18F-FDG PET/CT scans were obtained prior to start the combined immunotherapy and chemotherapy treatment within 3 months. PET/CT images were acquired by a dedicated scanner (GEMINI TF Big Bore; Philips Healthcare) in the Department of Nuclear Medicine and PET-CT Centre. All subjects were advised to fast for at least 6 h and have serum glucose levels of less than 11 mol/l before receiving 370 MBq (10 mCi) of FDG administered intravenously. After resting in a lounge chair for at least 1 h, the patients went through 5 min whole-body Emission scanning from the head to the thighs. During PET scanning, all subjects were asked to slow and shallow breath. The reconstructed images were obtained by ordered-subset expectation maximization (OSEM) after transmission data from CT were attenuation corrected. Thereafter, the attenuation-corrected images of PET and CT, as well as fused PET/CT images in the transverse, coronal, and sagittal planes were observed on a dedicated workstation (Xeleris; GE Healthcare).
Gemini tf big bore
Manufactured by Philips
Sourced in United States
The GEMINI TF Big Bore is a laboratory equipment product from Philips. It is designed for high-performance imaging and analysis applications. The core function of the GEMINI TF Big Bore is to provide a large bore size for enhanced imaging capabilities.
Automatically generated - may contain errors
Lab products found in correlation
Xeleris workstation, by GE Healthcare (3 mentions)
Hermes hybrid viewer, by Hermes Medical Solutions (3 mentions)
Xeleris, by GE Healthcare (2 mentions)
Vereos pet ct scanner, by Philips (1 mentions)
Brilliance bores ct, by Philips (1 mentions)
Gemini tf 16, by Philips (1 mentions)
Gemini tf, by Philips (1 mentions)
22 protocols using gemini tf big bore
1
PET/CT Imaging of Immunotherapy Response
2
Non-invasive PET-CT Imaging of RGD Peptide
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
A lyophilized kit for labeling the PRGD2 peptide (Jiangsu Institute of Nuclear Medicine) was used according to the previously published protocol (18 (link)). No fasting or specific CT contrast agents were needed. PET scans were performed 60 min after intravenous injection of 18F-RGD at approximately 1.89±0.37 MBq/kg. The PET scans were acquired on a combined PET/CT scanner (GEMINI TF Big Bore; Philips Healthcare) for 5 min per field of view. A low-dose CT scan for attenuation-correction and localization purposes was also acquired. The patients were advised to remain motionless and to breathe shallowly during the examination.
3
Multimodal Imaging of 18F-FDG Uptake
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All images were acquired using a combined PET/CT scanner (GEMINI TF Big Bore, Philips). Patients fasted for at least six hours prior to the scan but were excluded if they had a capillary glucose ≥ 200 mg/dl. Image acquisition started one hour after administration of 3.75 MBq/kg 18F-FDG. After determination of the imaging field a low-dose CT of ±30 seconds (80–175 mAs, 120 kV), which ranged from the mid thighs to the base of the skull, was performed. The obtained CT images were reconstructed onto a 512–512 matrix. After the CT-scan, a PET-scan of 15 to 20 minutes which covers the same axial field, was performed. The emission time per bed position ranged from 1 to 2 minutes, depending on the body mass index (BMI) of the patient.
4
PSMA-1007 PET/CT Imaging Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Center 1, Freiburg: [18F] PSMA-1007 had been synthesized according to Cardinale et al. (11 (link)). The patients underwent a whole-body PET scan starting 2 h after injection (median activity in megaBecquerel: 313 MBq, range: 245–454 MBq). The scans were performed with a 64-slice Vereos PET/CT scanner in 61 patients and with a Gemini TF Big Bore in 23 patients (Philips Healthcare, USA). During the PET scan, a contrast-enhanced diagnostic CT scan (120 kVp, 100–400 mAs, dose modulation) was performed. The tracer uptake was quantified using standardized uptake values (SUV) normalized body weight.
5
Renal Cortex and Muscle SUV Measurement
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
PET/CT was performed using cross-calibrated Philips GEMINI TF Big Bore or TF 16 PET/CT systems (Philips Medical Systems, Cleveland, OH). Low-dose helical CT (5-mm slice thickness, 120-kV tube voltage, and 40-mAs tube current–time product) was followed by a PET emission scanning with 2 bed positions each lasting 240 seconds. Image reconstruction involved iterative list mode time-of-flight algorithms. Corrections for attenuation, dead time, random, and scatter events were applied.
