Affymetrix 6.0 array set platform

Manufactured by Thermo Fisher Scientific

The Affymetrix 6.0 Array Set Platform is a high-density microarray system designed for comprehensive genome-wide association studies. It features over 906,600 markers, including more than 906,600 single nucleotide polymorphisms (SNPs) and 946,000 probes for the detection of copy number variations (CNVs).

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Affymetrix 6.0 platform Affymetrix 6.0 array 6.0 platform 6.0 array Affymetrix platform Array 6.0

2 protocols using affymetrix 6.0 array set platform

Genotype Imputation with HRC and PBWT

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Genotype data produced from blood samples were acquired through dbGap. The data genotyping was completed using either the Illumina (Illumina, San Diego, California) or Affymetrix 6.0 Array Set Platform (Affymetrix, Santa Clara, California). Genotype imputation was completed at the Sanger Imputation Server. The Haplotype Reference Consortium (HRC) reference panel and Positional Burrows-Wheeler Transform (PBWT) imputation algorithm were used for genotype imputation.

Xiao X, & Wu Q. (2021). The Utility of Genetic Risk Score to Improve Performance of FRAX for Fracture Prediction in US Postmenopausal Women. Calcified tissue international, 108(6), 746-756.

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Genotype Imputation Using HRC

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The genotype data used in this study were obtained from blood samples and acquired through dbGap. Genotyping was performed using either the Illumina (Illumina, San Diego, California) or Affymetrix 6.0 Array Set Platform (Affymetrix, Santa Clara, California). Genotype imputation was carried out using the Sanger Imputation Server, employing the Haplotype Reference Consortium (HRC) reference panel and the Positional Burrows-Wheeler Transform (PBWT) imputation algorithm.

Xiao X, & Wu Q. (2023). Validation of a genome-wide polygenic score in improving fracture risk assessment beyond the FRAX tool in the Women’s Health Initiative study. PLOS ONE, 18(6), e0286689.

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