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Anti mouse nk1.1 antibody clone pk136

Manufactured by BioXCell
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The Anti-mouse NK1.1 antibody (clone PK136) is a laboratory reagent used for the identification and isolation of natural killer cells (NK cells) in mouse samples. It binds specifically to the NK1.1 surface antigen expressed on mouse NK cells.

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Lab products found in correlation

Anti asialo gm1 antibody clone poly21460, by BioLegend (2 mentions) Anti mouse ifnγ antibody clone xmg1.2, by BioLegend (1 mentions) Anti mouse cd4 clone rm4 5, by Thermo Fisher Scientific (1 mentions)

Spelling variants of this product

Anti-NK1.1 (25 citations) Anti-NK1.1 (PK136, (23 citations) Clone PK136 (8 citations) NK1.1 (clone PK136, (6 citations) NK1.1 (PK136, (3 citations) Anti-mouse NK1.1 antibody (3 citations) Anti–NK1.1 antibody (PK136; (2 citations) Anti-NK1.1 antibody (2 citations)

3 protocols using anti mouse nk1.1 antibody clone pk136

1

In vivo depletion of NK cells and ILC1s

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In vivo, NK cells and ILC1s were depleted by i.p. injection with 200 μg/mouse anti-mouse NK1.1 antibody (clone PK136; BioXcell, USA); NK cells alone were depleted by i.p. injection with 40 μl/mouse anti-asialo-GM1 antibody (clone Poly21460; BioLegend, USA). To maintain the depletion, the same injections were given on days 7, 14, and 21.
Li Z., Ma R., Ma S., Tian L., Lu T., Zhang J., Mundy-Bosse B.L., Zhang B., Marcucci G., Caligiuri M.A, & Yu J. (2022). ILC1s Control Leukemia Stem Cell Fate and Limit Development of AML. Nature immunology, 23(5), 718-730.
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2

In vivo depletion of NK cells and ILC1s

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In vivo, NK cells and ILC1s were depleted by i.p. injection with 200 μg/mouse anti-mouse NK1.1 antibody (clone PK136; BioXcell, USA); NK cells alone were depleted by i.p. injection with 40 μl/mouse anti-asialo-GM1 antibody (clone Poly21460; BioLegend, USA). To maintain the depletion, the same injections were given on days 7, 14, and 21.
Li Z., Ma R., Ma S., Tian L., Lu T., Zhang J., Mundy-Bosse B.L., Zhang B., Marcucci G., Caligiuri M.A, & Yu J. (2022). ILC1s Control Leukemia Stem Cell Fate and Limit Development of AML. Nature immunology, 23(5), 718-730.
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3

Antibody Depletion Modulation of IFNγ

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On days 5 and 9 PI SeV, 0.1, 1, 10, or 100 µg of anti-mouse IFNγ antibody (clone XMG1.2) or control rat IgG1 antibody (BioLegend) were injected SQ. For NK1.1 depletion, anti-mouse NK1.1 antibody (clone PK136; BioXCell) or control mouse IgG2a (clone C1.18.4; BioXCell) was used, and for CD4 depletion anti-mouse CD4 (clone RM4-5; eBioscience) or control rat IgG2b (eBR2a; eBioscience) were used.
Grayson M.H., Camarda L.E., Hussain S.R., Zemple S.J., Hayward M., Lam V., Hunter D.A., Santoro J.L., Rohlfing M., Cheung D.S, & Salzman N.H. (2018). Intestinal Microbiota Disruption Reduces Regulatory T Cells and Increases Respiratory Viral Infection Mortality Through Increased IFNγ Production. Frontiers in Immunology, 9, 1587.
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