The 68Ge/68Ga generator (50 mCi/day activity) was obtained from Pars Isotope (Karaj, Iran). DOTATOC was purchased from ABX (Radeberg, Germany), and the rest of chemical reagents were obtained from Sigma-Aldrich (Heidelberg, Germany). Moreover, Whatman No. 2 paper was purchased from Whatman Company (Buckinghamshire, U.K.).
Radio-chromatography was performed, using a thin-layer chromatography scanner (Bioscan AR2000, Paris, France), and imaging studies were conducted, using a dual-head SPECT system (DST-XL, Sopha Medical Vision, Buc, France). Activity of the samples was measured by a p-type coaxial high-purity germanium (HPGe) detector (EGPC 80-200R), coupled with a multi-channel analyzer card system (GC1020-7500SL, Canberra, USA).
Calculations were based on the 511 keV peak. All values were expressed as mean ± standard deviation (mean ± SD). The obtained data were compared, using student’s t-test. P-value less than 0.05 was considered statistically significant. Animal studies were performed in accordance with the guidelines by the United Kingdom Biological Council on the use of living animals in scientific investigations (second edition).
Radio-chromatography was performed, using a thin-layer chromatography scanner (Bioscan AR2000, Paris, France), and imaging studies were conducted, using a dual-head SPECT system (DST-XL, Sopha Medical Vision, Buc, France). Activity of the samples was measured by a p-type coaxial high-purity germanium (HPGe) detector (EGPC 80-200R), coupled with a multi-channel analyzer card system (GC1020-7500SL, Canberra, USA).
Calculations were based on the 511 keV peak. All values were expressed as mean ± standard deviation (mean ± SD). The obtained data were compared, using student’s t-test. P-value less than 0.05 was considered statistically significant. Animal studies were performed in accordance with the guidelines by the United Kingdom Biological Council on the use of living animals in scientific investigations (second edition).