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Signa 3t scanner

Manufactured by GE Healthcare
Sourced in United States

The Signa 3T scanner is a high-field magnetic resonance imaging (MRI) system designed and manufactured by GE Healthcare. It operates at a magnetic field strength of 3 Tesla, which enables higher-quality imaging and improved signal-to-noise ratio compared to lower-field MRI systems. The Signa 3T scanner is capable of performing a variety of MRI imaging techniques and is suitable for a range of clinical applications.

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23 protocols using signa 3t scanner

1

Multimodal MRI Preprocessing Pipeline

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All patients were scanned in a GE Signa 3T scanner with an eight-channel head coil. DWI images were acquired at repetition time (TR)=12500ms and echo time (TE)=88.7ms, with a field of view (FOV)=24cm, a 128×128 acquisition matrix, and contiguous 3mm-thickness axial slices covering the whole brain, using 55 isotropic gradient directions with b=1000 s/mm2, number of excitations=1, and a single b=0 image. T1-weighted (T1w) images were also acquired using a fast spoiled gradient echo sequence (FSPGR) at repetition time (TR)=9.12ms, echo time (TE)=3.66ms, and inversion time (TI)=400ms, with slice thickness of 1.2mm and a planar resolution of 0.94×0.94 mm2. DWI was first denoised,26 (link) then corrected for inhomogeneity, distortions, and bias using the FMRIB software library (FSL) eddy tool27 (link) and automated segmentation tool (FAST)28 (link) package. Anatomical brain images were extracted from T1w scans using FreeSurfer software reconstruction29 (link) and co-registered to the corrected DWI averaged over all gradient directions. To facilitate the study of white matter pathways, the approximate grey matter white matter boundary was also identified on the T1w images using the FMRIB software library (FSL) automated segmentation tool (FAST) package.
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2

High-Resolution 3D T1-Weighted Brain Imaging

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Structural brain images were acquired on a GE Signa 3T scanner, using an axial three-dimensional (3D) T1-weighted magnetization-prepared rapid acquisition gradient echo (IR-prepped fast spoiled gradient recall, FSPGR, field of view 22 cm, flip angle 10°, slice thickness 1.2 mm, scan matrix 256×256, TR/TE/TI= 10/3/450 ms, ASSET, 1 NEX, voxel size 0.89 mm3).
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3

Multimodal MRI Protocol for Brain Imaging

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All MRI data acquisition was conducted on a GE Signa 3T scanner (Waukesha, WI) with a quad split quadrature transmit/receive head coil. Participants were screened for any contraindications to MRI. Imaging sessions lasted 1 hour and 15 minutes. The imaging paradigm included:
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4

Evaluating Cognitive Control Mechanisms in Modified Flanker Task

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The modified Flanker task [31 (link)] is an event-related task designed to evaluate response inhibition and interference suppression. Each session consisted of four experimental conditions and a total of 145 trials. Each trial was presented for 800 ms that included five symbols with the central arrow pointing left or right, flanked by four symbols, two on each side. In three conditions (‘congruent’, ‘incongruent’, ‘neutral’), the subjects were asked to indicate the direction of the central arrow on the screen while ignoring the four flankers. During the ‘No-Go’ condition, the subjects were instructed to withhold their motor response when the flankers were ‘X’s. In current project, we limited our analysis to the correct trials in the No-Go condition to focus on response inhibition process.
BOLD fMRI was performed on a GE Signa 3T scanner. A gradient EPI sequence was used to acquire 300 images (26 axial slices, 4 mm thickness with 1 mm gap, in-plane resolution = 3.75 × 3.75 mm2, FOV = 24 cm2, matrix = 64 × 64, TR/TE = 2000/28 ms, flip angle = 90°).
Images were preprocessed following the same procedures as NBack task (slice-timing correction, motion correction, spatial normalization and smoothing) in SPM5. A contrast image for response inhibition (No-Go) was generated per subject per session using the correct trials only.
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5

