Acheiva

Manufactured by Philips

Sourced in United States, United Kingdom

The Acheiva is a high-performance laboratory equipment designed to meet the demands of modern research and analysis. It is a versatile instrument that offers precise and reliable results. The core function of the Acheiva is to facilitate efficient and accurate measurements across a wide range of applications. Detailed specifications and intended use cases are not available at this time.

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Acheiva MRI scanner (2 citations)

11 protocols using acheiva

Multimodal Brain MRI Protocol for Tumor Characterization

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MRI was performed at 1.5 or 3.0 T (Philips Acheiva) using an 8-channel head coil with a standard protocol using two doses of a gadolinium based contrast agent (GBCA) for dynamic imaging according to the following schedule: (1) Pre-contrast: Sagittal SE T1w, 3D SWI. Axial SE T1, FSE T2, EPI diffusion tensor (15 direction B = 0, 1000). (2) For dynamic contrast enhanced (DCE) MRI Dynamic 1: Dynamic contrast enhanced (DCE) MRI using T1 FFE. (3) Post-contrast 1: Axial SE T1 (follows first dose). (4) Dynamic 2: Dynamic susceptibility contrast (DSC) using T2* EPI (5) Post-contrast 2: Sagittal 3D isotropic T1-FFE and 3D FLAIR. Each dynamic study was associated with bolus injection of 0.1 mmol/kg ProHance (unless contraindicated due to prior adverse reaction in which case another agent was substituted). For DCE, injection was 0.3 mL/s. For DSC, injection rate was typically 5 mL/s, but could be reduced based on status of I.V. access.
Perfusion maps of CBV, CBF and mTT were computed by the estimation of an arterial input function and deconvolution. The preinjection for the DCE MRI component of the imaging minimizes leakage effects on DSC estimates, therefore, no leakage correction was performed.

Rowe L.S., Butman J.A., Mackey M., Shih J.H., Cooley-Zgela T., Ning H., Gilbert M.R., Smart D.K., Camphausen K, & Krauze A.V. (2018). Differentiating pseudoprogression from true progression: analysis of radiographic, biologic, and clinical clues in GBM. Journal of neuro-oncology, 139(1), 145-152.

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Quantifying Lesion Volume via Imaging

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The morphological lesion volume (expressed in ml) was measured in MRI data if available (seven patients) or in contrast-enhanced CT (CECT) data (eight patients) by manual delineation using ROVER software. CECT or MRI was performed within 8 weeks of the FDG-PET/CT examination (median, 1 day; IQR, 0 to 14 days; range, 0 to 48 days). CECT data were acquired 70 s after intravenous injection of 80 to 150 ml of a non-ionic iodinated contrast agent (Imeron 300, iomeprol 300, Bracco ALTANA Pharma GmbH, Konstanz, Germany). CT scans were performed from the apex of the lungs to the thigh (automatic tube current modulation with maximum tube current, 230 mAs; tube voltage, 120 kV; gantry rotation, 0.5 s). MRI of the liver was performed using a 1.5-T Philips Acheiva® (Philips, Best, The Netherlands) in enhanced T1 High Resolution Isotropic Volume Excitation (eTHRIVE) mode after intravenous administration of 0.025 mmol/kg bodyweight Gd-EOB-DTPA (Primovist®, Bayer, Leverkusen, Germany).

Rogasch J.M., Steffen I.G., Hofheinz F., Großer O.S., Furth C., Mohnike K., Hass P., Walke M., Apostolova I, & Amthauer H. (2015). The association of tumor-to-background ratios and SUVmax deviations related to point spread function and time-of-flight F18-FDG-PET/CT reconstruction in colorectal liver metastases. EJNMMI Research, 5, 31.

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3D MRI-based Renal Volume Quantification

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Data were collected using a 3 T whole-body MR scanner (Philips Acheiva, Philips Medical Systems Lts, NL). Following acquisition of scout images a 3D imaging volume was acquired using a T1-weighted spoiled gradient echo acquisition in the oblique-coronal plane. The volume encompassed both kidneys and the descending aorta and the data were obtained in a single breathhold. Gadolinium was not used for acquisition of the data. The following parameters were used for the acquistion: TR = 4.0ms, TE = 1.0ms, FOV = 400x400x80mm, flip angle = 14 degrees, 2 signal averages, parallel acquisition using a SENSE factor = 2, following interpolation in the Fourier domain matrix = 256x256x40). The parenchymal volumes were calculated from the 3D volume images using the voxel-count method as we have previously described[12 (link),17 (link)].

Chrysochou C., Green D., Ritchie J., Buckley D.L, & Kalra P.A. (2017). Kidney volume to GFR ratio predicts functional improvement after revascularization in atheromatous renal artery stenosis. PLoS ONE, 12(6), e0177178.

