Ingenia elition 3.0 t x

A 31-year-old female volunteer was enrolled for the experiment, and three-dimensional thin-slice magnetic resonance imaging (MRI) of her left knee joint was performed (0.4 mm × 0.4 mm × 0.4 mm, Ingenia Elition 3.0 T X, Philips, The Kingdom of the Netherlands). MRI indicated that no structural diseases were present.

Anatomical cross-sectional area (ACSA) (cm²) and volume (cm³) of the involved thigh musculature will be measured using magnetic resonance imaging (MRI) with a Philips Ingenia Elition 3.0T X (Philips Healthcare, Best, The Netherlands). A T1-weighted, spin echo, axial plane sequence will be obtained with contiguous transverse images from the greater trochanter to the lateral condyle of the femur with a 1.0 cm slice thickness and no inter-slice gap. The MRI data will be anonymised and transferred onto a study laptop for analysis using a public domain image analysis software (Image J, v1. 48, National Institutes of Health, Bethesda, USA). For each slice, ACSA and volume will be calculated for each muscle within the quadriceps femoris and for the global hamstring compartment. Inter- and intra-rater reliability will be calculated from the repeated analysis of the first five MRI scans.

All patients were examined on two 3.0 T Philips scanners (Ingenia Elition 3.0 T X and Ingenia 3.0 T; Philips Medical Systems, Best, The Netherlands) with a 20-channel head-neck coil. In addition to conventional anatomic sequences, each MRI consists of 3D APTw, DWI and the corresponding ADC maps. All image processing and reconstruction algorithms were automatically implemented on MRI scanning system. Among them, the APT sequence encompasses two sets of images: one set is APTw images, and the other set is S0 images. Both sets of images possess the identical spatial resolution. The S0 images represent the control signal intensity without saturation, and the imaging is performed at a frequency offset of − 1560 ppm [11 (link)]. Detailed information on imaging parameters are available in the Supplementary Table 1, Additional File 1.