Our protocol for immunosuppression has been described elsewhere [20 (link)]. In brief, since 1999, induction therapy consists of an IL2 receptor antagonist (IL2RA) for 6–8 weeks post-transplant in normal-risk recipients and rabbit ATG or alemtuzumab in high-risk recipients (liverfree allografts, presensitized, and re-transplant patients). Maintenance immunosuppression is tacrolimus (Prograf; Astellas, Deerfield, IL) – based and also includes mycophenolate mofetil (Cellcept; Genentech, San Francisco, CA) or sirolimus (Rapamune; Pfizer, Philadelphia, PA). For induction and maintenance, all recipients are given corticosteroids which are typically weaned off in 1–3 years.
Cellcept
Manufactured by Genentech
Cellcept is a laboratory product designed for use in cell culture applications. It functions as an immunosuppressant agent that inhibits the proliferation of T and B lymphocytes.
Automatically generated - may contain errors
Lab products found in correlation
2 protocols using cellcept
1
Immunosuppression Protocol for Transplant
2
Immunosuppression and Antibiotic Regimen
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For the first 2 days, CellCept (500 mg, Genentech) was pumped through a nasogastric tube at a dose of 1 g/day, and Solu-Medrol (40 mg, Pfizer Inc.) in 500 mL of 5% dextrose solution was injected into the femoral vein. This intravenous infusion of 40 mg of Solu-Medrol was administered twice daily, in the morning and afternoon. In the following days, only 40 mg of Solu-Medrol was used, in the form of an intramuscular (buttock) injection of two ampoules per day.
Antibiotics were used according to a prophylactic antibiotic regimen. A single dose of cefuroxime (750 mg) was injected intravenously 30 minutes prior to skin incision.
Antibiotics were used according to a prophylactic antibiotic regimen. A single dose of cefuroxime (750 mg) was injected intravenously 30 minutes prior to skin incision.
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