Telmisartan, candesartan, losartan and valsartan were obtained from LKT Laboratories (St. Paul, MN, USA), and prepared as 10 mg/mL stock solutions in dimethyl sulfoxide (DMSO). GW9662 and troglitazone were obtained from Cayman Chemical (Ann Arbor, MI, USA). GW9662 was prepared as a 5 mg/mL stock solution in dimethyl formamide. troglitazone was prepared as a 10 mg/mL stock solution in DMSO. The stock solutions were stored as aliquots at −20°C.
Valsartan
Manufactured by LKT Laboratories
Sourced in United States
Valsartan is a pharmaceutical ingredient used in the production of various medications. It functions as an angiotensin II receptor antagonist, which helps to regulate blood pressure by blocking the effects of a hormone called angiotensin II. This product is intended for use in regulated pharmaceutical manufacturing processes.
Automatically generated - may contain errors
Lab products found in correlation
Losartan, by LKT Laboratories (1 mentions)
Troglitazone, by Cayman Chemical (1 mentions)
Gw9662, by Cayman Chemical (1 mentions)
Acetaminophen, by Merck Group (1 mentions)
Aminopyrine, by Fujifilm (1 mentions)
Nevirapine, by Tokyo Chemical Industry (1 mentions)
Forskolin, by Fujifilm (1 mentions)
Sulfamethoxazole, by Fujifilm (1 mentions)
Tienilic acid, by Merck Group (1 mentions)
Tert butylhydroquinone, by Merck Group (1 mentions)
Dulbecco s modified eagle s medium dmem, by Nissui Pharmaceutical (1 mentions)
Warfarin, by LKT Laboratories (1 mentions)
3 protocols using valsartan
1
Angiotensin II Receptor Antagonists Preparation
2
Preparation of Stock Solutions for Cell Culture
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Acetaminophen, tert-butylhydroquinone, and tienilic acid were purchased from Sigma-Aldrich (St. Louis, MO, USA). Aminopyrine, sulfamethoxazole, and forskolin were purchased from Fujifilm Wako Pure Chemical Co. (Osaka, Japan). Erythromycin, valsartan, and warfarin were purchased from LKT Laboratories, Inc. (St Paul, MN, USA). Nevirapine, pravastatin, and procainamide were purchased from Tokyo Chemical Industry Co., Ltd. (Tokyo, Japan). Stock solutions of all test drugs were prepared in dimethyl sulfoxide (DMSO) at a concentration of 200 mM. Each solution was adequately diluted with Dulbecco's modified Eagle's medium (DMEM) (Nissui Pharmaceutical Co., Ltd., Tokyo, Japan) so that the final concentration of DMSO in the culture medium was 0.5%.
3
Antitumor Efficacy of Angiotensin II Receptor Antagonists
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Six to eight‐week‐old C57B/6 and Balb/c mice were inoculated s.c. in the flank with 4 × 105 MC38 and with 4 × 105 CT26 cells on day 0, respectively. Mice were injected i.p. with vehicle (PBS), valsartan (15 mg/kg; LKT Laboratories, St Paul, MN, USA), or candesartan (6 mg/kg; Funakoshi, Tokyo, Japan) every day from day 6. In the combined therapy, anti‐PD‐L1 or isotype antibody (Ab) (200 μg/body; Bio X Cell, Lebanon, NH, USA) was given on day 7, 10, and 13. For cell depletion, Anti‐CD8 or isotype Ab (200 μg/body; Bio X Cell) was given i.p. on day 1, 4, 5, 6, 12, and 19. Tumor size was measured using the following formula: volume = 0.5 × (width)2 × (length). Tumor antigen (gp70)‐specific T‐cell responses were detected by modification of our previously reported method.19 See Appendix S1 for more information.
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