For long-term experiments, one day after ID8-VEGF tumor inoculation, mice were injected weekly with 40 μg anti-VEGF-A antibody (∼2 mg kg−1; clone G6-31; gift of Genentech), given daily gavage with 2 mg aspirin (∼100 mg kg−1; Cayman Chemical), or treated with both interventions. Control mice were given equal amounts of mouse IgG. For long-term experiments with anti-FasL antibody (clone MFL3), mice were given three 25 μg intratumoral injections a week.
Anti vegf a antibody
Manufactured by Genentech
Sourced in United States
The Anti-VEGF-A antibody is a laboratory tool designed for research purposes. It functions as a specific binder to Vascular Endothelial Growth Factor A (VEGF-A), a protein known to play a crucial role in the regulation of angiogenesis, the process of new blood vessel formation. This antibody can be utilized in various experimental techniques to study the interactions and effects of VEGF-A in biological systems.
Automatically generated - may contain errors
3 protocols using anti vegf a antibody
1
Anti-VEGF and Aspirin Combo Therapy
2
Anti-VEGF and Aspirin Combo Therapy
3
CAR-T Cell Binding to VEGFR-2
Check if the same lab product or an alternative is used in the 5 most similar protocols
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CAR-T cells were incubated with 10 µg/mL recombinant mVEGFR-2-hIgG-Fc fusion protein (R&D Systems) in the presence of control protein or soluble murine VEGF-A (VEGF-164, BioLegend), VEGF-C (BioLegend), or VEGF-D (R&D Systems), at a VEGF/VEGFR-2 molar ratio of 3:1 in a total volume of 10 μL. Alternatively, VEGF-A was incubated with anti-VEGF-A antibody (Clone B20‐4.1.1; a kind gift from Genentech, San Francisco, California, USA) at a VEGF-A:anti-VEGF-A antibody molar ratio of 1:3 for 30 min at 37°C prior its addition to CAR-T cells. The cells were then washed and stained to evaluate mVEGFR-2-hIgG-Fc binding levels on the CAR-T cells as described above.
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