Ge lunar

Manufactured by GE Healthcare

Sourced in United Kingdom, United States

The GE Lunar is a line of medical imaging equipment designed for diagnostic purposes. It utilizes advanced technology to capture detailed images of the body's internal structures, providing healthcare professionals with valuable data for clinical analysis and decision-making.

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Lab products found in correlation

Sliceomatic image analysis software, by Tomovision (2 mentions) Luminex 200 analyzer, by Merck Group (1 mentions) Acheiva, by Philips (1 mentions) Torbutrol, by Zoetis (1 mentions) Dexdormitor, by Zoetis (1 mentions) Densitometer, by Hologic (1 mentions) Ge lunar prodigy, by GE Healthcare (1 mentions) Discovery w, by Hologic (1 mentions) In body 720 body composition analyser, by Biospace (1 mentions)

16 protocols using ge lunar

DXA Scans for Osteoporosis Evaluation

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DXA scans of the hip and spine were acquired on Hologic or GE Lunar scanners at 16 clinics using 15 scanners. Scans were reviewed for quality and analyzed centrally at the University of California San Francisco (UCSF) using Hologic v13.4 or GE Lunar v14.0 software. Local DXA operators were certified by UCSF. A local spine phantom was scanned regularly throughout the study on each scanner; all scanners were within acceptable limits. GE Lunar BMD values were standardized to Hologic values using published equations for hip and spine [9 (link), 10 (link)]. BMD T-scores were calculated using values for young female Caucasians as the reference [11 (link)]. Osteoporosis was defined based on femoral neck BMD as T-score ≤−2.5 and low bone density (osteopenia) as −2.5

Kern V.D., Smith J.D., Schwuchow J.M, & Sack F.D. (2001). Amyloplasts That Sediment in Protonemata of the Moss Ceratodon purpureus Are Nonrandomly Distributed in Microgravity. Plant Physiology, 125(4), 2085-2094.

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Body Composition Assessment Protocol

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Weight and height were measured pre- and post- intervention and BMI was calculated. Waist circumference was measured using the Gulick II tape measure directly on the skin. Fat mass (FM; kg) and fat-free mass (FFM; kg) were determined by dual-energy X-ray absorptiometry (DXA) using a GE Lunar (GE Healthcare, UK). Skeletal muscle index was calculated as appendicular lean mass normalized by the square height.

Serrano J., Boyd J., Mason C., Smith K.R., Karolyi K., Kondo S., Brown I.S., Maurya S.K., Meshram N.N., Serna V., Gilger J., Branch D.A., Gardell S.J., Baskin K.K., Ayala J.E., Pratley R.E., Goodpaster B.H., Coen P.M, & Kyriazis G.A. (2023). The TAS1R2 sweet taste receptor regulates skeletal muscle mass and fitness. Research Square.

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Thyroid Function and Bone Density

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Subject height and weight were measured at each BMD examination. Body mass index (BMI) was calculated as weight in kg divided by the square of height in meters. Basal serum FT4, T3 and TSH levels were assessed with an Advia Centaur Immunodiagnostic system (Siemens Healthcare Diagnostics, Tarrytown, NY, USA). The reference ranges were 0.89–1.76 ng/dL for fT4, 76–190 ng/dL for T3 and 0.55–4.78 mIU/L for TSH. TRAb levels were measured by radio-receptor assay (TSH Rezak; Medipan Diagnostica, Germany; normal values <15%). BMD was measured with dual X-ray absorptiometry (GE Lunar^®) in the lumbar spine (LS) and femur. For lumbar spine BMD, when the specific vertebrae were not suitable for analysis due to degenerative changes or any other reasons, BMD was calculated excluding the affected vertebrae. Our center's coefficient of variation for BMD is 0.937% in the LS. All DXA scans were analyzed, and TBS was calculated using TBS insight^® software (version 2.1) with DXA images on the same vertebrae as in the BMD measurements. The coefficient of variation for TBS measurement is 1.408% in the LS at our center. This study was approved by Institutional Review Board of Ajou University Hospital (IRB No. AJIRB-MED-MDB-14-247). And we retrospectively reviewed patient medical records, thus Institutional Review Board agreed waiver of requirement of informed consent for this study.

Ock S.Y., Chung Y.S, & Choi Y.J. (2016). Changes in bone mineral density and trabecular bone score in Graves' disease patients after anti-thyroid therapy. Osteoporosis and Sarcopenia, 2(3), 175-179.

