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O 7 azabenzotriazol 1 yl n n n n tetramethyluronium hexafluorophosphonate hatu

Manufactured by Iris Biotech
Sourced in Germany

O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphonate (HATU) is a coupling agent used in organic synthesis, particularly in peptide and oligonucleotide synthesis. It facilitates the formation of amide bonds between a carboxylic acid and an amine.

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2 protocols using o 7 azabenzotriazol 1 yl n n n n tetramethyluronium hexafluorophosphonate hatu

1

Peptide Synthesis Using Fmoc Methodology

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All solvents and reagents were used as supplied. Fmoc amino acid derivatives were purchased from Novabiochem (Billerica, MA, USA). O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphonate (HATU), the Rink Amide MBHA resin (0.69 mmol/g), Fmoc-Gly-Wang resin (0.73 mmol/g), and trifluoroacetic acid (TFA) were obtained from IrisBiotech (Marktredwitz, Germany). Solvents for peptide synthesis (N,N-dimethylformamide (DMF), dichloromethane (DCM), and (N-ethyldiisopropylamine (DIEA)) were obtained from Sigma Aldrich (St. Louis, MO, USA).
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2

Solid-Phase Peptide Synthesis Protocol

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All solvents and reagents were used as supplied. Fmoc amino acid derivatives were purchased from Novabiochem. l-Mimosine was obtained from Sigma Aldrich.
O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium hexafluorophosphonate (HATU), the MBHA-Rink amide resin (0.69 mmol/g), Fmoc-Gly-Wang resin (0.73 mmol/g) and trifluoroacetic acid (TFA) were obtained from IrisBiotech. Solvents for peptide synthesis (N,N-dimethylformamide (DMF), dichloromethane (DCM), and (N-ethyldiisopropylamine (DIEA)) were obtained from Sigma Aldrich.
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