Magnetom verio 3.0t scanner

The brain structure image was acquired by using a Siemens Magnetom Verio 3.0 T scanner (Siemens, Munich, Germany). The parameters of T1-weighted 3D magnetization prepared rapid gradient echo (MPRAGE) sequences were as follows: TE = 2.98 ms, TR = 2,300 ms; matrix size = 240 × 256; flip angle of 9 degree, field of view (FOV) = 240 × 256 mm; slice thickness = 1.2 mm. Volumetric data was assessed by automated procedures, which have been described by Wolz et al. (17 (link)). For each subject, volume and asymmetry with hippocampus, corpus callosum (CC), as well as the brain size index were extracted (by using FreeSurfer). Moreover, to assess the role of differences in left and right, an asymmetry index was computed using the equation: [right volume-left volume]/[total volume] × 100%. Quality control was carefully conducted by overlapping the output parcellations on FreeSurfer's template and visual assessment was performed to ensure the registration and parcellation quality.

In this study, the microwave probe (ECO-100AI13, 1.8 mm, 15 cm, Co., Ltd. Nanjing, China) and MR-compatible MWA apparatus (2450 MHz, ECO Medical Instrument Co., Ltd. Nanjing, China) were placed at a distance of 2.5-3 meters beside the MR-compatible operating table. ECG gating sensors and respiratory were placed around the finger and chest wall, respectively. After using the cod liver oil capsule matrix to mark the surface of the body, a standard MR protocol was completed to locate intrahepatic lesions. The procedure was guided by a 3.0 T dual gradient MRI (Magnetom Verio 3.0 T scanner, Siemens Healthineers, Germany) with a 70 cm inner-diameter closed bore. The MR scan sequence and parameters used in our study are shown in (Table 2):

Regarding ADNI data, T1-weighted structural imaging was collected using a 3D MPRAGE (magnetization prepared rapid gradient-echo imaging) sequence with slightly different MR parameters among participants. The MR images acquired using Siemens scanner were scanned with the parameters as follows: repetition time (TR) = 2,300 ms, matrix = 240 × 256 × 176, slice thickness = 1.2 mm, and those parameters in General Electric scanner were as follows: TR = 7 ms, matrix = 256 × 256 × 166, slice thickness = 1.2 mm and those parameters in Philips scanner were as follows: TR = 6.8 ms, matrix = 256 × 256 × 170, slice thickness = 1.2 mm, respectively. More detailed information about the image acquisition procedures is available on the ADNI website². Additionally, the MR data of Shanghai Mental Health Center were acquired using a Siemens Magnetom Verio 3.0 T scanner, and high-resolution T1-weighted structural images with 176 sagittal slices were collected using a MPRAGE sequence (TR = 2,530 ms, TE = 3.5 ms, flip angle = 9°, FOV = 256 mm × 256 mm, voxel size = 1.0 × 1.0 × 1.2 mm³).

MRI was performed on a Siemens MAGNETOM Verio 3.0 T scanner (Siemens Healthcare), using a 32-channel head coil. Each patient had conventional structural imaging, acquired with the following parameters: T₁ MPRAGE [echo time (TE) = 2.98 ms, repetition time (TR) = 2.3 s, 1 mm isotropic voxel, 256 × 256 mm field of view, inversion time (TI) = 900 ms, flip angle = 9°, GRAPPA = 2, 5 min scanning time], T₂ FLAIR (TE = 395 ms, TR = 5 s, TI = 1800 ms, 1 mm isotropic voxel, 250 × 250 mm field of view, GRAPPA = 2, 6 min scanning time), susceptibility weighted imaging (SWI) (120 1.2-mm-thick transverse slices, TR = 28 ms, TE = 20 ms, flip angle = 15°, in-plane resolution = 0.8 × 0.6 mm, field of view = 225 × 225 mm). Brain tissue volumes, white matter, grey matter and total intracranial volume (TICV) were computed for all participants, using a standard morphometry pipeline on T₁-weighted images with SPM12, University College London, www.fil.ion.ucl.ac.uk/spm (1 October 2021, date last accessed).⁴⁷ These procedures were previously described in more detail.^{7 (link)} Analysis of behavioural tests and MRI volume estimates were conducted using the R statistical environment.⁴⁸

MRI data were acquired using a MAGNETOM Verio 3.0-T scanner (Siemens Healthineers, Erlangen, Germany) with a 32-channel phased array head coil.
Light and sound shielding were applied before and during the scanning. Subjects were required to close their eyes and keep calm throughout the examination. Their heads were immobilized with foam pads, and their ears were plugged with earplugs. The rs-fMRI data were obtained using a single-pass gradient recalled echoplanar imaging (EPI) sequence with the following parameters: interleaved scanning order, repetition time (TR) = 3,000 ms, slice number = 43, matrix size = 64 × 64, transverse orientation, slice thickness = 3.0 mm, flip angle = 90°, gap = 0 (voxel size = 3.6 × 3.6 × 3.0 mm³), field of view (FOV) = 230 × 230 mm², and number of acquisitions = 200.

All the subjects had completed T1 structural magnetic resonance scans at baseline. The images were acquired by using a Siemens Magnetom Verio 3.0T scanner (Siemens, Munich, Germany), and the parameters were as follows: TE = 2.98 ms, TR = 2,300 ms, slice thickness, 1.2 mm, flip angle, 9°, matrix size, 240 × 256, field of view (FOV), 240 × 256 mm, and the number of slices, 176 (14 (link)). All the sMRI data were processed using Clinica in FreeSurfer v6.0, including spatial registration, cortical thickness estimation, extraction of cortical surface segmentation of the subcortical structures, and parcellation into 46 global structures (12 (link)). Based on previous studies, we used the hippocampus, amygdala, and globus pallidus as our core research brain area (18 (link)).