Neuroimaging of Eating Disorders

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Before brain imaging between 0800 and 0900 hours, eating-disorder individuals ate their meal plan breakfast; controls had a breakfast matched in quality and calories to the average meal plan breakfast. Brain images were acquired on a GE Signa 3T scanner: (1) diffusion-weighted imaging (DWI) included 25 DWI diffusion directions and one T2-weighted (b=0) baseline image; 45 slices per image in anterior–posterior commissure orientation (128x128 matrix, repetition time (TR)/echo time (TE)=16 000/82.6 ms, field of view=26 cm, b-value=1000, ASSET, slice thickness/gap=2.6/0 mm). (2) fMRI T2* weighted echo-planar imaging for blood oxygen-dependent functional activity was performed, voxel size 3.4 × 3.4 × 2.6 mm, TR 2100 ms, TE 30 ms, angle 70°, 30 slices, interleaved acquisition and 2.6 mm slice thickness with 1.4 mm gap.
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6

Functional Brain Imaging Protocol

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Brain images were acquired on a GE Signa 3T scanner for blood oxygen dependent (BOLD) T2* weighted echo-planar imaging (EPI), voxel size 3.4 × 3.4 × 2.6mm, TR 2100ms, TE 30ms, angle 70°, 30 slices, interleaved acquisition, 2.6mm slice thickness with 1.4mm gap.
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7

Neuroimaging of Subliminal and Liminal Rectal Stimuli

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Imaging acquisition was performed using a GE Signa 3T scanner (GE, Waukesha, Wisconsin, USA) with a standard 8-channel head coil at the Medical College of Wisconsin. Each fMRI run consisted of four repeating cycles, with each cycle comprising a 15-second pressure and a 25-second rest (Fig. 1A). Two scans were performed during each of the subliminal and liminal stimulation conditions. Participants were not informed of the type or level of rectal distension stimulation, be it subliminal or liminal, before the start of each scan in order to minimize the anticipatory effects in the acquired data. Functional blood-oxygen-level-dependent (BOLD) signals were acquired in the sagittal plane (repetition time, 2 s; echo time, 25 ms; slice thickness, 4 mm; in-plane resolution, 3.75 × 3.75 mm2; flip angle, 77°; field of view (FOV), 24 cm; matrix size, 64-by-64). The whole-brain high-resolution spoiled-gradient-recalled (SPGR) anatomical images were always obtained immediately after the completion of all fMRI runs (TR, 9.5 ms; TE, 3.9 ms; slices thickness, 1.2 mm; flip angle, 12°; FOV, 24 cm; matrix size, 256 × 224).
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8

BOLD fMRI Emotional Attentional Control

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We performed BOLD fMRI using a GE Signa 3T scanner (gradient-echo-planar-imaging sequence, time repetition/time echo = 2000/30 ms; 26 interleaved slices, thickness = 4 mm, gap = 1 mm; voxel size = 3.75 × 3.75 × 5 mm; scans = 260; flip angle = 90°; field of view = 24 cm; and matrix = 64 × 64) while subjects performed the emotional variable attentional control (EVAC) task. The first 4 scans were discarded to allow for signal saturation.
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9

Diffusion-Weighted MRI for White Matter Visualization

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Diffusion-weighted images were acquired as part of preoperative structural MR imaging to visualize white matter pathways underlying electrode sites. T1-weighted images were collected using a GE Signa 3T scanner with an eight-channel head coil and array spatial sensitivity encoding technique (ASSET). For T1-weighted images, a fast-spoiled gradient echo sequence was applied at TR/TE/TI of 9.12/3.66/400 ms, outputting 1.2 mm slices at 0.94×0.94 mm2 planar resolution. For diffusion-weighted images, a multi-slice, single-shot, diffusion-weighted echo-planar imaging sequence was applied at TR/TE of 12,500/88.7 ms with FOV = 24 cm. A 128×128 acquisition matrix at a nominal resolution of 1.89 mm with contiguous 3 mm slices covering the whole brain was obtained, outputting a single b = 0 (b0) image and 55 isotropic gradient directions with b = 1,000 s/mm2. Diffusion-weighted images were corrected for motion, noise, and susceptibility- and eddy-induced distortions using FSL80 and NIH TORTISE81 packages. Three-dimensional reconstructions the whole brain were generated using FreeSurfer software76 .
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10

Structural and Diffusion Brain Imaging

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Structural brain images were acquired on a GE Signa 3T scanner. Diffusion weighted images included 25 diffusion directions and one T2-weighted (b = 0) baseline image. Each image included 45 slices acquired in anterior-posterior commissure orientation (128 × 128 matrix, TR/TE = 16,000/82.6 ms, field of view = 26 cm, b-value = 1000, ASSET, slice thickness/gap = 2.6/0 mm).
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