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Longitudinal Bone Density and Biomarkers

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BMD was assessed at screening, month 6 and month 12 via dual-energy X-ray absorptiometry (DXA), using a Hologic (Hologic Corporation) or GE Lunar (GE Medical Systems) densitometer at study sites. The percent change from baseline in lumbar spine, total hip, femoral neck, and trochanter BMD was calculated. Lateral spine X-ray of T4-L5 (one thoracic and one lumbar X-ray) was performed at screening, month 6 and month 12. Biochemical markers of bone turnover, P1NP, and s-CTx were measured at day 1, month 6, and month 12 using P1NP immunoassay and s-CTx electrochemiluminescent immunoassay (Roche Cobas E601 platform using Roche reagents), and assessed at a central laboratory (Quest Diagnostics, Shanghai, China). A constrained longitudinal data analysis (cLDA) method was used to analyze these biochemical markers.
Serum 25(OH)D levels were assessed using liquid chromatography-tandem mass spectrometry (LCMSMS; API4000 platform) at a central laboratory (Quest Diagnostics, Shanghai, China) and monitored throughout the study. The total of both 25(OH)D₃ and 25(OH)D₂ was reported as 25(OH)D.

Zhang Z.L., Liao E.Y., Xia W.B., Lin H., Cheng Q., Wang L., Hao Y.Q., Chen D.C., Tang H., De Peng Y., You L., He L., Hu Z.H., Song C.L., Wei F., Wang J., Zhang L, & Santora A.C. (2015). Alendronate sodium/vitamin D3 combination tablet versus calcitriol for osteoporosis in Chinese postmenopausal women: a 6-month, randomized, open-label, active-comparator-controlled study with a 6-month extension. Osteoporosis International, 26, 2365-2374.

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Body Composition and Metabolic Markers in Clinical Trial

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Whole body dual energy X-ray absorptiometry (DXA) scans using either Hologic (Hologic Inc., Bedford, Massachusetts, USA) or GE Lunar (GE Healthcare Lunar, Madison, Wisconsin, USA) devices were performed at baseline, weeks 48 and 96. Total limb fat (upper plus lower extremities fat), trunk fat, total body lean mass and total body fat mass were quantified using standardized scanning protocols and locally calibrated based on each manufacturer’s specifications. Technicians -blinded to study clinical information- were instructed to use the same device on the same patient during the trial without central reading.
Adipokines and markers of inflammation were performed in the department of Laboratory Medicine at Hospital Universitario La Paz, Madrid on batched serum samples stored at -80°C from weeks 0 and 48. The following markers were analysed: IL-6; IL-1β; TNF-α, Insulin, Leptin, Adiponectin and Fibroblast Growth Factor-23 (FGF-23) with a multiplex magnetic bead panel assay (HBNMAG-51 Merck Millipore) using a Luminex 200 analyzer.

Bernardino J.I., Mocroft A., Wallet C., de Wit S., Katlama C., Reiss P., Mallon P.W., Richert L., Molina J.M., Knobel H., Morlat P., Babiker A., Pozniac A., Raffi F, & Arribas J.R. (2019). Body composition and adipokines changes after initial treatment with darunavir-ritonavir plus either raltegravir or tenofovir disoproxil fumarate-emtricitabine: A substudy of the NEAT001/ANRS143 randomised trial. PLoS ONE, 14(1), e0209911.

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Bone Mineral Density Measurement

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Body weight, height, and bone mineral density (BMD) were measured. Baseline lumbar spine and hip BMD were measured using a dual energy X-ray absorptiometry (DXA) instrument (GE-Lunar, iDAX, Madison, WL, USA) installed at Keelung Chang Gung Memorial Hospital.

Chen F.P., Fu T.S., Lin Y.C, & Fan C.M. (2018). Risk factors and quality of life for the occurrence of hip fracture in postmenopausal women. Biomedical Journal, 41(3), 202-208.

