Inveon research workplace image analysis software

Manufactured by Siemens

Sourced in United States

The Inveon Research Workplace Image Analysis software is a tool designed for the analysis of images obtained from Siemens' Inveon research platform. The software provides functionalities for processing and analyzing these images, enabling researchers to extract relevant data and insights from their experimental studies.

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Lab products found in correlation

Inveon, by Siemens (2 mentions) Inveon scanner, by Siemens (1 mentions) Oftagel, by Santen (1 mentions)

Close spelling variants of this product

Inveon (324 citations) Inveon Research Workplace (149 citations) Inveon Research Workplace software (129 citations) Inveon software (29 citations) Inveon Image Research Workplace (3 citations) Inveon Research Workplace analysis software (2 citations)

6 protocols using inveon research workplace image analysis software

PET/CT Image Analysis of Tumor Uptake

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The Inveon Research Workplace Image Analysis software (Siemens Medical Solutions, Knoxville, TN, USA) was used to analyze the PET/CT images. The images were summed from 60 to 80 min post injection, and the tumors were delineated in the images using the CT image as an anatomical reference. Volumes of interest (VOIs) were drawn over whole tumors and then transformed to the PET image. Radioactivity uptake was calculated as the percentage injected dose per gram tissue (%ID/g) in the whole tumor. In addition, the hottest cluster containing voxels with the highest uptake in 10% of the tumor volume (HC 10%) was determined using the same uptake unit (%ID/g).

Silvoniemi A., Silén J., Forsback S., Löyttyniemi E., Schrey A.R., Solin O., Grénman R., Minn H, & Grönroos T.J. (2014). Evaluation of repeated [18F]EF5 PET/CT scans and tumor growth rate in experimental head and neck carcinomas. EJNMMI Research, 4, 65.

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PET/CT Imaging of Small Animals

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If not otherwise stated, chemicals were purchased from commercial sources and used without further purification. PET imaging of mice was performed using a micro-PET/CT scanner (Inveon; Siemens). PET images were reconstructed by performing 2 iterations of a 3-dimensional ordered-subsets expectation maximization algorithm (12 subsets) and then 18 iterations of the accelerated version of 3-dimensional maximum a posteriori, with a matrix size of 128 × 128 × 159. Attenuation correction was applied to a dataset from the CT images. PET images were coregistered with CT and MR images using Inveon Research Workplace image analysis software, version 4.0 (Siemens).

James M.L., Belichenko N.P., Nguyen T.V., Andrews L.E., Ding Z., Liu H., Bodapati D., Arksey N., Shen B., Cheng Z., Wyss-Coray T., Gambhir S.S., Longo F.M, & Chin F.T. (2015). PET Imaging of Translocator Protein (18 kDa) in a Mouse Model of Alzheimer's Disease Using N-(2,5-Dimethoxybenzyl)-2-18F-Fluoro-N-(2-Phenoxyphenyl)Acetamide. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 56(2), 311-316.

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PET-CT Imaging of 18F-FEAU in Mice

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For PET-CT imaging, mice were injected with 150 μCi ¹⁸F-FEAU via the lateral tail vein. Sixty minutes after injection, PET and CT images were collected using a micro-PET-CT hybrid Inveon scanner (Siemens, Munich, Germany). Three-dimensional reconstructions were made using Inveon Research Workplace image analysis software (version 4.0; Siemens).

Skovgard M.S., Hocine H.R., Saini J.K., Moroz M., Bellis R.Y., Banerjee S., Morello A., Ponomarev V., Villena-Vargas J, & Adusumilli P.S. (2021). Imaging CAR T-cell kinetics in solid tumors: Translational implications. Molecular Therapy Oncolytics, 22, 355-367.

