HDCT scans were performed on 15 different scanners of 4 different CT manufacturers: 5 General Electric scanners (a Brightspeed, a Lightspeed Plus, a Lightspeed VCT, a Optima CT520 series, and a Optima CT660), 5 Siemens scanners (a Somatom Definition Flash, a Sensation 16 and a Scope), 2 Toshiba scanner (a Aquilion and a Asteion), and 2 Philips scanner (a Brilliance 64 and a Brilliance 16). The acquisition parameters were: tube voltage settings were selected 100, 120 and 130 kV and tube current in a range of values from 65 to 389 mAs (mean 150). The CT images were reconstructed using a 512 × 512 matrix and standard filter. Contrast enhancements venous phase images were used for the measurements in 35 examinations, while in the remaining 55 cases not-enhanced images were selected. The main technical features are resumed in Supplementary Table 1 .
Lightspeed plus
Manufactured by Siemens
LightSpeed Plus is a lab equipment product manufactured by Siemens. It is a specialized device designed for precise and efficient data acquisition and analysis. The core function of LightSpeed Plus is to enable seamless data processing and measurement capabilities for various scientific and research applications.
Automatically generated - may contain errors
Lab products found in correlation
Lightspeed ultra, by Siemens (4 mentions)
Volume zoom, by Philips (3 mentions)
Mx8000, by Philips (3 mentions)
Optima ct660, by Siemens (1 mentions)
Brilliance 16, by Toshiba (1 mentions)
Somatom definition flash, by Toshiba (1 mentions)
Sensation 16, by Toshiba (1 mentions)
Brightspeed, by Siemens (1 mentions)
Brilliance 64, by Toshiba (1 mentions)
Lightspeed vct, by Siemens (1 mentions)
Somatom plus 4, by Siemens (1 mentions)
5 protocols using lightspeed plus
1
Multi-vendor CT Scanner Protocols
2
Quantifying Coronary Artery Calcification
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Cardiac CT examinations were obtained using General Electric Health Systems LightSpeed Plus and LightSpeed Ultra, Siemens Volume Zoom, or Philips MX 8000 machines. The cardiac CT examination details have been reported previously [19 (link)]. Cardiac CT images were initially obtained from all sites and the images were then sent electronically to the central CT reading center located at Wake Forest University Health Sciences, Winston Salem, NC. A trained CT analysts identified CAC in the epicardial coronary arteries using Agatston score. Agatston score refers to the amount of calcium based on the area and the density of the calcified plaques as detected by the scan [23 (link)]. In this study, the sum of the vessel plaque as averaged from the first and second measurement is reported as the total CAC score.
3
Measuring Coronary Artery Calcium Scores
4
Cardiac Calcium Scoring Protocol
5
Acute Brain Imaging Protocol for Clinical Trials
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CT-scans were performed with three different units (GE Medical System Light Speed Ultra or Light Speed Plus, Siemens Somatom Plus 4). Helical transverse scans were obtained from skull base to top of head. X-ray tube voltage was 120 kV or 140 kV. Image slice thickness was 5 mm (7,5 mm supratentorium in Siemens Somatom Plus 4). CECT scans were obtained after injection of contrast medium (Omnipaque 350 mg/ml).
The neuroradiologist (P.V.) reviewed all scans blinded to information other than the time of birth and sex of the patient. Emergent imaging findings prompting acute changes in treatment were predefined as intracranial haemorrhage, acute ischemia, CNS infection, mass effect, midline shift, obstructive hydrocephalus and/or generalized or focal brain oedema. This definition was chosen, as these pathologies prompt either surgical intervention, initiation of medication (e.g. anticoagulation, antibiotics or corticosteroid treatment), or hospitalization. NCCT and CECT images were analyzed separately, in a randomized manner. A structured eCRF (Openclinica) was filled in for each image.
The neuroradiologist (P.V.) reviewed all scans blinded to information other than the time of birth and sex of the patient. Emergent imaging findings prompting acute changes in treatment were predefined as intracranial haemorrhage, acute ischemia, CNS infection, mass effect, midline shift, obstructive hydrocephalus and/or generalized or focal brain oedema. This definition was chosen, as these pathologies prompt either surgical intervention, initiation of medication (e.g. anticoagulation, antibiotics or corticosteroid treatment), or hospitalization. NCCT and CECT images were analyzed separately, in a randomized manner. A structured eCRF (Openclinica) was filled in for each image.
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