Brahms pct assay

Manufactured by Roche

Sourced in Japan

The BRAHMS PCT assay is a laboratory test developed by Roche that measures the levels of procalcitonin (PCT) in a patient's blood sample. PCT is a biomarker that can help clinicians assess the likelihood of a bacterial infection. The BRAHMS PCT assay provides quantitative results, allowing healthcare professionals to use PCT levels to aid in the diagnosis, management, and monitoring of certain inflammatory conditions and infections.

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Lab products found in correlation

Crp 2 latex x2, by Denka Seiken (1 mentions) Xt 1800i, by Sysmex (1 mentions) Pathfast, by Mitsubishi (1 mentions) Cleia, by Mitsubishi (1 mentions)

2 protocols using brahms pct assay

Sepsis Biomarker Monitoring Protocol

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Height and body weight were measured, and body mass index (BMI) was calculated (weight in kilogram divided by square of height in meter). Venous blood samples were obtained in the emergency room at presentation and after 1-week of sepsis treatment, and complete blood count (CBC), C-reactive protein (CRP) and PCT were measured. CBC was performed by the electrical impedance method. C-reactive protein was quantified by latex-enhanced nephelometry. Serum PCT level, measured using the Elecsys BRAHMS PCT assay (Roche Diagnostics K.K, Swiss) based on the ELISA method,20 (link) was also converted to logarithmic scale as ln(PCT) to curb departure from normality.

Nagayama D., Imamura H., Endo K., Saiki A., Sato Y., Yamaguchi T., Watanabe Y., Ohira M., Shirai K, & Tatsuno I. (2019). Marker Of Sepsis Severity Is Associated With The Variation In Cardio-Ankle Vascular Index (CAVI) During Sepsis Treatment. Vascular Health and Risk Management, 15, 509-516.

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Biomarker Measurement in EDTA Plasma

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Blood samples were routinely collected for measuring markers, and there were no lack of data on ICU admission in this study. CRP levels were measured by CRP-LATEX (II) X2 “SEIKEN” (Denka Seiken Co., Ltd, Tokyo, Japan) using EDTA plasma as a sample. PCT levels were measured by the Elecsys BRAHMS PCT assay (Roche Diagnostics, Tokyo, Japan) using EDTA plasma as a sample. PSEP levels were measured using a compact-automated immunoanalyzer, PATHFAST, based on a chemiluminescent enzyme immunoassay (CLEIA) (Mitsubishi Chemical Medience Corp., Japan). Platelet counts were measured in whole blood using an XT-1800i (Sysmex Co., Kobe, Japan). PT, APTT, AT, D-dimer, PIC, PC, and SF levels were measured in the plasma using a Coapresta 2000 (Sekisui Medicak, Tokyo, Japan). TAT, TM, and PAI-1 levels were measured using a STACIA (Mitsubishi Chemical Medience Corp., Tokyo, Japan). Total PAI-1 including active PAI-1 and tPA-PAI-1 complex was defined as PAI-1 in this study.

Hoshino K., Kitamura T., Nakamura Y., Irie Y., Matsumoto N., Kawano Y, & Ishikura H. (2017). Usefulness of plasminogen activator inhibitor-1 as a predictive marker of mortality in sepsis. Journal of Intensive Care, 5, 42.

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