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Multimodal PET/CT Imaging of Neuroinflammation in Rats

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Rats were anesthetized with isoflurane/oxygen gas and injected intravenously with [¹⁸F]F-DPA (31.4 ± 2.1 MBq, n = 4 SA at the time of injection = 4.1 ± 0.4 GBq/μmol) for scanning by an Inveon multimodality PET/CT tomograph (Siemens Medical Solutions, Knoxville, TN, USA). In order to prevent eye dryness, a few drops of Oftagel (25 mg/g; Santen, Tampere, Finland) were applied to the eyes of the animals. The scanner has a 12.7 cm axial field of view (FOV) and 10 cm transaxial FOV generating images from 159 transaxial slices. The spatial resolution of the scanner is 1.4 mm according to the manufacturer’s specifications. The animals were scanned for 10 min with computed tomography (CT) for attenuation correction and anatomical reference, and immediately after that, the radiotracer was injected for a 60-min dynamic PET scan. Frames were taken at the following intervals: 30 × 10, 15 × 60, 4 × 300, and 2 × 600 s. Volume of interests (VOIs) were drawn over the whole brain, heart, lung, liver, and kidneys using Inveon Research Workplace Image Analysis software (Siemens Medical Solutions). From the VOIs, time–activity curves (TACs) were obtained and the uptake of [¹⁸F]F-DPA was expressed as percentage of injected dose per milliliter of tissue (%inj. dose/ml).

Keller T., Krzyczmonik A., Forsback S., Picón F.R., Kirjavainen A.K., Takkinen J., Rajander J., Cacheux F., Damont A., Dollé F., Rinne J.O., Haaparanta-Solin M, & Solin O. (2017). Radiosynthesis and Preclinical Evaluation of [18F]F-DPA, A Novel Pyrazolo[1,5a]pyrimidine Acetamide TSPO Radioligand, in Healthy Sprague Dawley Rats. Molecular Imaging and Biology, 19(5), 736-745.

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In Vivo Nerve Imaging Using PET/MRI

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PET and MR images were co-registered using Inveon Research Workplace (IRW) image analysis software (Siemens Healthcare). MR images were used to define the anatomic location of the sciatic nerves and regions of interest (ROIs) were drawn around the injured nerves, proximal to the site of injury, on 5 consecutive transaxial slices covering the neuroma. For uninjured nerves, 2D ROIs were similarly drawn around the corresponding location on 5 slices. Radioactivity counts were then recorded from within the ROIs in the fused PET/MR images. The maximum signals from the ROIs drawn for each nerve were averaged and then normalized to the average signal from adjacent muscle. Since muscle tissue expresses low level S1Rs, it represents non-specific background tracer uptake, which we expect to be very low, and can be used as an internal control to normalize any variability in tracer dose delivery. No attempt was made to compensate for any partial volume effect.

Shen B., Behera D., James M.L., Reyes S.T., Andrews L., Cipriano P.W., Klukinov M., Lutz A.B., Mavlyutov T., Rosenberg J., Ruoho A.E., McCurdy C.R., Gambhir S.S., Yeomans D.C., Biswal S, & Chin F.T. (2017). Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI. Theranostics, 7(11), 2794-2805.

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PET Imaging of Tumor-Associated OX40 in Mice

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PET imaging of mice was performed using the microPET/CT hybrid scanner (Inveon, Siemens). PET images were reconstructed using 2 iterations of 3-dimensional ordered subsets expectation maximization algorithm (12 subsets) and 18 iterations of the accelerated version of 3D-MAP (i.e., FASTMAP) – matrix size of 128 × 128 × 159. CT images were acquired just before each PET scan to enable attenuation correction of the PET data set and provided an anatomic reference for the PET image. Mice were anesthetized using isoflurane gas (2.0%–3.0% for induction and 2.0%–2.5% for maintenance). ⁶⁴Cu-DOTA-OX40 (80-110μCi radiochemical purity of 99% as determined by TLC and SA, specific activity is 185 MBq/mg) was administered intravenously via the tail vein 16 hours after CpG and vehicle intratumoral injections. Static PET scans (10 min) were acquired 16 hours after intravenous administration of ⁶⁴Cu-DOTA-OX40 (40 hours post intra-tumoral injections). Once reconstructed using a three-dimensional ordered subsets expectation maximization (3DOSEM) algorithm, PET images were co-registered with CT images to generate figures using the Inveon Research Workplace (IRW) image analysis software (version 4.0; Siemens).

Sagiv-Barfi I., Czerwinski D.K., Levy S., Alam I.S., Mayer A.T., Gambhir S.S, & Levy R. (2018). Eradication of spontaneous malignancy by local immunotherapy. Science translational medicine, 10(426), eaan4488.

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