For radiotherapy planning, CT was performed at slice thicknesses of 3 or 5 mm using a CT scanner (Hi-Speed Dxi; GE Healthcare, Buckinghamshire , UK) (Aquilion LB; TOSHIBA Medical Systems, Tochigi, JP). The clinical target volume (CTV) was contoured on the individual axial CT slices from each patient. The overall CTV included both the primary CTV and nodal CTV, including the pelvic and para-aortic lymph nodes. The pelvic lymph nodes were delineated on the planning CT in accordance with the Japan Clinical Oncology Group Gynecologic Cancer Study Group (JCOG-GCSG) consensus guidelines for the delineation of CTV for pelvic lymph nodes [13 (link)]. The CTV in the para-aortic region was contoured as the region between the psoas muscles, superiorly above the level of the renal artery (to the level of median T12/L1), and anteriorly encompassed the aorta and inferior vena cava with at least a 0.7-cm margin. The CTV was isotropically expanded by 7 mm to create the planning target volume (PTV). In addition, organs at risk (OARs), including the small bowel (contoured as a peritoneal space), rectum, bladder (both contoured as a whole organ), both kidneys, and spinal cord were delineated according to normal tissue contouring guidelines [14 (link),15 (link)]. No margin was added to the contoured OAR.
Hi speed dxi
Manufactured by GE Healthcare
Sourced in United Kingdom
The Hi-Speed Dxi is a laboratory equipment designed for high-speed DNA extraction. It utilizes a proprietary technology to efficiently and reliably extract DNA from a variety of sample types. The core function of the Hi-Speed Dxi is to provide a streamlined and automated DNA extraction process to support various research and diagnostic applications.
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4 protocols using hi speed dxi
1
Radiotherapy Planning and Contouring Protocol
2
Post-Brachytherapy Prostate Imaging Protocol
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Computed tomography data were acquired 4 weeks after permanent prostate brachytherapy for the dosimetric analysis according to the recommended schedule [21 (link)]. Post-implant CT was performed using a spiral CT (Hi-Speed Dxi; GE Healthcare, Buckinghamshire, UK). Computed tomography scanning was performed in patients in the supine position with a urinary catheter (8 Fr, 2.7 mm) in place, and a field of view (FOV) of 50 mm and the same pitch of 2 mm/2 mm = 1 (defined as the table feed/total detector width of the collimated beam). The urinary catheter was withdrawn with great care after the first scan to prevent perturbing the patient, and a second scan was successively performed in the same position without the catheter in place and using the same FOV. No intravenous contrast material was used.
3
Prostate Brachytherapy Imaging Protocol
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Four weeks after prostate brachytherapy, CT and MRI data were acquired for dosimetric analysis according to the recommended schedule [14 (link)]. Three imaging sequences were obtained: fat-suppressed T1-weighted imaging (FST1-WI), T2-weighted imaging (T2-WI), and T2*-weighted imaging (T2*-WI) using a Siemens Avanto 1.5T MRI scanner (Siemens, Munich, Germany) with 3 mm-thick-slices. The technical parameters of FST1-WI were as follows: repetition time (TR)/echo time (TE) in ms, 955/150; in-plane resolution, 1.0 × 0.7 mm2. The technical parameters of T2-WI were: TR/TE, 5000/100; in-plane resolution, 1.0 × 0.7 mm2; Turbo Spin Echo factor, 15. The technical parameters of T2*-WI were: TR/TE, 600/19; in-plane resolution, 1.1 × 0.7 mm2. FST1-WI, T2-WI, and T2*-WI were obtained successively. During PID, the prostate is contoured using T2-WI to estimate prostate volume.
Within 1 h of MRI, a post-implant CT was performed using a GE spiral CT (Hi-Speed Dxi; GE Healthcare, Buckinghamshire, UK). During the CT scan, a urinary catheter (8 Fr) was inserted. Sequences of 2 mm slices were acquired using a 50 mm field of view (FOV), and a pitch of 2 mm/2 mm = 1 (defined as the table feed/total detector width of the collimated beam). No intravenous contrast material was used during the CT or MRI scans.
Within 1 h of MRI, a post-implant CT was performed using a GE spiral CT (Hi-Speed Dxi; GE Healthcare, Buckinghamshire, UK). During the CT scan, a urinary catheter (8 Fr) was inserted. Sequences of 2 mm slices were acquired using a 50 mm field of view (FOV), and a pitch of 2 mm/2 mm = 1 (defined as the table feed/total detector width of the collimated beam). No intravenous contrast material was used during the CT or MRI scans.
4
Low-dose CT Scanning for Longitudinal Lung Imaging
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The CT scans were obtained through the use of 2 dedicated mobile scanners (93%) or, beginning in 2012, at 2 imaging facilities in Las Vegas and Idaho Falls (7%).
From 2000 to 2006, a coach-mounted, single-slice General Electric HiSpeed DX/I (GE Medical Systems, Milwaukee, WI) was used to obtain full-chest, helical CT scans with a low-dose technique (120 kilovolt peak [kVp], 40-50 milliamps, pitch of 1.5, 7-millimeter collimation). From 2006 to 2013, we performed CT scanning with Siemens Emotion 16, 16-slice scanners (Siemens, Malvern, PA) at most program sites, supplemented by a Siemens Sensation 64 scanner in Las Vegas and a General Electric Lightspeed 16-slice scanner in Idaho Falls in 2012. We selected kilovolt peak, tube current, pitch, and other scanner parameters to produce a CT dose index for a standard-sized patient, which was within the guidelines for low-dose chest CT scan (1.5-2.3 mGy). The average estimated effective dose across all scanners was 1 millisieverts (range = 0.8-1.2 mSv).
Of 16 229 scans, 90% (14 674) were interpreted by a single senior academic thoracic radiologist (J. M.), and the remaining scans were read by experienced radiologists in DOE communities.
From 2000 to 2006, a coach-mounted, single-slice General Electric HiSpeed DX/I (GE Medical Systems, Milwaukee, WI) was used to obtain full-chest, helical CT scans with a low-dose technique (120 kilovolt peak [kVp], 40-50 milliamps, pitch of 1.5, 7-millimeter collimation). From 2006 to 2013, we performed CT scanning with Siemens Emotion 16, 16-slice scanners (Siemens, Malvern, PA) at most program sites, supplemented by a Siemens Sensation 64 scanner in Las Vegas and a General Electric Lightspeed 16-slice scanner in Idaho Falls in 2012. We selected kilovolt peak, tube current, pitch, and other scanner parameters to produce a CT dose index for a standard-sized patient, which was within the guidelines for low-dose chest CT scan (1.5-2.3 mGy). The average estimated effective dose across all scanners was 1 millisieverts (range = 0.8-1.2 mSv).
Of 16 229 scans, 90% (14 674) were interpreted by a single senior academic thoracic radiologist (J. M.), and the remaining scans were read by experienced radiologists in DOE communities.
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