Polestar m660

The DOTA-CPCR4-2 peptide was purchased from CSBio Co (CA 94025, USA). The radiolabeling of ⁶⁸Ga-pentixafor was performed manually before injection according to the procedures as previously published. ¹⁸F-FDG was synthesized in house with an 11 MeV cyclotron (CTI RDS 111, Siemens, Germany). The PET scans were performed with dedicated PET/CT scanners (Biograph 64 Truepoint TrueV, Siemens, Germany; Polestar m660, SinoUnion, China) from the tip of the skull to the middle thigh. For ¹⁸F-FDG PET/CT, the patients fasted for at least 6 h, and the blood glucose levels were monitored (4.7–6.9 mmol/L) before an injection of ¹⁸F-FDG (5.55 MBq/kg). The PET/CT images (2 min/bed) were acquired with an uptake time of 75.0 ± 13.2 (mean ± SD) min. For ⁶⁸Ga-pentixafor PET/CT, imaging was performed (2–4 min/bed) with an uptake time of 45.9 ± 19.7 min after an injection of 85.1 ± 27.4 MBq of ⁶⁸Ga-pentixafor. The acquired data were reconstructed using the ordered-subset expectation maximization method (Biograph 64: 2 iterations, 8 subsets, Gaussian filter, image size of 168 × 168; Polestar m660: 2 iterations, 10 subsets, Gaussian filter, image size of 192 × 192).

The DOTA-FAPI-04 peptide was purchased from CSBio Co (Menlo Park, CA). The radiolabeling of [⁶⁸ Ga]Ga-FAPI-04 was performed manually before injection according to the procedures as previously published [22 (link)]. [¹⁸F]FDG was synthesized in-house with an 11 MeV cyclotron (CTI RDS 111, Siemens, Germany). The PET scans were performed on dedicated PET/CT scanners (Biograph 64 Truepoint TrueV, Siemens, Germany; Polestar m660, SinoUnion, China). For [¹⁸F]FDG PET/CT, the patients fasted for over 6 h, and the blood glucose levels were monitored (4.5–7.8 mmol/L) prior to an injection of [¹⁸F]FDG (5.55 MBq/kg). The PET/CT images (2 min/bed) were acquired with an uptake time of 75.6 ± 15.1 min. For [⁶⁸ Ga]Ga-FAPI-04 PET/CT, imaging was performed (2 min/bed) with an uptake time of 51.2 ± 13.2 min after an injection of 103.6 ± 33.3 MBq [⁶⁸ Ga]Ga-FAPI-04. The PET/CT scan was obtained from the tip of the skull to the crus. The acquired data were reconstructed using the ordered-subset expectation maximization method.