Mean standard uptake value (SUVmean) of kidney cortex was measured by 2 observers (board-certified physicians in nuclear medicine with 9 and 5 year-experience in 18F-FDG PET/CT imaging) in 4 VOI of 1 mL distributed in the upper (n = 2) and lower (n = 2) poles at distance of the pelvicalyceal zone. There was no a priori minimal threshold of distance to draw the VOI from the urinary pelvis. One VOI of 20 mL was drawn in the psoas muscle. The observer 1 repeated SUV assessment in the uppermost VOI, blinded to the initial results. SUVmean of each VOI was calculated with the following formula: [Voxel Value (Bq/mL) × Patient Weight (kg)]/[Injected Dose (Bq) × 1000 (g/kg)]. On average, it takes ~5 minutes to measure the SUVmean of the renal cortex and the psoas muscle per patient.
Mean standard uptake value (SUVmean) of kidney cortex was measured by 2 observers (board-certified physicians in nuclear medicine with 9 and 5 year-experience in 18F-FDG PET/CT imaging) in 4 VOI of 1 mL distributed in the upper (n = 2) and lower (n = 2) poles at distance of the pelvicalyceal zone. There was no a priori minimal threshold of distance to draw the VOI from the urinary pelvis. One VOI of 20 mL was drawn in the psoas muscle. The observer 1 repeated SUV assessment in the uppermost VOI, blinded to the initial results. SUVmean of each VOI was calculated with the following formula: [Voxel Value (Bq/mL) × Patient Weight (kg)]/[Injected Dose (Bq) × 1000 (g/kg)]. On average, it takes ~5 minutes to measure the SUVmean of the renal cortex and the psoas muscle per patient.
6
FDG PET/CT Imaging Protocol for Cancer Patients
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
In the Department of Nuclear Medicine and PET-CT Centre, all patients had to have serum glucose levels less than 11 mol/L and at least 6 h of fasting before intravenous administration of 370 MBq (10 mCi) of FDG. After resting in a lounge chair for a minimum of 60 min, all patients underwent 5 min whole-body emission scanning from the skull base to the upper femur. PET images were obtained with a dedicated PET/CT scanner (GEMINI TF Big Bore; Philips Healthcare). Under 4.25 mm/slice axial sampling thickness and 0.8 s rotation speed per rotation, spiral CT was performed.
All subjects were asked to maintain tidal breathing during PET scanning. The images were reconstructed by ordered-subset expectation maximization (OSEM) after attenuation correction. Then, the corresponding PET and CT images, as well as fused PET/CT images, were observed on a dedicated workstation (Xeleris; GE Healthcare) in the transverse, coronal, and sagittal planes. [18F]F-FDG PET/CT scans for all patients were performed before they received the combined treatment.
All subjects were asked to maintain tidal breathing during PET scanning. The images were reconstructed by ordered-subset expectation maximization (OSEM) after attenuation correction. Then, the corresponding PET and CT images, as well as fused PET/CT images, were observed on a dedicated workstation (Xeleris; GE Healthcare) in the transverse, coronal, and sagittal planes. [18F]F-FDG PET/CT scans for all patients were performed before they received the combined treatment.
7
Multimodal Imaging Protocol for Thoracic Oncology
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
All patients were immobilized using a thermoplastic mask in the supine position. For each patient, an axial enhanced 3DCT scan of the thoracic region was performed followed by an enhanced 4DCT scan using a 16-slice CT scanner (Philips Brilliance Bores CT, Koninklijke Philips N.V., Eindhoven, Netherlands). Subsequently, for each patient, an 18F-FDG PET-CT scan was performed using an integrated PET-CT scanner (Philips Gemini TF Big Bore) as described [12 (link)], with the patient placed in an identical simulation position as for the 3DCT and 4DCT scans.