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Multimodal MRI Acquisition Protocol

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MRI scans were acquired using one of four MRI scanners, including two of 3.0-Tesla (Discovery MR750, General Electric Medical Systems, Chicago, IL, USA and Acheiva, Philips Medical Systems, Best, Netherlands) and two of 1.5-Tesla (MAGNETOM Espree, Siemens, Germany and Optima MR360, General Electric Medical Systems, Chicago, IL, USA). Nearly three quarters (73.8%) of the MRI data were acquired with 3.0T. 2D T2-weighted images (T2WI) were used for evaluation, which were acquired with the same resolution as with the T1-weighted images in this dataset. Parameter settings were: TR/TE = 2500–5600/90–110 ms, flip angle = 90° or 140–160°, field of view = 230 × 230 mm, matrix = 180 × 256, slice thickness = 5.0 mm no gap, 24 axial slices to cover the whole brain.

Gu T., Fu C., Shen Z., Guo H., Zou M., Chen M., Rockwood K, & Song X. (2019). Age-Related Whole-Brain Structural Changes in Relation to Cardiovascular Risks Across the Adult Age Spectrum. Frontiers in Aging Neuroscience, 11, 85.

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MRI Neuroimaging Protocol for Autism Spectrum Disorder

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Imaging was performed with 3 Tesla MRI (Acheiva, Philips) using an 8 channel dedicated head coil as per the standard operating procedure under anesthesia, if required. The MRI scans were obtained by first performing a three-plane localizer scan, followed by an axial turbo spin-echo T2-weighted scan (TR/TE 3270/80 ms, flip angle 90°, field of view (FOV) 250 mm, acquisition voxel size 0.89/1.21/5.00 mm, slice thickness/gap 5 mm/1 mm); T2-weighted fluid attenuation and inversion recovery sense (TR/TE 11000/120 MS, flip angle 90°, FOV 250 mm, ACQ voxel size 0.96/1.79/5.00 mm, slice thickness/gap 5 mm/1 mm). Three-dimensional magnetization prepared rapid gradient echo volumetric acquisition of the whole-brain were acquired (TR/TE = 8.3/3.8 ms, sense factor = 1.5, flip angle = 8°, FOV = 256, acquisition voxel size 1/1/1 mm). DTI was done in 32 directions (DWISE, TR/TE = 8987/61.2 ms, no of slices 70, FOV 224 mm, acquisition voxel size 2/2/2 mm, slice thickness/gap = 2 mm/0 mm, no of directions 32, b values = 0, 1000). Total scan time was 35 min. All the children with autism required some form of sedation for the acquisition of MRI data under the monitoring by a neuroanesthesiologist. There were no anesthesia-related complications.

Assis Z.A., Bagepally B.S., Saini J., Srinath S., Bharath R.D., Naidu P.R, & Gupta A.K. (2015). Childhood autism in India: A case-control study using tract-based spatial statistics analysis. Indian Journal of Psychiatry, 57(3), 272-277.

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Multi-parametric MRI of Tumor Characteristics

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Patients were imaged on a 1.5T whole body scanner (Philips Acheiva, Philips Medical Systems) using an 8-channel head coil. Imaging included anatomical sequences before and after contrast agent administration for measurement of tumor volume. Diffusion-weighted images (DWIs) were collected using 3 B values (0, 400, and 800 s/mm³). DCE-MRI data were collected using a dual-injection technique, as described previously.^{16 (link)} Contrast agent (CA; gadoterate meglumine; Dotarem, Geurbet S.A.) was administered by power injector as an intravenous bolus at a rate of 3 mL/s, followed by a chaser of 20 mL/s of 0.9% saline administered at the same rate. A high temporal resolution (1 s) sequence with a low dose of contrast agent (0.02 mmol/kg) was performed (LDHT-DCE) to allow accurate measurement of the arterial input (AIF) and tissue residue functions. Subsequently, a full CA dose (0.1 mmol/kg), high-spatial resolution (voxel size = 1 × 1 × 2 mm) acquisition (FDHS-DCE) was performed to provide high spatial resolution data and scaling of the AIF. Variable flip angle (VFA; α = 2°, 8°, 15° and 20°) acquisitions were performed prior to the LDHT DCE series for native longitudinal relaxation rate (R1_N) mapping.

Li K.L., Djoukhadar I., Zhu X., Zhao S., Lloyd S., McCabe M., McBain C., Evans D.G, & Jackson A. (2015). Vascular biomarkers derived from dynamic contrast-enhanced MRI predict response of vestibular schwannoma to antiangiogenic therapy in type 2 neurofibromatosis. Neuro-Oncology, 18(2), 275-282.

