Cym51010

Manufactured by Merck Group

CYM51010 is a laboratory instrument designed for the analysis of biological samples. It is a high-precision device used for various scientific and research applications. The core function of CYM51010 is to perform accurate and reliable measurements on a wide range of biological materials.

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Lab products found in correlation

Damgo, by Merck Group (2 mentions) Nicardipine hydrochloride, by Merck Group (1 mentions) Tetrodotoxin citrate, by Alomone (1 mentions) Arm390, by Bio-Techne (1 mentions) Snc80, by Bio-Techne (1 mentions) Fluorogold, by Thermo Fisher Scientific (1 mentions) Naloxone, by Merck Group (1 mentions)

2 protocols using cym51010

Opioid and Related Receptor Ligands

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Carbamoylcholine (carbachol), CTOP, CYM51010, DAMGO, NLT, and nicardipine hydrochloride were obtained from Sigma-Aldrich (St Louis, MO). SNC80 was obtained from Cayman Chemical Company (Ann Arbor, MI), ARM390 from Tocris Bioscience (Bristol, UK), morphine hydrochloride from MacFarlan Smith (Edinburgh, UK), and tetrodotoxin citrate from Alomone (Jerusalem, Israel).

DiCello J.J., Carbone S.E., Saito A., Rajasekhar P., Ceredig R.A., Pham V., Valant C., Christopoulos A., Veldhuis N.A., Canals M., Massotte D, & Poole D.P. (2019). Mu and Delta Opioid Receptors Are Coexpressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon. Cellular and Molecular Gastroenterology and Hepatology, 9(3), 465-483.

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Pharmacological Modulation of Delta Opioid Receptor

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The following chemicals were used in this study: [D-Ala2]-Deltorphin II (Sigma T0675), [D-Ala2, N-Me-Phe4, Gly5-ol]-Enkephalin acetate salt (DAMGO, Sigma E7384), CTOP (Sigma P5296), Naloxone (Sigma N7758), CYM51010 (Sigma SML0980), SNC80 (Tocris Cat. No. 0764), Fluorogold (Thermo Fisher Scientific, H22845), Lucifer Yellow CH (Thermo Fisher Scientific, L453), Cholera Toxin Subunit B (Recombinant) Alexa Fluor 555 Conjugate (Thermo Fisher Scientific, C34776). For inducing DOR internalization, SNC80 (10 mg/kg) was injected subcutaneously to lightly restrained unanesthetized mice using a 30 G needle attached to a microsyringe inserted through the back skin. For behavioral experiments, deltorphin II (1 μg), CTOP (100 ng) or a vehicle solution (0.9% sodium chloride, Hospira NDC 0409-4888-10) were injected intrathecally. A 30 G needle attached to a microsyringe was inserted between the L4/L5 vertebrae, puncturing through the dura (confirmed by the presence of a reflexive tail flick), and then 5 μl of drug was injected.

Wang D., Tawfik V.L., Corder G., Low S.A., François A., Basbaum A.I, & Scherrer G. (2018). Functional Divergence of Delta and Mu Opioid Receptor Organization in CNS Pain Circuits. Neuron, 98(1), 90-108.e5.

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