8
PET-CT Imaging of FAPI-04 Tracer Uptake
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
Fasting and blood glucose measurements were not required or requested before imaging examinations. Patients received an intravenous injection of 4.81 MBq/kg (0.12 mCi/kg) [18F]AlF-NOTA-FAPI-04 and then rested for approximately 60 min. Scanning was then performed with an integrated in-line PET/CT system (GEMINI TF Big Bore; Philips Healthcare, Cleveland, OH, USA). Whole-body CT scans were acquired for attenuation correction using a low-dose protocol (300 mAs, 120 kV, a 512 × 512 matrix, rotation time of 1.0 s, and pitch index of 0.688; reconstructed with a soft-tissue kernel to a slice thickness of 2 mm). Subsequently, PET data were acquired in 3-dimensional mode with a 200 × 200 matrix with 1-min imaging time per bed position. After randoms, decay, and scatter correction, the data were reconstructed (Body-ctac-SB. Lstcln, Biograph 3D iterative reconstruction software, TOF correction). The patients continued normal shallow respiration during image acquisition.
9
Integrated PET/CT Imaging Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
On the same day as the 4DCT scan, the 18F-FDG-PET/CT scans of the chest were performed with an integrated PET/CT scanner (Philips Gemini TF Big Bore). Using the same immobilization devices, the patient was positioned identical to that for the 4DCT scan. Two radiation therapists were present to ensure the accuracy of the setup, assessed using a laser localizer and skin marks. All patients fasted for at least 6 hours before the PET/CT examination. All patients were injected with 7.4 MBq/kg body weight of 18F-FDG and then rested for approximately 1 hour in a quiet room before imaging. The 16-slice CT component was operated with an X-ray tube voltage peak of 120 kV, 90 mA, a slice thickness of 5 mm, and an interval of 4 mm and was used both for attenuation correction of PET data and for localization of 18F-FDG uptake in PET images. No CT contrast agent was administered. PET scanning was performed covering the same axial range for 2 minutes per bed position (total of 3–5 bed positions). Both PET and CT acquisition was performed during FB. Data were reconstructed using an ordered subset expectation maximization algorithm and attenuation correction derived from CT data. Then, the PET/CT images were transferred to MIM software (Cleveland, OH, USA).
10
Standardized [68Ga]Ga-PSMA-11 PET/CT Imaging Protocol
Check if the same lab product or an alternative is used in the 5 most similar protocols
+ Expand
[68Ga]Ga-PSMA-11 radiolabelling method is detailed in supplementary material [15 (link)]. A mean activity of [68Ga]Ga-PSMA-11 of 154 MBq (range, 124–170 MBq) was injected intravenously. Whole-body images from vertex to upper thigh with both arms elevated above the head if possible were acquired after a median interval of 64 min (range, 44–91 min) post-injection in a GEMINI TF Big Bore or a GEMINI TF 16 (Philips Medical Systems, Cleveland, OH, USA). A very low-dose CT (3-mm slice thickness; tube voltage 120 kV and tube current-time product 25 mAs) was performed for attenuation correction, followed by a PET emission scan of 60 to 120 s per bed position depending on the patient’s body mass index (bed overlap of 50%).
Lastly, a CT of the chest, abdomen and pelvis (1-mm slice thickness; tube voltage 120 kV and tube current-time product 150 to 250 mAs depending on the patient’s body mass index) was performed without injection of intravenous contrast agent. All patients received diluted oral contrast (3 g of Telebrix). PET images were reconstructed with standard 4 × 4 × 4 mm3 voxels using iterative list mode time-of-flight algorithm, and corrections for attenuation, dead-time, random and scatter events were applied.
Lastly, a CT of the chest, abdomen and pelvis (1-mm slice thickness; tube voltage 120 kV and tube current-time product 150 to 250 mAs depending on the patient’s body mass index) was performed without injection of intravenous contrast agent. All patients received diluted oral contrast (3 g of Telebrix). PET images were reconstructed with standard 4 × 4 × 4 mm3 voxels using iterative list mode time-of-flight algorithm, and corrections for attenuation, dead-time, random and scatter events were applied.
About PubCompare
Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.
We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.
However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.
Ready to get started?
Sign up for free.
Registration takes 20 seconds.
Available from any computer
No download required
Revolutionizing how scientists
search and build protocols!