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Preoperative Bone Density Assessment

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Dual Energy X-ray Absorptiometry (DXA) determined BMD T scores of the lumbar spine, femoral neck, total hip and one-third radius were obtained preoperatively using Hologic (Hologic Inc., Bedford, MA) or GE-Lunar (Lunar, GE Medical Systems, Madison, WI) densitometers, either within the Duke University Health System (DUHS) or by referring providers. The number of patients who had preoperative DXA studies performed at our institution versus an outside provider were equivalent. DXA scans performed at Duke were analyzed according to ISCD criteria to exclude vertebrae that were inappropriate for analysis due to artefactual changes. Outside DXA scan images were analyzed when available to exclude scans with excessive vertebral artefactual changes. BMD T scores were based on young normal reference ranges (manufacturer-specific or National Health and Nutrition Examination Survey-based normative data). Where available, DXA images were reviewed to ensure accurate analysis. Lowest T score site was identified for the primary analysis, based on established guidelines on diagnostic assignment of osteoporosis [17 ].

Weber T.J., Koh J., Thomas S.M., Hogue J.A., Scheri R.P., Roman S.A, & Sosa J.A. (2017). Impaired calcium sensing distinguishes primary hyperparathyroidism (PHPT) patients with low bone mineral density. Metabolism: clinical and experimental, 74, 22-31.

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Comprehensive Body Composition Assessment

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Weight and height were measured at pre-surgery, pre and post intervention, and BMI was calculated. FM and FFM were determined by dual-energy X-ray absorptiometry (DXA) using a GE Lunar (GE Healthcare, UK).
Additionally, a single-slice computed tomography (CT) protocol was carried out at L4-L5 and mid-thigh in order to assess TAAT (total abdominal adipose tissue), VAT (visceral adipose tissue), SAT (abdominal subcutaneous adipose tissue) SF+IMAT (subfascial and intramuscular adipose tissue), deep AAT and thigh skeletal muscle mass (SMM). SliceOmatic image analysis software was used to quantify all tissues (Tomo Vision, Montreal, CA).

Carnero E.A., Dubis G.S., Hames K.C., Jakicic J.M., Houmard J.A., Coen P.M, & Goodpaster B.H. (2017). Randomized Trial Reveals that Physical Activity and Energy Expenditure are associated with Weight and Body Composition after RYGB. Obesity (Silver Spring, Md.), 25(7), 1206-1216.

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Evaluating Risk Factors for Adjacent Segment Degeneration

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In line with the previous reports, potential risk factors for ASD development we have selected and evaluated, including age, gender, smoking history, diabetes mellitus, hypertension, BMI, BMD, operation time, postoperative blood loss, preoperative adjacent disc degeneration, preoperative adjacent disc height, etc. [13 (link), 14 (link)]. The T score obtained from the lumbar Dual Energy X-ray Absortiometry (DEXA, GE Lunar; Prodigy, Madison, WI) scans were used to assess the association between preoperative overall fracture risk and BMD before surgery. Preoperative adjacent disc degeneration was evaluated at the instance of the classification of Pfirrmann (I–V) depend on MRI of patients [15 ]. Patients were divided into ASD group and N-ASD group according to the presence or absence of ASD at the last follow-up.
Imaging data were collected and analysed at the imaging department of our hospital. Demographic information was retrieved from our hospital’s data base of follow-up findings.

Yuan C., Zhou J., Wang L, & Deng Z. (2022). Adjacent segment disease after minimally invasive transforaminal lumbar interbody fusion for degenerative lumbar diseases: incidence and risk factors. BMC Musculoskeletal Disorders, 23, 982.

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Multimodal Body Composition Assessment

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Weight and height were measured pre- and post- intervention, and BMI was calculated. Waist circumference was measured using the Gulick II tape measure directly on the skin. Fat mass and fat-free mass were determined by dual-energy X-ray absorptiometry (DXA) using a GE Lunar (GE Healthcare, UK).
Additionally, abdominal and thigh adipose tissue (AT) and muscle volume was measured by MRI at baseline and following treatment on a 3 Tesla magnet (Philips Acheiva) at AH TRI. The MRI scan was performed at the mid-point of the femur to quantify thigh muscle cross-sectional area, subcutaneous, and intermuscular AT (IMAT). For abdominal AT images, high resolution axial images were taken of the entire abdomen to quantify abdominal subcutaneous and visceral AT volume. Resultant images were analyzed using Analyze 11.0 (Biomedical Imaging Resource, Mayo Clinic, Rochester, MN) to segment AT and muscle depots and measure volume.

Brennan A.M., Standley R.A., Yi F., Carnero E.A., Sparks L.M, & Goodpaster B.H. (2020). Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults. Frontiers in Endocrinology, 11, 632.

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