All of the participants (patients and healthy controls) were examined using an identical MR protocol. All data were obtained using a 3T Magnetom Verio MR Scanner (Siemens, Erlangen, Germany) equipped with a 12-channel head coil. The MR imaging protocol included localiser scout imaging, sagittal 3D FLAIR (fluid attenuated inversion recovery) sequence (TI/TE/TR, 1800 ms/395 ms/5000 ms; 160 contiguous slices; isotropic voxel size, 1 × 1 × 1 mm3; bandwidth, 781 Hz/pixel) and sagittal 3D MPRAGE (Magnetization Prepared Gradient Echo) T1-weighted images (TI/TE/TR, 900 ms/2.92 ms/1900 ms; flip angle, 9°; 176 contiguous slices; isotropic voxel size, 1 × 1 × 1 mm3; bandwidth, 200 Hz/pixel), and transverse proton, density-weighted, spoiled gradient-echo sequences (750/4.5 ms [TR/TE], 44 contiguous slices; 3-mm section thickness; 30° flip angle; 320 mm FOV, 256 × 256 matrix) performed without and with magnetisation transfer (MT) saturation (1.5-kHz off-water resonance, pulse duration 500 μ).
Magnetom verio mr scanner
Manufactured by Siemens
Sourced in Germany
The Magnetom Verio MR Scanner is a magnetic resonance imaging (MRI) system developed by Siemens. It is designed to provide high-quality imaging capabilities for a variety of medical applications.
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Lab products found in correlation
5 protocols using magnetom verio mr scanner
1
Multimodal MRI Protocol for Brain Imaging
2
3T MRI Scanning Protocol for Brain Imaging
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MRI scanning was performed on a 3 Tesla Magnetom Verio MR Scanner (Siemens Medical Solutions, Erlangen, Germany) with an 8-channel birdcage type of head coil. Anatomical T1-weighted images were acquired using a three-dimensional magnetization-prepared rapid acquisition gradient-echo sequence with repetition time (TR)/echo time (TE)=1,900/2.35 ms, field-of-view (FOV)=22×22cm2, matrix size=256×256, number of excitation (NEX)=1 and slice thickness=1 mm. Functional images were acquired from a total of 25 axial slices parallel to an anterior commissure to posterior commissure line using a gradient-echo echo planner image (GRE-EPI) with the follow parameters: TR/TE=2,000/30 ms, flip angle=90°, FOV=22×22 cm2, metrix size=64×64, NEX=1, and slice thickness=5 mm without a slice gap.
3
3T Structural and Functional MRI Acquisition
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All the participants underwent a 3 Tesla Magnetom Verio MR Scanner (Siemens Medical Solutions, Erlangen, Germany) with an 8-channel birdcage type of head coil. The high resolution T1 weighted images were acquired using a three dimensional magnetization prepared rapid acquisition gradient echo (3D MP-RAGE) sequence with repetition time (TR)/echo time (TE) = 1,900/2.35 ms, field-of-view (FOV) = 22 × 22 cm2, matrix size = 256 × 256, number of excitation (NEX) = 1 and slice thickness = 1 mm. Functional images were acquired using a gradient-echo echo planner image (GRE-EPI) with the follow parameters: TR/TE = 2,000/30 ms, flip angle = 90°, FOV = 22 × 22 cm2, matrix size = 64 × 64, NEX = 1, number of slice = 25 and slice thickness = 5 mm without a slice gap.
4
MRS Analysis of DLPFC in GAD Patients
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Subjects were examined using a 3T Magnetom Verio MR Scanner (Siemens Medical Solutions, Erlangen, Germany) with a birdcage head coil. The high- After T1WI had been obtained, the single-voxel 1 H-MRS measurements were performed using a point-resolved spectroscopy (PRESS) sequence with TR/TE = 2000/30 ms, 96 acquisitions (scanning time 3 min and 13 s), 1200 Hz spectral width, 1024 data points, and 8 cm 3 (20 × 20 × 20 mm 3 ) voxel size. Also, MRS was performed with a short echo time (TE, 30 ms) to detect metabolites with short T2 relaxation time, such as glutamate/glutamine (Glx), lipid (Lip), and myo-inositol (mI). 19 The voxel was localized in the right DLPFC (Fig. 1), one of the key centers associated with emotional regulation and cognitive processes in patients with GAD. 5, 6 Prior to the MRS experiment, manual shimming of the B0 magnetic field and optimization of the transmitter pulse power were performed. To ensure the reproducibility of spectral quality, a full-width at half maximum (FWHM) of the water peak was measured. The FWHM at 4.7 p.p.m. were in the range of 12-19 Hz. Water suppression was accomplished with three 50-Hz bandwidth chemical-shift-selective saturation pulses, followed by spoiling gradients at the beginning of data acquisition.
5
Brain Imaging Protocol for Cognitive Tasks
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Brain imaging for both datasets was performed on the same 3T Siemens Magnetom Verio MR scanner (Siemens Medical Systems, Erlangen, Germany) with a standard 32channel head coil. In both samples, subjects were instructed to keep their eyes open and not to fall asleep during the acquisition period.
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