained from commercial suppliers and used as received. Methylene blue, sodium hydrosulfite and methyl iodide were purchased from J&K Chemical Technology. 4-Dimethylaminopyridine was purchased from Energy Chemical Company. Other general chemicals were purchased from Adamas-beta; Beijing InnoChem Science & Technology Co., Ltd; Aldrich Chemical Co.; Dojindo; and Sinopharm Chemical Reagent Co., Ltd. All organic solvents were supplied by Strong Chemical Company (Shanghai, China). MTT and cell culture reagents were purchased from Invitrogen.
All experiments were performed in compliance with the relevant laws and institutional guidelines. All animal experiments were performed according to procedures approved by the Fudan University Committee on Animal Care and Use. Informed consent was obtained for any experimentation with human subjects.

Wei P., Yuan W., Xue F., Zhou W., Li R., Zhang D, & Yi T. (2017). Deformylation reaction-based probe for in vivo imaging of HOCl †Electronic supplementary information (ESI) available: Movie S1 (naked-eye detection in aqueous solution); Movie S2 (in vivo NIR fluorescence imaging) and Movie S3 (Z-scan images of frozen sections isolated from the arthritic area). Crystal data for FDOCl-1 (CCDC number: 1555875; CIF); crystal data for FDOCl-4 (CCDC number: 1555871; CIF). CCDC 1555875 and 1555871. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03784h. Chemical Science, 9(2), 495-501.

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Synthesis of Chitosan/PVA Composite Films with Copper Nanoparticles

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Chitosan/poly(vinyl alcohol) composite film-supported copper nanoparticles (CP@Cu NPs) were prepared, according to the procedures reported [39 (link)]. The characterization of CP@Cu NPs was described in the supplementary materials. Bis(pinacolato)diboron (B₂(pin)₂, AR), methanol (MeOH, AR), ethanol (EtOH, AR), acetone (AR), tetrahydrofuran (THF, AR), ether (Et₂O, AR), 2,2-bipyridine (AR), 4-dimethylaminopyridine (DMAP, AR), 2-cyanopyridine (AR), 2-chloropyridine (AR), 2-bromopyridine (AR), and 4-picoline (AR) were obtained commercially from Energy Chemical (Shanghai, China).

Li B., Wen W., Wen W., Guo H., Fu C., Zhang Y, & Zhu L. (2023). Application of Chitosan/Poly(vinyl alcohol) Stabilized Copper Film Materials for the Borylation of α, β-Unsaturated Ketones, Morita-Baylis-Hillman Alcohols and Esters in Aqueous Phase. Molecules, 28(14), 5609.

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