Microtof esi tof mass spectrometer

Manufactured by Bruker

Sourced in United States

The MicrOTOF ESI-TOF mass spectrometer is a high-performance time-of-flight mass spectrometer designed for accurate mass measurements. It utilizes electrospray ionization (ESI) to introduce samples into the mass analyzer. The MicrOTOF features a time-of-flight (TOF) mass analyzer, which provides high mass accuracy and resolution for the analysis of a wide range of molecular weights.

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Lab products found in correlation

Silica gel 60 f254, by Merck Group (1 mentions) Ac 300 instrument, by Bruker (1 mentions) Avance 3 500 nmr spectrometer, by Bruker (1 mentions) Zetasizer nano z, by Malvern Panalytical (1 mentions) Q50 thermogravimetric analyzer, by TA Instruments (1 mentions) Fluorescence microscope, by Nikon (1 mentions) Attune nxt flow cytometer, by Thermo Fisher Scientific (1 mentions) 1200 series hplc system, by Agilent Technologies (1 mentions) Alpha ftir spectrometer, by Bruker (1 mentions)

Spelling variants of this product

MicrOTOF mass spectrometer (74 citations) Bruker spectrometers (71 citations) MicrOTOF spectrometer (54 citations) MicrOTOF-Q II™ ESI-Qq-TOF mass spectrometer (12 citations) MicroTOF ESI (10 citations) MicroTOF ESI spectrometer (5 citations) MicrOTOF focus (ESI-TOF) mass spectrometer (3 citations) ESI-TOF mass spectrometer micrOTOF II focus (2 citations) Daltonics micrOTOF focus (ESI-TOF) mass spectrometer (2 citations) MicrOTOF-Q electrospray ionization quadrupole time-of-flight (ESI-Q-TOF) mass spectrometer (2 citations)

4 protocols using microtof esi tof mass spectrometer

Synthesis and Characterization of Novel Compounds

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Solvents, unless otherwise specified, were of analytical reagent grade or of the highest quality commercially available. Synthetic starting materials, reagents and solvents were purchased from InterBioscreen (Chernogolovka, Russia, https://www.ibscreen.com/) and mycophenolic acid (CAS number 24280-93-1) was from Sigma-Aldrich Chemie (Steinheimm, Germany). Melting points (°C) were determined with a Boetius apparatus and are reported without correction. ¹H-NMR spectra of the novel synthesized compounds in DMSO-d₆ solutions were recorded on an AC 300 instrument (Bruker, (Bruker, Karlsruhe, Germany) at 298 K. ¹³C-NMR in d-CHCl₃ were recorded on Bruker AC 500 instrument. Chemical shift (δ) values for ¹H-NMR spectra are reported in parts per million (ppm) with the solvent resonance as the internal standard. MS spectra were recorded on an ESI-MS instrument (Micromass ZMD Waters, Milford, MA, USA). TLC analyses were performed with Merck silica gel 60 F254 precoated plates, and each of the synthesized compounds showed a single spot. High-resolution mass spectra (HRMS) were registered on Bruker MicrOTOF ESI-TOF mass spectrometer (see Supplementary Material).

Tsolaki E., Eleftheriou P., Kartsev V., Geronikaki A, & Saxena A.K. (2018). Application of Docking Analysis in the Prediction and Biological Evaluation of the Lipoxygenase Inhibitory Action of Thiazolyl Derivatives of Mycophenolic Acid. Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry, 23(7), 1621.

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Detailed Characterization of Synthesized Compounds

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All chemical reagents and solvents were of reagent grade or purified according to standard methods before use. The ¹H NMR and ¹³C NMR spectra were recorded using JNM-ECS-400 MHz and 100 MHz. Mass spectrometry was performed using a Bruker Micro TOF ESI-TOF mass spectrometer. During the experiment, all pH values were measured by PH-10C pH meter. The purity of the synthesized derivatives was characterized by a purity test (as shown in Figures S1–S42).

Ma Y., Tian Y., Zhou Z., Chen S., Du K., Zhang H., Jiang X., Lu J., Niu Y., Tu L., Wang J., Liu H., Zhu H., Chen P, & Liu Y. (2022). Design, Synthesis and Biological Evaluation of Neocryptolepine Derivatives as Potential Anti-Gastric Cancer Agents. International Journal of Molecular Sciences, 23(19), 11924.

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Extensive Characterization of Synthesized Compounds

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Materials and reagents were purchased from commercial sources without further purification. ¹H NMR, ¹³C NMR, ¹⁹F NMR, and ³¹P NMR spectrum were acquired from either a Bruker AdvanceIII 400 NMR spectrometer or a Bruker AvanceIII 500 NMR spectrometer. Mass spectrometry was conducted on a Bruker MicrOTOF ESI-TOF mass spectrometer. Gel permeation chromatography (GPC) was conducted on an Agilent 1260 LC using tetrahydrofuran as the eluent. Molecular weights are versus polystyrene standards. The GPC using trifluoroethanol as the eluent was conducted on an Agilent 1200 series HPLC system, using polymethylmethacrylate standards for molecular weight calculation. Dynamic light scattering and zeta potential measurement were carried out on a Malvern Zetasizer Nano ZS. Confocal microscopy images were obtained from a Nikon fluorescence microscope either equipped with a Yokogawa spinning disk or a spectral detector unit. Flow cytometry experiments were conducted on a ThermoFisher Attune NxT flow cytometer. The infrared spectra were collected on a Bruker Alpha FT-IR Spectrometer with a spectral range from 3500 cm⁻¹ to 400 cm⁻¹. Thermogravimetric analysis was performed under N₂ flow from room temperature to 600 °C using a TA Instrument Q50 thermogravimetric analyzer.

Jiang Z., He H., Liu H, & Thayumanavan S. (2019). Cellular Uptake Evaluation of Amphiphilic Polymer Assemblies: Importance of Interplay between Pharmacological and Genetic Approaches. Biomacromolecules, 20(12), 4407-4418.

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Synthesis and Characterization of MMNC

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All synthetic materials were purchased from the reagent manufacturer, and no purification operations were carried out. All organic reagents were of analytical reagent grade. ¹H NMR and ¹³C NMR spectra were recorded using a JNM-ECS-400 at 400 MHz. Mass spectrometry analysis was performed using a Bruker Micro TOF ESI-TOF mass spectrometer (Bruker Company, Billerica, MA, USA). All pH measurements during the experiment were performed using a PH-10C pH meter. MMNC was prepared as reported in our previous study [12 (link)].

Ma Y., Zhu H., Jiang X., Zhou Z., Zhou Y., Tian Y., Zhang H., Sun M., Tu L., Lu J., Niu Y., Liu H., Liu Y, & Chen P. (2023). Biological Evaluation of 8-Methoxy-2,5-dimethyl-5H-indolo[2,3-b] Quinoline as a Potential Antitumor Agent via PI3K/AKT/mTOR Signaling. International Journal of Molecular Sciences, 24(20), 15142.

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