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Structural and Functional MRI Protocol

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Scans for both tasks were performed at the Boston University Center for Biomedical Imaging using a 3 Tesla Philips Acheiva MRI scanner. Structural T1 scans were taken with 140 sagittal slices, 1 mm³ voxels, 240 × 240 matrix, FOV of 240 mm, flip angle of 8, fold-over direction of AP, TR of 8.2 ms, and TE of 3.8 ms. BOLD signal information was obtained using 31 axial slices (3 mm thick, 0.3 interslice gap), 3 mm³ voxels, 80 × 78 matrix, FOV of 240, a flip angle of 90, fold-over direction of AP, TR of 2000 ms and TE of 35 ms.

Sims J.A., Kapse K., Glynn P., Sandberg C., Tripodis Y, & Kiran S. (2016). The Relationships between the Amount of Spared Tissue, Percent Signal Change, and Accuracy in Semantic Processing in Aphasia. Neuropsychologia, 84, 113-126.

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Multimodal Body Composition Assessment

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Weight and height were measured pre- and post- intervention, and BMI was calculated. Waist circumference was measured using the Gulick II tape measure directly on the skin. Fat mass and fat-free mass were determined by dual-energy X-ray absorptiometry (DXA) using a GE Lunar (GE Healthcare, UK).
Additionally, abdominal and thigh adipose tissue (AT) and muscle volume was measured by MRI at baseline and following treatment on a 3 Tesla magnet (Philips Acheiva) at AH TRI. The MRI scan was performed at the mid-point of the femur to quantify thigh muscle cross-sectional area, subcutaneous, and intermuscular AT (IMAT). For abdominal AT images, high resolution axial images were taken of the entire abdomen to quantify abdominal subcutaneous and visceral AT volume. Resultant images were analyzed using Analyze 11.0 (Biomedical Imaging Resource, Mayo Clinic, Rochester, MN) to segment AT and muscle depots and measure volume.

Brennan A.M., Standley R.A., Yi F., Carnero E.A., Sparks L.M, & Goodpaster B.H. (2020). Individual Response Variation in the Effects of Weight Loss and Exercise on Insulin Sensitivity and Cardiometabolic Risk in Older Adults. Frontiers in Endocrinology, 11, 632.

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Multiparametric MRI Assessment of Cerebrovascular Function

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Scanning was performed on a 1.5 Tesla whole body scanner (Philips Acheiva, Philips Medical Systems, NL) using an 8-channel phased array head coil. The MR protocol consisted of 1) T1 inversion recovery (axial, TR/TE/TI −4572/15/400 ms, slice thickness 2 mm); 2) T2 fluid attenuated inversion recovery (axial, TR/TE/TI −6000/120/2000 ms, slice thickness 2 mm); 3) Survey phase contrast angiography to locate vessels for flow analysis (TR/TE −20/6.4 ms); 4) Quantitative Phase contrast imaging (QPC) of the carotid and basilar arteries (velocity encodation (VENC) 120 cm/s) and cerebral aqueduct (VENC 8 cm/s). 6) Axial SPIR FLAIR image of the orbit (TR/TE/TI −8000/120/2200 ms); 7) Coronal T2 SPIR of the orbit (TR/TE −3085/120 ms, slice thickness 2 mm).

Mercieca K., Cain J., Hansen T., Steeples L., Watkins A., Spencer F, & Jackson A. (2016). Primary Open Angle Glaucoma is Associated with MR Biomarkers of Cerebral Small Vessel Disease. Scientific Reports, 6, 22160.

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Spinal Column MRI Imaging Protocol

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After 3DSS, the participant underwent MRI scanning on a rigid substrate in the lateral position with fiducial markers adhered to the spinal column. The participant had fiducial markers, in the form of vitamin D capsules, adhered to the 3DSS stickers along the spinal column. Vitamin D capsules were used as they displayed excellent contrast, and image clarity was sufficient for capturing the spinous processes. The participant was then relocated to the gantry of a clinical MRI scanner where they were repositioned with the same postural criterion as was used for the 3DSS. A T1-weighted MRI sequence (3-T Philips Acheiva, Echo time 1.725 ms, Repetition time 3.82 ms, In-plane resolution 0.708 x 0.708 mm, Slice spacing 0.75 mm, Scan duration 12 minutes) was used, capturing a field of view from the lower cervical spine to the femoral head with full skin envelope.

Rayward L., Pearcy M., Izatt M., Green D., Labrom R., Askin G, & Little J.P. (2023). Predicting spinal column profile from surface topography via 3D non-contact surface scanning. PLOS ONE, 18(3), e0282634.

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