2 hydropropyl β cyclodextrin hβcd

Manufactured by Merck Group

2-hydropropyl-β-cyclodextrin (HβCD) is a chemical compound used in various laboratory applications. It is a modified form of the naturally occurring cyclodextrin molecule. HβCD has the ability to form inclusion complexes with a variety of compounds, which can be utilized in numerous laboratory procedures.

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Lab products found in correlation

Cyclopamine, by Merck Group (2 mentions)

2 protocols using 2 hydropropyl β cyclodextrin hβcd

Smoothened Inhibition in Mice

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Sca1-eGFP mice were treated with the Smoothened inhibitor, cyclopamine,
or the vehicle 2-hydropropyl-β-cyclodextrin (HβCD)
(Sigma-Aldrich) alone as a control, (essentially as described by van den Brink
(van den Brink et al. 2001 (link))). Mice
were injected (250 μl max volume) intraperitoneally (IP) 1 day before
ligation, then every other day after ligation at a dose of 10 mg/kg cyclopamine
(Sigma-Aldrich) dissolved in a solution of 45% (w/v) HβCD. There
was no effect of cyclopamine treatment on mouse body weight, compared to the
HβCD vehicle control group (data not shown).

Fitzpatrick E., Han X., Liu W., Corcoran E., Burtenshaw D., Morrow D., Helt J.C., Cahill P.A, & Redmond E.M. (2017). Alcohol Reduces Arterial Remodeling by Inhibiting Sonic Hedgehog-Stimulated Sca1+ Progenitor Stem Cell Expansion. Alcoholism, clinical and experimental research, 41(12), 2051-2065.

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Smoothened Inhibitor Treatment in Mice

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Sca1-eGFP mice were treated with the smoothened inhibitor, cyclopamine, or the vehicle 2-hydropropyl-β-cyclodextrin (HβCD) (Sigma–Aldrich) alone as a control, (essentially as described previously)^{86 (link)}. Mice were injected (250 μl max volume) intraperitoneally (IP) 1 day before ligation, then every other day after ligation at a dose of 10 mg/kg cyclopamine (Sigma–Aldrich) dissolved in a solution of 45% (w/v) HβCD. There was no effect of cyclopamine treatment on mouse body weight, compared to the HβCD vehicle control group (data not shown).

Di Luca M., Fitzpatrick E., Burtenshaw D., Liu W., Helt J.C., Hakimjavadi R., Corcoran E., Gusti Y., Sheridan D., Harman S., Lally C., Redmond E.M, & Cahill P.A. (2021). The calcium binding protein S100β marks hedgehog-responsive resident vascular stem cells within vascular lesions. NPJ Regenerative Medicine, 6, 10.

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