Eclipse treatment planning system V15.6 (Varian Medical Systems, Palo Alto, CA) is used for the dose calculations. The system provides two main dose calculation algorithms: (i) the Analytical Anisotropic Algorithm (AAA) is an analytical calculation algorithm based on the pencil beam convolution superposition technique; and (ii) the grid based the Acuros XB (AXB), which solves the LBTE deterministically. AXB agrees the Monte Carlo method within 2% in low density lung, while the AAA shows a difference of 12%[10 ]. In bone and bone-tissue interface regions, dosimetric inaccuracy as large as 6.4% in AAA calculations has been reported, whereas AXB algorithm markedly improved the situation[26 (link)]. In reality, however, AXB is five time slower than AAA for a single field calculation[10 ]. We use low resolution AAA and high resolution AXB as input and output for supervised training of the proposed deep DoseNet (DDN) model and to showcase the capabilities of DDN. The premise of the DDN is to take advantage of the useful features of both algorithms and provide an computationally efficient and dosimetrically accurate technique for treatment planning.
Eclipse treatment planning system v15
Manufactured by Agilent Technologies
Sourced in United States
The Eclipse treatment planning system V15.6 is a software tool developed by Agilent Technologies for radiation therapy treatment planning. It provides functionalities for the creation, optimization, and evaluation of treatment plans for various cancer treatment modalities.
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4 protocols using eclipse treatment planning system v15
1
Dosimetric Accuracy of Eclipse Algorithms
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DIBH-3DCRT Protocol for Breast Cancer
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For the DIBH-3DCRT plan, using a DIBH CT scan performed with the AlignRT® SGRT system (VisionRT, London, UK), treatment plans were produced by radiation therapists in accordance with national guidelines based on an in-house protocol. The plan was optimized for target coverage with a minimum of 95% of the prescribed dose of 40.05 Gy in 15 fractions to the PTV. To achieve dose homogeneity, 6 MV opposing mono-isocentric tangential conformal photon beams with low-energy 6 or 15 MV segments were used.
The treatment plans were calculated with the Acuros XB dose-to-medium algorithm in the Varian Eclipse treatment planning system (v 15.6). The treatment machine used for modelling was a Clinac Linear Accelerator (Varian, Palo Alto, CA, USA).
The treatment plans were calculated with the Acuros XB dose-to-medium algorithm in the Varian Eclipse treatment planning system (v 15.6). The treatment machine used for modelling was a Clinac Linear Accelerator (Varian, Palo Alto, CA, USA).
3
Predictive Models for Radiation Therapy Planning
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Data for training the model consisted of trajectory files and DICOM‐RT plans for 120 unique IMRT fields (877, 098 control points and 105, 251, 760 input samples) and 206 unique VMAT fields (1208, 442 control points and 145, 013, 040 input samples) acquired from four separate linear accelerators between May 2019 and June 2019. Plans were acquired at Duke University Department of Radiation Oncology and prepared in the Eclipse treatment planning system v15.1 (Varian Medical Systems, Palo Alto, CA). Two models of linear accelerators were used to deliver the plans: TrueBeam STx (Varian Medical Systems, Palo Alto, CA) equipped with an HD120 MLC high‐definition multileaf collimator (Varian Medical Systems, Palo Alto, CA) and TrueBeam (Varian Medical Systems, Palo Alto, CA) equipped with Millennium 120 Leaf MLC (Varian Medical Systems, Palo Alto, CA). Our prior work demonstrated that a single combined prediction model can be created for these two models of accelerator.34
4
Precise Prostate IMRT Dose Escalation
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IMRT plans were created in Eclipse™ Treatment Planning System v15.1 (Varian, USA) with a calculation grid size of 1.5 mm. Dose prescription protocols were the following: PTV1 45 Gy in 15 fractions and PTV2 15 Gy in 5 fractions, resulting in 60 Gy for PTV2. A simultaneous integrated boost (SIB) up to 70 Gy for PTV3 for all 20 fractions was prescribed. Adapted from the DELINEATE trial (34 (link)) and based on findings from Martinez et al. (1 (link)), our dose concept aimed for boost doses near 100 Gy (EQD2, a/b=1.6). For PTV2 D98% was ≥ 58.8 Gy and D2% ≤ 70 Gy, for PTV3 D98% was ≥ 68.6 Gy and D2% ≤ 71.4 Gy. Three different plans were created using three different boost volumes for the simultaneous integrated boost (SIB): The SIB volumes were PTV3_1, PTV3_2 and PTV3_3 for plan 1, 2 and 3 respectively. Dose constraints for organs at risk were considered according to CHHiP-, FLAME- and DELINEATE-trial (5 (link), 34 (link)–36 (link)). Dose constraints for Urethra and PRV-Urethra were 62.4 Gy for D2%. Details of RT planning prescription doses and OAR constraints can be found in Supplementary Material 1
To evaluate the impact of urethral sparing three different IMRT plans were calculated: (i) Plan 1 without any dose constraints for urethra, (ii) Plan 2 considered the D2% dose constraint for urethra and (iii) Plan 3 considered the D2% dose constraints for PRV-Urethra.
To evaluate the impact of urethral sparing three different IMRT plans were calculated: (i) Plan 1 without any dose constraints for urethra, (ii) Plan 2 considered the D2% dose constraint for urethra and (iii) Plan 3 considered the D2% dose constraints for PRV-Urethra.
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