Immulite 2000 il 6

Manufactured by Siemens

Sourced in Germany

The IMMULITE® 2000 IL-6 is a diagnostic instrument used for the quantitative determination of interleukin-6 (IL-6) levels in human serum and plasma. It is a fully automated immunoassay system that utilizes a chemiluminescent detection method.

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Lab products found in correlation

E501 module analyser, by Roche (2 mentions) E501 module analyzer, by Roche (1 mentions) Xn 1000 analyzer, by Sysmex (1 mentions) Cobas 6000, by Roche (1 mentions) Evidence investigator, by Randox (1 mentions)

4 protocols using immulite 2000 il 6

Comprehensive Biomarker Analysis in Blood Samples

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A fasting blood test was collected from all included patients from the right antecubital vein. The evaluated parameters and biomarkers included lymphocytes (reference value (RV): cell count × 10⁹/L), hemoglobin (RV: 12–16 g/dL), platelets (RV: 150–400 count × 10⁹/L), lactate dehydrogenase (LDH) level (135–250 U/L), serum creatinine (RV: 0.5–1.1 mg/dL), aspartate aminotransferase (AST) (RV < 32 U/L), (RV < 40 U L); D-dimer (RV < 500 ng/dL), serum ferritin (RV: 15–150 ng/mL), interleukin-6 (RV: <5.9 pg/mL), high-sensitivity C-reactive protein (hs-CRP) (RV 1–5 mg/L), NT-ProBNP (0–125 pg/mL), and high-sensitivity Troponin T (hs-TnT) (RV: <14 pg/mL).
All tests were performed in a certified clinical laboratory (ISO 9001:2015). Inflammatory markers were evaluated using a particle-enhanced immunoturbidimetric, colorimetric (e501 Module Analyzer^®, Roche Diagnostics, Basel, Switzerland) immunoassay system on IMMULITE^® 2000 for interleukin-6 (IMMULITE^® 2000 IL-6, Siemens Healthcare Diagnostic, Marburg, Germany). Cardiac biomarkers were measured by electrochemiluminescence immunoassay with a cobas^® 6000 c 601 analyzer (Roche Diagnostics, Basel, Switzerland). D-dimer results were obtained by a turbidimetric test using an ACL TOP 500^® hemostasis testing system (Werfen Company, Cuenca, Spain).

Aparisi Á., Ybarra-Falcón C., Iglesias-Echeverría C., García-Gómez M., Marcos-Mangas M., Valle-Peñacoba G., Carrasco-Moraleja M., Fernández-de-las-Peñas C., Guerrero Á.L, & García-Azorín D. (2022). Cardio-Pulmonary Dysfunction Evaluation in Patients with Persistent Post-COVID-19 Headache. International Journal of Environmental Research and Public Health, 19(7), 3961.

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Comprehensive Clinical Laboratory Analysis

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We carried out all tests at our certified clinical laboratory (ISO 9001:2015). White blood cells, lymphocyte, and monocyte counts were performed on Sysmex XN-1000® analyzer using the manufacture's reagents (Sysmex Corporation, Japan). Alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), LDL-c, HDL-c, TC, and TG were tested on Roche Cobas 8100 sampling system analyzer (Module Cobas® c 702, Roche Diagnostics, Switzerland) using manufacture's reagents. The methodology for direct LDL-c, HDL-c, and TC methods are based on a standard homogeneous enzymatic colorimetric assay. We tested interleukin 6 (IL6) on IMMULITE® 2000 immunoassay system using the manufacture's luminescent immunoassay reagents (IMMULITE® 2000 IL6, Siemens Healthcare Diagnostic, Germany). Procalcitonin (PCT) measurement in plasma was performed by electrochemiluminescence immunoassay on a chemistry analyzer (Cobas 6000, Roche Diagnostics) limit of detection, as below 0.02 ng/ml. We measured serum C-reactive protein (CRP) by particle enhanced immunoturbidimetric (e501 Module Analyser, Roche Diagnostics). The limit of detection was set below 0.3 mg/L.

Aparisi Á., Iglesias-Echeverría C., Ybarra-Falcón C., Cusácovich I., Uribarri A., García-Gómez M., Ladrón R., Fuertes R., Candela J., Tobar J., Hinojosa W., Dueñas C., González R., Nogales L., Calvo D., Carrasco-Moraleja M., San Román J.A., Amat-Santos I.J, & Andaluz-Ojeda D. (2021). Low-density lipoprotein cholesterol levels are associated with poor clinical outcomes in COVID-19. Nutrition, Metabolism, and Cardiovascular Diseases, 31(9), 2619-2627.

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Correlation of Ella IL-6 with IMMULITE and Evidence Investigator

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Ella^TM IL-6 correlation with IMMULITE^® 2000 IL-6 (Siemens Healthineers, Frimley, UK) and Evidence Investigator™ (Randox, Crumlin, UK). Cytokine and Growth Factors High-Sensitivity Array showed comparable data with R² values of 0.98 and 0.98 respectively.

Mazaheri T., Ranasinghe R., Al-Hasani W., Luxton J., Kearney J., Manning A., Dimitriadis G.K., Mare T, & Vincent R.P. (2022). A cytokine panel and procalcitonin in COVID-19, a comparison between intensive care and non-intensive care patients. PLoS ONE, 17(5), e0266652.

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Biomarker Profiling in Clinical Laboratory

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We carried out all tests at a certified clinical laboratory (ISO 9001:2015). Ferritin and serum high-sensitivity C-reactive protein (hs-CRP) were measured by particle enhanced immunoturbidimetric and colorimetric assay, respectively (e501 Module Analyser^®, Roche Diagnostics, Basel, Switzerland). Interleukin-6 (IL-6) was tested on IMMULITE^® 2000 immunoassay system (IMMULITE^® 2000 IL-6, Siemens Healthcare Diagnostic, Marburg, Germany). Quantification of biomarkers, such as the N-terminal prohormone of brain natriuretic peptide (NT-ProBNP) and the high-sensitivity T troponin (hs TnT) in plasma, were measured by electrochemiluminescence immunoassay with the analyzer Cobas^® 6000 c 601 (Roche Diagnostics, Basel, Switzerland). D-dimer was obtained by a turbidimetric test with the ACL Top 500^® hemostasis testing system (Werfen Company, Cuenca, Spain).

Aparisi Á., Ybarra-Falcón C., García-Gómez M., Tobar J., Iglesias-Echeverría C., Jaurrieta-Largo S., Ladrón R., Uribarri A., Catalá P., Hinojosa W., Marcos-Mangas M., Fernández-Prieto L., Sedano-Gutiérrez R., Cusacovich I., Andaluz-Ojeda D., de Vega-Sánchez B., Recio-Platero A., Sanz-Patiño E., Calvo D., Baladrón C., Carrasco-Moraleja M., Disdier-Vicente C., Amat-Santos I.J, & San Román J.A. (2021). Exercise Ventilatory Inefficiency in Post-COVID-19 Syndrome: Insights from a Prospective Evaluation. Journal of Clinical Medicine, 10(12), 2591.

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