β propiolactone

Manufactured by Serva Electrophoresis

Sourced in Germany

β-Propiolactone is a laboratory chemical used as a sterilizing agent. It is a clear, colorless liquid with a characteristic odor. β-Propiolactone is used in various applications, including disinfection and sterilization processes.

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Lab products found in correlation

Capto core 700, by GE Healthcare (1 mentions)

Close spelling variants of this product

β-propiolactone (βpL)

2 protocols using β propiolactone

Large-Scale Influenza Virus Production

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sMDCK cells were cultured in a 40 L bioreactor (Bio-510, NBS, USA) for 72 h and inoculated with virus prepared in SPF eggs at 33 ± 1°C. To remove host cell protein and DNA, the harvest was clarified by depth filtration (PALL, USA), treated with benzonase, and purified by CaptoTM Core 700 (GE, USA) and CaptoTM Q (GE, USA). β-Propiolactone (Serva, Germany) was added to inactivate the virus. The solution (containing 128 μg/mL hemagglutinin [HA]) was stored at 4°C in phosphate-buffered saline (PBS). The placebo in this study was the PBS that was used to dilute the solution.

Zhang Z., Jiang Z., Deng T., Zhang J., Liu B., Liu J., Qiu R., Zhang Q., Li X., Nian X., Hong Y., Li F., Peng F., Zhao W., Xia Z., Huang S., Liang S., Chen J., Li C, & Yang X. (2022). Preclinical immunogenicity assessment of a cell-based inactivated whole-virion H5N1 influenza vaccine. Open Life Sciences, 17(1), 1282-1295.

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Inactivation and Immunization of SFTSV

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The SFTSV was inactivated by β-propiolactone (SERVA Electrophoresis GmbH, Heidelberg, Germany) as previously described [26] (link). Female BALB/c mice (6-8 weeks old, n = 6) were immunised with inactivated 10 8 TCID 50 SFTSV (200 μL/mouse) through both the intraperitoneal and subcutaneous routes, three times, two weeks apart. The fusion of hybridoma cells and the screening of antibodies were conducted using the same methods as previously described [26] (link).

Wu X., Moming A., Zhang Y., Wang Z., Zhang T., Fu L., Qian J., Ni J., Hu S., Tang S., Zheng X., Wang H., Shen S, & Deng F. (2024). Identification and characterization of three monoclonal antibodies targeting the SFTSV glycoprotein and displaying a broad spectrum recognition of SFTSV-related viruses. PLoS neglected tropical diseases, 18(6).

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