Polyethylene glycoldimethacrylate pegdma

Manufactured by Polysciences

Polyethylene glycoldimethacrylate (PEGDMA) is a synthetic chemical compound used as a crosslinking agent in various applications. It consists of a polyethylene glycol backbone with methacrylate groups at both ends. PEGDMA is commonly used in the formulation of hydrogels, polymers, and other materials for a range of scientific and industrial purposes.

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PEGDMA (10 citations)

3 protocols using polyethylene glycoldimethacrylate pegdma

Tissue-Specific Biomaterials Synthesis

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The chemicals used in
this study were obtained
from the following sources: N-(2-Hydroxyethyl)acrylamide
(HEAam) from Chemie Brunschwig AG, lithium phenyl 2,4,6-trimethylbenzoyl
phosphinate (LAP) from Sigma-Aldrich, and polyethylene glycoldimethacrylate
(PEGDMA, Mn = 20 kDa) from Polysciences. Additionally, acrylamide
(Aam)-polyethylene glycol (PEG, 1 kDa)-NHS was acquired from Abbexa.
Young male rabbit tracheas (5–6 kg) were provided by Delimpex
AG, Pfäffikon, Switzerland. Moreover, porcine skin, bovine
heart, kidney, lung, and liver samples were obtained from a local
slaughterhouse.

Uslu E., Rana V.K., Guo Y., Stampoultzis T., Gorostidi F., Sandu K, & Pioletti D.P. (2023). Enhancing Robustness of Adhesive Hydrogels through PEG-NHS Incorporation. ACS Applied Materials & Interfaces, 15(43), 50095-50105.

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Hydrogel Synthesis and Characterization

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CS (MW 100,000 to 300,000 g/mol) and acetic acid were supplied by Fisher Scientific (Acros Organics). Poly(ethylene glycol) dimethacrylate (PEGDMA) MW 200 and 600 g/mol were obtained from PolySciences Inc. Calcium chloride (CaCl₂), ammonium phosphate dibasic ((NH₄)₂HPO₄), ammonium hydroxide, sodium bicarbonate and benzophenone were purchased from Sigma-Aldrich. All materials were used as received.

Devine D.M., Hoctor E., Hayes J.S., Sheehan E, & Evans C.H. (2017). Extended release of proteins following encapsulation in hydroxyapatite/chitosan composite scaffolds for bone tissue engineering applications. Materials science & engineering. C, Materials for biological applications, 84, 281-289.

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Biomimetic Composite Scaffold for Bone Regeneration

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Medical-grade polycaprolactone (PCL, M_n = 80 kDa) was purchased from Sigma-Aldrich. β-TCP nano-powder with average particle size of 100 nm (TCP) was purchased from Berkeley Advanced Materials Inc. N,N-Dimethylformamide (DMF), sodium hydroxide (NaOH), and ethanol were purchased from Fisher Scientific Inc. N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC), N-Hydroxysulfosuccinimide (NHS), 2-(N-Morpholino)ethanesulfonic acid (MES), N-(3-Aminopropyl)methacrylamide hydrochloride (APMA), gelatin type A, and heparin, and Calcium sulfate dihydrate (CaSO₄) were purchased from Sigma-Aldrich. Polyethylene glycol dimethacrylate (PEGDMA, M_n = 1000 gr/mol) was received from Polyscience, Inc. Sodium alginate (alginate, 500 GM) was purchased from Pfaltz & Bauer Inc. Human BMP-2 protein was provided by Medtronic. Human BMP-2 ELISA kit was purchased from Sigma-Aldrich.

Lin S., Maekawa H., Moeinzadeh S., Lui E., Alizadeh H.V., Li J., Kim S., Poland M., Gadomski B.C., Easley J.T., Young J., Gardner M., Mohler D., Maloney W.J, & Yang Y.P. (2023). An osteoinductive and biodegradable intramedullary implant accelerates bone healing and mitigates complications of bone transport in male rats. Nature Communications, 14, 4455.

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