Statistics for windows version 22

Categorical variables were expressed as absolute frequency (n) and relative frequency (%). Continuous variables were expressed as measures of central tendency (mean and median) and dispersion (standard deviation and interquartile range). Categorical variables were compared using the χ² test or the Fisher exact test, as appropriate. When 2 means were compared, the t test (parametric) or the Mann-Whitney test (nonparametric) was used, as appropriate, and 3 means were compared using analysis of variance (parametric) or the Kruskal-Wallis test (nonparametric), as appropriate. Time-to-event (mortality, total bleeds, and admissions to the intensive care unit) curves were constructed using an unadjusted Kaplan-Meier method. The log-rank test was used to compare outcomes according to anticoagulant therapy, dose of edoxaban, and dose of LMWH. A Cox regression model adjusted for potential confounders was constructed. Age, sex, hypertension, diabetes, prior myocardial infarction, and heart failure were included as potential cofactors, and log-likelihood was calculated. Effect sizes were presented as hazard ratio and 95% confidence interval. Statistical significance was set at 0.05 for all the tests. The data were analyzed using the statistical package IBM Statistics for Windows, Version 22.0 (IBM Corp).