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L 165042

Manufactured by Merck Group
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Sourced in United Kingdom

L−165042 is a selective and potent agonist for the peroxisome proliferator-activated receptor delta (PPARδ). It is a laboratory research compound used to study the biological effects and mechanisms of PPARδ activation.

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Lab products found in correlation

Sodium nitrate, by Thermo Fisher Scientific (2 mentions) Sulfanilamide, by Merck Group (2 mentions) Orthophosphoric acid, by Thermo Fisher Scientific (2 mentions) Lps o55 b5, by Merck Group (2 mentions) Dimethyl sulfoxide (dmso), by Thermo Fisher Scientific (2 mentions) Gsk3787, by Merck Group (2 mentions) Gw0742, by Merck Group (2 mentions) Gsk0660, by Merck Group (2 mentions) β actin, by Thermo Fisher Scientific (2 mentions) Pdk 4, by Thermo Fisher Scientific (2 mentions) Angptl4, by Thermo Fisher Scientific (2 mentions) Naphthylethylenediamine dihydrochloride, by Merck Group (1 mentions)

2 protocols using l 165042

1

Ligand-Induced PPARβ/δ Signaling

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The PPARβ/δ ligands GW0742, GSK3787, L−165042 and GSK0660 as well as 1400W, LPS O55:B5, sulfanilamide and naphthylethylenediamine dihydrochloride were purchased from Sigma (Gillingham, Dorset, UK). Sodium nitrate, orthophosphoric acid and DMSO were purchased from Fisher Scientific (Loughborough, UK). Primers from Applied Biosystem (Foster City, CA, USA): β-actin (Rn00667869_m1), Pdk−4 (Rn00585577_m1), Angptl−4 (Rn015228817_m1), Nos2 (Rn00561646_m1).
Perez Diaz N., Lione L.A., Hutter V, & Mackenzie L.S. (2021). Co-Incubation with PPARβ/δ Agonists and Antagonists Modeled Using Computational Chemistry: Effect on LPS Induced Inflammatory Markers in Pulmonary Artery. International Journal of Molecular Sciences, 22(6), 3158.
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2

Ligand-Activated PPAR Signaling Pathway

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The PPARβ/δ ligands GW0742, GSK3787, L-165042 and GSK0660 as well as 1400W, LPS O55:B5, sulfanilamide and naphthylethylenediamine dihydrochloride were purchased from Sigma. Sodium nitrate, orthophosphoric acid and DMSO were purchased from Fisher Scientific.
Primers from Applied Biosystem: β-actin (Rn00667869_m1), Pdk-4 (Rn00585577_m1), Angptl-4 (Rn015228817_m1), Nos2 (Rn00561646_m1), Serpine-1 (Rn01481341_m1), Timp-1 (Rn01430873_m1), Id2 (Rn01495280_m1).
Diaz N.P., Lione L.A., Hutter V., & Mackenzie L.S. (2020). Modelling the effects of PPARβδ of innate inflammatory responses in lung tissues.
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